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Cldn2 Gene Detail
Summary
  • Symbol
    Cldn2
  • Name
    claudin 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276110
    NCBI Gene: 12738
  • Gene Overview
    MyGene.info: CLDN2
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:139800828-139811386 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 61.35 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276110
protein coding gene ChrX:139800808-139811386 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036128
protein coding gene ChrX:137314149-137324784 (+)
A/J MGP_AJ_G0036106
protein coding gene ChrX:136692256-136709253 (+)
AKR/J MGP_AKRJ_G0036031
protein coding gene ChrX:141088688-141099266 (+)
BALB/cJ MGP_BALBcJ_G0036096
protein coding gene ChrX:135041740-135052322 (+)
C3H/HeJ MGP_C3HHeJ_G0035805
protein coding gene ChrX:137348558-137359121 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036621
protein coding gene ChrX:141351626-141362182 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033445
protein coding gene ChrX:128449698-128460443 (+)
CAST/EiJ MGP_CASTEiJ_G0035096
protein coding gene ChrX:118148724-118159314 (+)
CBA/J MGP_CBAJ_G0035782
protein coding gene ChrX:145682535-145693092 (+)
DBA/2J MGP_DBA2J_G0035939
protein coding gene ChrX:135869103-135879658 (+)
FVB/NJ MGP_FVBNJ_G0035873
protein coding gene ChrX:135102041-135112619 (+)
LP/J MGP_LPJ_G0036030
protein coding gene ChrX:138286686-138297268 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035910
protein coding gene ChrX:153199393-153209957 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036657
protein coding gene ChrX:136625816-136636372 (+)
PWK/PhJ MGP_PWKPhJ_G0034789
protein coding gene ChrX:115072508-115083209 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034615
protein coding gene ChrX:118683562-118694201 (+)
WSB/EiJ MGP_WSBEiJ_G0035231
protein coding gene ChrX:134952469-134963028 (+)



Homology
more
  • Human Ortholog
    CLDN2, claudin 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CLDN2, claudin 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9075
    neXtProt AC: NX_P57739
    UniProt: P57739

  • Chr Location
    Xq22.3; chrX:106900164-106930861 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous females show altered Na+ and water reabsorption in the kidney proximal tubules. Males hemizygous for a null allele show increased transcellular Na+ reabsorption in the thick ascending limb, higher renal oxygen consumption, medullary hypoxia, and susceptibility to ischemic renal injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047230 Ensembl Gene Model | MGI Sequence Detail 10559 C57BL/6J ±  kb
    transcript ENSMUST00000054889 Ensembl | MGI Sequence Detail 3044 Not Applicable  
    polypeptide ENSMUSP00000054219 Ensembl | MGI Sequence Detail 230 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 84
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147942
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 16
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:48635 Furuse M, et al., Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol. 1998 Jun 29;141(7):1539-50
    • Latest
      J:261068 Szabo R, et al., Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy. PLoS One. 2018;13(4):e0194660

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory