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Trdmt1
Gene Detail
Symbol

Name
ID
Trdmt1
tRNA aspartic acid methyltransferase 1
MGI:1274787
Synonyms
Dnmt2, Rnmt2
Feature Type
protein coding gene
Genetic Map
Chromosome 2
10.00 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:13509014-13544664 bp, - strand
From VEGA annotation of GRCm38

  35651 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Trdmt1

Human
homologs
Human Homolog TRDMT1, tRNA aspartic acid methyltransferase 1
NCBI Gene ID 1787
neXtProt AC  NX_O14717
Human Synonyms  DMNT2, DNMT2, MHSAIIP, PUMET, RNMT1
Human Chr (Location)  10p15.1; chr10:17137829-17202090 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have a decreased proportion of natural killer cells in the peripheral blood.
 
Interactions
Trdmt1 interacts with 297 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process DNA methylation, methylation, ...
Component cytoplasm, nucleus
Function DNA binding, methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (111)    Tissues (109)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 3
RT-PCR 5
RNase protection 9
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(17) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000011229 (Evidence)
Ensembl Gene ModelENSMUSG00000026723 (Evidence)
Entrez Gene13434 (Evidence)
UniGene6979
DFCITC1584193
DoTSDT.60104801
NIA Mouse Gene IndexU022299
EC2.1.1.204
Consensus CDS ProjectCCDS15695.1
International Mouse Knockout Project StatusTrdmt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011229 VEGA Gene Model | MGI Sequence Detail 35651 C57BL/6J ±  kb
transcript OTTMUST00000026356 VEGA | MGI Sequence Detail 3784 Not Applicable 
polypeptide OTTMUSP00000012054 VEGA | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(9) UniProt(7)
Polymorphisms
SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001525 C-5 cytosine methyltransferase
InterPro IPR025813 DNA and tRNA (cytosine-5)-methyltransferase family
InterPro IPR018117 DNA methylase, C-5 cytosine-specific, active site
Protein Ontology PR:000016622 tRNA (cytosine-5-)-methyltransferase
References
(Earliest) J:48082 Okano M, et al., Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. Nucleic Acids Res. 1998 Jun 1;26(11):2536-40
(Latest) J:203322 Hussain S, et al., The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. Mol Cell Biol. 2013 Apr;33(8):1561-70
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory