About   Help   FAQ
Trdmt1 Gene Detail
Summary
  • Symbol
    Trdmt1
  • Name
    tRNA aspartic acid methyltransferase 1
  • Synonyms
    Dnmt2, Rnmt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1274787
    NCBI Gene: 13434
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:13513825-13549479 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 10.00 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1274787
protein coding gene Chr2:13509690-13549479 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025356
protein coding gene Chr2:11010318-11045992 (-)
A/J MGP_AJ_G0025333
protein coding gene Chr2:10595727-10631568 (-)
AKR/J MGP_AKRJ_G0025302
protein coding gene Chr2:10906095-10942080 (-)
BALB/cJ MGP_BALBcJ_G0025329
protein coding gene Chr2:10588508-10624208 (-)
C3H/HeJ MGP_C3HHeJ_G0025089
protein coding gene Chr2:10849409-10887065 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025771
protein coding gene Chr2:11308657-11351785 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023186
protein coding gene Chr2:10208214-10244141 (-)
CAST/EiJ MGP_CASTEiJ_G0024552
protein coding gene Chr2:10813141-10856880 (-)
CBA/J MGP_CBAJ_G0025068
protein coding gene Chr2:11779834-11826391 (-)
DBA/2J MGP_DBA2J_G0025200
protein coding gene Chr2:10490197-10525972 (-)
FVB/NJ MGP_FVBNJ_G0025162
protein coding gene Chr2:10388942-10425719 (-)
LP/J MGP_LPJ_G0025286
protein coding gene Chr2:10917709-10955893 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025194
protein coding gene Chr2:11658842-11710101 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025829
protein coding gene Chr2:10819292-10855701 (-)
PWK/PhJ MGP_PWKPhJ_G0024303
protein coding gene Chr2:10376465-10415174 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024103
protein coding gene Chr2:10849374-10890548 (-)
WSB/EiJ MGP_WSBEiJ_G0024622
protein coding gene Chr2:10914244-10949928 (-)



Homology
more
  • Human Ortholog
    TRDMT1, tRNA aspartic acid methyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRDMT1, tRNA aspartic acid methyltransferase 1
  • Synonyms
    DMNT2, DNMT2, MHSAIIP, PUMET, RNMT1
  • Links
    NCBI Gene ID: 1787
    neXtProt AC: NX_O14717
    UniProt: O14717

  • Chr Location
    10p13; chr10:17137336-17202054 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a decreased proportion of natural killer cells in the peripheral blood.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026723 Ensembl Gene Model | MGI Sequence Detail 35655 C57BL/6J ±  kb
    transcript ENSMUST00000124488 Ensembl | MGI Sequence Detail 3788 Not Applicable  
    polypeptide ENSMUSP00000114572 Ensembl | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 18
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:48082 Okano M, et al., Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. Nucleic Acids Res. 1998 Jun 1;26(11):2536-40
    • Latest
      J:340781 Satir-Basaran G, et al., Mouse Paternal RNAs Initiate a Pattern of Metabolic Disorders in a Line-Dependent Manner. Front Genet. 2022;13:839841

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory