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Mmp16
Gene Detail
 Symbol
Name
ID
Mmp16
matrix metallopeptidase 16
MGI:1276107
Synonyms Membrane type 3-MMP, MT3-MMP
Feature Type protein coding gene
Genetic Map
Chromosome 4
7.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:17852893-18119145 bp, + strand
From VEGA annotation of GRCm38

  266253 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55939  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp16

Human
homologs
Human Homolog MMP16, matrix metallopeptidase 16 (membrane-inserted)
NCBI Gene ID 4325
neXtProt AC  NX_P51512
Human Synonyms  C8orf57, MMP-X2, MT3-MMP, MT-MMP2, MT-MMP3
Human Chr (Location)  8q21.3; chr8:88037232-88327488 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene disruption display normal morphology, clinical chemistry, hematology, and behavior. Mice homozygous for a null allele exhibit reduced skeletal growth.
 
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process bone development, chondrocyte proliferation, ...
Component extracellular matrix, integral component of membrane, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (189)    Tissues (83)    Images (71)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 91
In situ reporter (knock in) 60
RT-PCR 38
cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(24) cDNA(23) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000004650 (Evidence)
Ensembl Gene ModelENSMUSG00000028226 (Evidence)
Entrez Gene17389 (Evidence)
UniGene187315
DFCITC1583859, TC1597572, TC1713499
DoTSDT.101735731, DT.91326799, DT.91330992, DT.94134380
NIA Mouse Gene IndexU042506
EC3.4.24.-
Consensus CDS ProjectCCDS17989.1
International Mouse Knockout Project StatusMmp16
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004650 VEGA Gene Model | MGI Sequence Detail 266253 C57BL/6J ±  kb
transcript OTTMUST00000010497 VEGA | MGI Sequence Detail 5011 Not Applicable 
polypeptide OTTMUSP00000004975 VEGA | MGI Sequence Detail 607 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(4) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(1183 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminal
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010476 matrix metalloproteinase-16
References (Earliest) J:48335 Seldin MF, et al., Mapping of two mouse membrane-type matrix metalloproteinase (MT-MMP) genes, Mmp15 and Mmp16, to mouse chromosomes 8 and 4, respectively. Genomics. 1998 Jun 1;50(2):295-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory