Taldo1
Gene Detail

Symbol Name ID

Taldo1 transaldolase 1 MGI:1274789

Feature Type

protein coding gene

Genetic Map

Chromosome 7

86.73 cM, cytoband F3-F4
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:141392199-141402968 bp, + strand From VEGA annotation of GRCm38   10770 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4916  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transaldolase
Gene Tree: Taldo1

Human homologs

Human Homolog		TALDO1, transaldolase 1
NCBI Gene ID		6888
neXtProt AC		NX_P37837
Human Synonyms		TAL, TALDOR, TALH, TAL-H
Human Chr (Location)		11p15.5-p15.4; chr11:747432-765024 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TALDO1

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(4)
 

Homozygous mutation of this gene results in male infertility due to defective sperm motility because of functional and structural defects of mitochondria in the sperm. Heterozygous mice show reduced male fertility.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	carbohydrate metabolic process, fructose 6-phosphate metabolic process, ...
Component	cytoplasm, cytosol, ...
Function	carbohydrate binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (14)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(399)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(399) cDNA(399)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000027257 (Evidence)
Ensembl Gene Model	ENSMUSG00000025503 (Evidence)
Entrez Gene	21351 (Evidence)
UniGene	29182
DFCI	TC1573334
DoTS	DT.537679, DT.94377099, DT.97415341
NIA Mouse Gene Index	U008958, U125281
EC	2.2.1.2
PDB	2CWN, 2E1D
Consensus CDS Project	CCDS22011.1
International Mouse Knockout Project Status	Taldo1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027257	VEGA Gene Model | MGI Sequence Detail	10770	C57BL/6J
transcript	OTTMUST00000067396	VEGA | MGI Sequence Detail	1229	Not Applicable
polypeptide	OTTMUSP00000033905	VEGA | MGI Sequence Detail	337	Not Applicable

All sequences(32) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(127 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013785	Aldolase-type TIM barrel
InterPro	IPR001585	Transaldolase
InterPro	IPR018225	Transaldolase, active site
InterPro	IPR004730	Transaldolase type 1
Protein Ontology	PR:000016045	transaldolase

References

(Earliest) J:47229 Kusuda J, et al., Cloning and chromosomal localization of a paralog and a mouse homolog of the human transaldolase gene. Gene. 1998 Mar 16;209(1-2):13-21
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)