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Adgrv1
Gene Detail
Symbol

Name
ID
Adgrv1
adhesion G protein-coupled receptor V1
MGI:1274784
Synonyms
Gpr98, Mass1, Mgr1, Neurepin, VLGR1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
42.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:81095068-81633154 bp, - strand
From VEGA annotation of GRCm38

  538087 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19815  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADGRV1
Gene Tree: Adgrv1

Human
homologs
ADGRV1, adhesion G protein-coupled receptor V1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 84059
neXtProt AC: NX_Q8WXG9

Human Synonyms: FEB4, GPR98, MASS1, USH2B, USH2C, VLGR1, VLGR1b

Human Chr (Location): 5q13; chr5:90558800-91164223 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ADGRV1

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Gene trapped(3) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a spontaneous and a targeted mutation exhibit high sensitivity to audiogenic seizures. Targeted mutant mice lack the ankle links that connect growing stereocilia in the developing cochlear hair cells.
 
Human Diseases Modeled in Mice Using Adgrv1 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Adgrv1 interacts with 476 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process cell communication, cell surface receptor signaling pathway, ...
Component cell surface, cytoplasm, ...
Function calcium ion binding, G-protein coupled receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (107)    Tissues (60)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 107
cDNA source data(52)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gpr98 ; ZFIN adgrv1    NEW 
Molecular
reagents
All nucleic(55) cDNA(54) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000032905 (Evidence)
Ensembl Gene Model ENSMUSG00000069170 (Evidence)
Entrez Gene 110789 (Evidence)
UniGene 288694
DFCI TC1591299, TC1582764, TC1650418, TC1596821, TC1594975
DoTS DT.94295427, DT.94295426, DT.101269446, DT.94295425, DT.40144838, DT.103567746, DT.91572337, DT.94153750, DT.55168455, DT.55151072
NIA Mouse Gene Index U034992
Consensus CDS Project CCDS36737.1
International Mouse Phenotyping Consortium Status Adgrv1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032905 VEGA Gene Model | MGI Sequence Detail 538087 C57BL/6J ±  kb
transcript OTTMUST00000081991 VEGA | MGI Sequence Detail 19338 Not Applicable 
polypeptide OTTMUSP00000043923 VEGA | MGI Sequence Detail 6298 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(15) UniProt(7)
Polymorphisms
SNPs within 2kb(2839 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2841)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR009039 EAR
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR026919 G protein-coupled receptor 98
InterPro IPR000203 GPS domain
InterPro IPR005492 Leucine-rich glioma-inactivated , EPTP repeat
InterPro IPR003644 Na-Ca exchanger/integrin-beta4
Protein Ontology PR:000008191 G-protein coupled receptor 98
References
(Earliest) J:25341 Frings H, et al., The production of stocks of albino mice with predictable susceptibilities to audiogenic seizures. Behaviour. 1953;5:305-19
(Latest) J:218304 Hamann J, et al., International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein-Coupled Receptors. Pharmacol Rev. 2015 Apr;67(2):338-67
All references(57)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory