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Pfdn2 Gene Detail
Summary
  • Symbol
    Pfdn2
  • Name
    prefoldin 2
  • Synonyms
    ESTM27, W48336
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276111
    NCBI Gene: 18637
  • Gene Overview
    MyGene.info: PFDN2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171173238-171186822 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276111
protein coding gene Chr1:171172522-171186822 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016757
protein coding gene Chr1:177139995-177155304 (+)
A/J MGP_AJ_G0016737
protein coding gene Chr1:169921923-169935591 (+)
AKR/J MGP_AKRJ_G0016703
protein coding gene Chr1:175016951-175030664 (+)
BALB/cJ MGP_BALBcJ_G0016698
protein coding gene Chr1:170414376-170429921 (+)
C3H/HeJ MGP_C3HHeJ_G0016521
protein coding gene Chr1:175259258-175274909 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017159
protein coding gene Chr1:183031275-183044772 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014867
protein coding gene Chr1:161608795-161621609 (+)
CAST/EiJ MGP_CASTEiJ_G0016102
protein coding gene Chr1:174892536-174906170 (+)
CBA/J MGP_CBAJ_G0016496
protein coding gene Chr1:189538975-189555142 (+)
DBA/2J MGP_DBA2J_G0016603
protein coding gene Chr1:168763938-168778095 (+)
FVB/NJ MGP_FVBNJ_G0016599
protein coding gene Chr1:167113205-167126974 (+)
LP/J MGP_LPJ_G0016674
protein coding gene Chr1:178253668-178268609 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016626
protein coding gene Chr1:196818347-196832951 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017196
protein coding gene Chr1:174884508-174899478 (+)
PWK/PhJ MGP_PWKPhJ_G0015888
protein coding gene Chr1:167986288-168001075 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015672
protein coding gene Chr1:173669934-173685642 (+)
WSB/EiJ MGP_WSBEiJ_G0016164
protein coding gene Chr1:175002366-175016509 (+)



Homology
more
  • Human Ortholog
    PFDN2, prefoldin subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PFDN2, prefoldin subunit 2
  • Synonyms
    PFD2
  • Links
    NCBI Gene ID: 5202
    neXtProt AC: NX_Q9UHV9
    UniProt: Q9UHV9

  • Chr Location
    1q23.3; chr1:161100556-161118076 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    43
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    37
  • Targeted
    2
  • Transgenic
    1
  • Genomic Mutations
    2 involving Pfdn2
  • Incidental Mutations
  • Find Mice (IMSR)
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006412 Ensembl Gene Model | MGI Sequence Detail 13585 C57BL/6J ±  kb
transcript ENSMUST00000135941 Ensembl | MGI Sequence Detail 1735 Not Applicable  
polypeptide ENSMUSP00000120106 Ensembl | MGI Sequence Detail 154 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    Genomic 2
    cDNA 5
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1334437
References
more
  • Summaries
    All 29
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:48636 Vainberg IE, et al., Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell. 1998 May 29;93(5):863-73
  • Latest
    J:248921 Chintalapudi SR, et al., Multipronged approach to identify and validate a novel upstream regulator of Sncg in mouse retinal ganglion cells. FEBS J. 2016 Feb;283(4):678-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory