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Gpr98
Gene Detail
 Symbol
Name
ID
Gpr98
G protein-coupled receptor 98
MGI:1274784
Synonyms Mass1, Mgr1, Neurepin, VLGR1
Feature Type protein coding gene
Genetic Map
Chromosome 13
42.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:81095068-81633154 bp, - strand
From VEGA annotation of GRCm38

  538087 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19815  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gpr98

Human
homologs
Human Homolog GPR98, G protein-coupled receptor 98
NCBI Gene ID 84059
neXtProt AC  NX_Q8WXG9
Human Synonyms  FEB4, MASS1, USH2B, USH2C, VLGR1, VLGR1b
Human Chr (Location)  5q13; chr5:90558800-91164216 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human GPR98
Alleles
and
phenotypes
All alleles(9) : Targeted(4) Gene trapped(3) Spontaneous(1) Chemically induced(1)
 
Homozygotes for a spontaneous and a targeted mutation exhibit high sensitivity to audiogenic seizures. Targeted mutant mice lack the ankle links that connect growing stereocilia in the developing cochlear hair cells.
 
Human Diseases Modeled Using Mouse Gpr98 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cell-cell adhesion, cell communication, ...
Component cell surface, cytoplasm, ...
Function calcium ion binding, G-protein coupled receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (107)    Tissues (60)    Images (35)
Theiler Stages: 9, 12, 13, 15, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 107
cDNA source data(52)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(55) cDNA(54) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000032905 (Evidence)
Ensembl Gene ModelENSMUSG00000069170 (Evidence)
Entrez Gene110789 (Evidence)
UniGene288694
DFCITC1582764, TC1591299, TC1594975, TC1596821, TC1650418
DoTSDT.101269446, DT.103567746, DT.40144838, DT.55151072, DT.55168455, DT.91572337, DT.94153750, DT.94295425, DT.94295426, DT.94295427
NIA Mouse Gene IndexU034992
Consensus CDS ProjectCCDS36737.1
International Mouse Knockout Project StatusGpr98
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032905 VEGA Gene Model | MGI Sequence Detail 538087 C57BL/6J ±  kb
transcript OTTMUST00000081991 VEGA | MGI Sequence Detail 19338 Not Applicable 
polypeptide OTTMUSP00000043923 VEGA | MGI Sequence Detail 6298 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(11) UniProt(11)
Polymorphisms SNPs within 2kb(2839 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2841)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR009039 EAR
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR026919 G protein-coupled receptor 98
InterPro IPR000203 GPS domain
InterPro IPR005492 Leucine-rich glioma-inactivated , EPTP repeat
InterPro IPR003644 Na-Ca exchanger/integrin-beta4
Protein Ontology PR:000008191 G-protein coupled receptor 98
References (Earliest) J:25341 Frings H, et al., The production of stocks of albino mice with predictable susceptibilities to audiogenic seizures. Behaviour. 1953;5:305-19
(Latest) J:202979 Shin D, et al., Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Galphas/Galphaq-mediated protein kinases A/C. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19101-6
All references(52)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory