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Gene Detail
G protein-coupled receptor 98
Synonyms Mass1, Mgr1, Neurepin, VLGR1
Feature Type protein coding gene
Genetic Map
Chromosome 13
42.18 cM
Detailed Genetic Map ± 1 cM

Mapping data(5)
Sequence Map
Chr13:81095068-81633154 bp, - strand
From VEGA annotation of GRCm38

  538087 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:19815  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gpr98

Human Homolog GPR98, G protein-coupled receptor 98
NCBI Gene ID 84059
neXtProt AC  NX_Q8WXG9
Human Synonyms  FEB4, MASS1, USH2B, USH2C, VLGR1, VLGR1b
Human Chr (Location)  5q13; chr5:90558800-91164216 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human GPR98
alleles, and
All mutations/alleles(9) : Chemically induced (ENU)(1) Gene trapped(3) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for a spontaneous and a targeted mutation exhibit high sensitivity to audiogenic seizures. Targeted mutant mice lack the ankle links that connect growing stereocilia in the developing cochlear hair cells.
Human Diseases Modeled Using Mouse Gpr98 (1)    Alleles Annotated to Human Diseases(2)   
Gpr98 interacts with 477 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
All GO classifications: (40 annotations)
Process cell communication, cell surface receptor signaling pathway, ...
Component cell surface, cytoplasm, ...
Function calcium ion binding, G-protein coupled receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (8 records)
Data Summary: Results (107)    Tissues (60)    Images (35)
Theiler Stages: 9, 12, 13, 15, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 107
cDNA source data(52)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(55) cDNA(54) Other(1)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000032905 (Evidence)
Ensembl Gene ModelENSMUSG00000069170 (Evidence)
Entrez Gene110789 (Evidence)
DFCITC1582764, TC1591299, TC1594975, TC1596821, TC1650418
DoTSDT.101269446, DT.103567746, DT.40144838, DT.55151072, DT.55168455, DT.91572337, DT.94153750, DT.94295425, DT.94295426, DT.94295427
NIA Mouse Gene IndexU034992
Consensus CDS ProjectCCDS36737.1
International Mouse Knockout Project StatusGpr98
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032905 VEGA Gene Model | MGI Sequence Detail 538087 C57BL/6J ±  kb
transcript OTTMUST00000081991 VEGA | MGI Sequence Detail 19338 Not Applicable 
polypeptide OTTMUSP00000043923 VEGA | MGI Sequence Detail 6298 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(11) UniProt(11)
Polymorphisms SNPs within 2kb(2839 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2841)
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR009039 EAR
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR026919 G protein-coupled receptor 98
InterPro IPR000203 GPS domain
InterPro IPR005492 Leucine-rich glioma-inactivated , EPTP repeat
InterPro IPR003644 Na-Ca exchanger/integrin-beta4
Protein Ontology PR:000008191 G-protein coupled receptor 98
References (Earliest) J:25341 Frings H, et al., The production of stocks of albino mice with predictable susceptibilities to audiogenic seizures. Behaviour. 1953;5:305-19
(Latest) J:209073 Zou J, et al., Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice. Hum Mol Genet. 2014 May 1;23(9):2374-90
All references(56)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory