Trdmt1
Gene Detail

Symbol Name ID

Trdmt1 tRNA aspartic acid methyltransferase 1 MGI:1274787

Synonyms

Dnmt2, Rnmt2

Feature Type

protein coding gene

Genetic Map

Chromosome 2

10.00 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:13509014-13544664 bp, - strand From VEGA annotation of GRCm38   35651 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Trdmt1 ± 2 cM)

Gene Tree: Trdmt1

Human ortholog

TRDMT1 tRNA aspartic acid methyltransferase 1 NCBI Gene ID 1787
Human Synonyms: DMNT2, DNMT2, MHSAIIP, PUMET, RNMT1
Human Chr10:17184982-17244070 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(7) : Targeted(4) Gene trapped(3)
 

Mice homozygous for disruptions in this gene have a decreased proportion of natural killer cells in the peripheral blood.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	DNA methylation, methylation, ...
Component	nucleus
Function	DNA binding, methyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (116)    Tissues (114)   
Theiler Stages: 2, 3, 4, 5, 13, 17, 22, 28

Assay Type	Results
RNA in situ	94
Northern blot	3
RT-PCR	10
RNase protection	9

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(1) cDNA(17) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000011229 (Evidence)
Ensembl Gene Model	ENSMUSG00000026723 (Evidence)
Entrez Gene	13434 (Evidence)
UniGene	6979
DFCI	TC1584193
DoTS	DT.60104801
NIA Mouse Gene Index	U022299
EC	2.1.1.204
Consensus CDS Project	CCDS15695.1
International Mouse Knockout Project Status	Trdmt1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011229	VEGA Gene Model | MGI Sequence Detail	35651	C57BL/6J
transcript	OTTMUST00000026356	VEGA | MGI Sequence Detail	3784	Not Applicable
polypeptide	OTTMUSP00000012054	VEGA | MGI Sequence Detail	415	Not Applicable

All sequences(26) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(82 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001525	C-5 cytosine methyltransferase
InterPro	IPR018117	DNA methylase, C-5 cytosine-specific, active site
InterPro	IPR025813	tRNA (cytosine(38)-C(5))-methyltransferase TRDMT1
Protein Ontology	PR:000016622	tRNA (cytosine-5-)-methyltransferase

References

(Earliest) J:48082 Okano M, et al., Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. Nucleic Acids Res. 1998 Jun 1;26(11):2536-40
(Latest) J:172805 Wang Q, et al., Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs. BMC Genomics. 2011;12:204
All references(37)