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Alox12e Gene Detail
Summary
  • Symbol
    Alox12e
  • Name
    arachidonate lipoxygenase, epidermal
  • Synonyms
    8-LOX, Alox12-ps1, Alox12-ps2, Aloxe, e-LOX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1274790
    NCBI Gene: 11685
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70206436-70213454 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.99 cM, cytoband B1-B3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1274790
protein coding gene Chr11:70206436-70213545 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018591
protein coding gene Chr11:70844755-70851781 (-)
A/J MGP_AJ_G0018559
protein coding gene Chr11:68147202-68154220 (-)
AKR/J MGP_AKRJ_G0018528
protein coding gene Chr11:70182512-70189534 (-)
BALB/cJ MGP_BALBcJ_G0018531
protein coding gene Chr11:68470351-68477377 (-)
C3H/HeJ MGP_C3HHeJ_G0018344
protein coding gene Chr11:70218662-70225688 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018982
protein coding gene Chr11:72935956-72942974 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016627
protein coding gene Chr11:65080343-65087252 (-)
CAST/EiJ MGP_CASTEiJ_G0017899
protein coding gene Chr11:70469722-70476740 (-)
CBA/J MGP_CBAJ_G0018316
protein coding gene Chr11:76255120-76262146 (-)
DBA/2J MGP_DBA2J_G0018426
protein coding gene Chr11:67726098-67733118 (-)
FVB/NJ MGP_FVBNJ_G0018416
protein coding gene Chr11:67378454-67385476 (-)
LP/J MGP_LPJ_G0018496
protein coding gene Chr11:71413099-71420125 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018439
protein coding gene Chr11:76823174-76830200 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019024
protein coding gene Chr11:70454559-70461585 (-)
PWK/PhJ MGP_PWKPhJ_G0017673
protein coding gene Chr11:68378596-68385603 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017463
protein coding gene Chr11:70258132-70265134 (-)
WSB/EiJ MGP_WSBEiJ_G0017953
protein coding gene Chr11:70117204-70124233 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000018907 Ensembl Gene Model | MGI Sequence Detail 7019 C57BL/6J ±  kb
transcript ENSMUST00000019051 Ensembl | MGI Sequence Detail 2422 Not Applicable  
polypeptide ENSMUSP00000019051 Ensembl | MGI Sequence Detail 662 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    Genomic 3
    cDNA 38
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-1283, MGD-MRK-19370, MGD-MRK-19406, MGI:102526, MGI:2144520
References
more
  • Summaries
    All 51
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:289748 Han YH, et al., A maresin 1/RORalpha/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis. J Clin Invest. 2019 Mar 11;129(4):1684-1698

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/15/2022
MGI 6.22
The Jackson Laboratory