Mmp16
Gene Detail

Symbol Name ID

Mmp16 matrix metallopeptidase 16 MGI:1276107

Synonyms

Membrane type 3-MMP, MT3-MMP

Feature Type

protein coding gene

Genetic Map

Chromosome 4

7.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr4:17852893-18119145 bp, + strand From VEGA annotation of GRCm38   266253 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Mmp16 ± 2 cM)

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp16

Human ortholog

MMP16 matrix metallopeptidase 16 (membrane-inserted) NCBI Gene ID 4325
Human Synonyms: C8orf57, MMP-X2, MT3-MMP, MT-MMP2, MT-MMP3
Human Chr8:89049460-89339717 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a gene disruption display normal morphology, clinical chemistry, hematology, and behavior. Mice homozygous for a null allele exhibit reduced skeletal growth.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	collagen catabolic process, proteolysis
Component	extracellular matrix, integral to membrane, ...
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (189)    Tissues (83)    Images (71)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	91
In situ reporter (knock in)	60
RT-PCR	38

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(23) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000004650 (Evidence)
Ensembl Gene Model	ENSMUSG00000028226 (Evidence)
Entrez Gene	17389 (Evidence)
UniGene	187315
DFCI	TC1583859, TC1597572, TC1713499
DoTS	DT.101735731, DT.91326799, DT.91330992, DT.94134380
NIA Mouse Gene Index	U042506
EC	3.4.24.-
Consensus CDS Project	CCDS17989.1
International Mouse Knockout Project Status	Mmp16

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004650	VEGA Gene Model | MGI Sequence Detail	266253	C57BL/6J
transcript	OTTMUST00000010497	VEGA | MGI Sequence Detail	5011	Not Applicable
polypeptide	OTTMUSP00000004975	VEGA | MGI Sequence Detail	607	Not Applicable

All sequences(46) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(986 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000585	Hemopexin/matrixin
InterPro	IPR018486	Hemopexin/matrixin, conserved site
InterPro	IPR018487	Hemopexin/matrixin, repeat
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021158	Peptidase M10A, cysteine switch, zinc binding site
InterPro	IPR021190	Peptidase M10A, matrix metallopeptidase
InterPro	IPR021805	Peptidase M10A, matrix metallopeptidase, C-terminal
InterPro	IPR016293	Peptidase M10A, matrix metallopeptidase, stromelysin type
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010476	matrix metalloproteinase-16

References

(Earliest) J:48335 Seldin MF, et al., Mapping of two mouse membrane-type matrix metalloproteinase (MT-MMP) genes, Mmp15 and Mmp16, to mouse chromosomes 8 and 4, respectively. Genomics. 1998 Jun 1;50(2):295-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)