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Adgrv1 Gene Detail
Summary
  • Symbol
    Adgrv1
  • Name
    adhesion G protein-coupled receptor V1
  • Synonyms
    Gpr98, Mass1, Mgr1, Neurepin, VLGR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1274784
    NCBI Gene: 110789
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:81243187-81781273 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 42.18 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16837 from dbSNP Build 142
  • Strain Annotations
    40
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1274784
 protein coding gene Chr13:81243187-81781504 (-)
129S1/SvImJ ENSMUSG00200005888
 protein coding gene Chr13:76166606-76222311 (-)
129S1/SvImJ ENSMUSGG00200054745
 protein coding gene Chr13:76094883-76159809 (-)
129S1/SvImJ ENSMUSGG00200054748
 protein coding gene Chr13:75682356-75870754 (-)
A/J ENSMUSGG00195055329
 protein coding gene Chr13:76192315-76380725 (-)
A/J ENSMUSG00195024630
 protein coding gene Chr13:76677079-76732778 (-)
A/J ENSMUSGG00195055328
 protein coding gene Chr13:76605306-76670283 (-)
AKR/J ENSMUSG00220016368
 protein coding gene Chr13:75223582-75279290 (-)
AKR/J ENSMUSGG00220054736
 protein coding gene Chr13:75151879-75216786 (-)
AKR/J ENSMUSGG00220054735
 protein coding gene Chr13:74739520-74927738 (-)
BALB/cJ ENSMUSG00180001330
 protein coding gene Chr13:77179765-77235466 (-)
BALB/cJ ENSMUSGG00180055522
 protein coding gene Chr13:76695037-76883453 (-)
C3H/HeJ ENSMUSGG00175054920
 protein coding gene Chr13:76940170-77129365 (-)
C3H/HeJ ENSMUSGG00175054737
 protein coding gene Chr13:77353498-77418429 (-)
C3H/HeJ ENSMUSG00175018818
 protein coding gene Chr13:77425225-77480929 (-)
C57BL/6NJ ENSMUSG00215002495
 protein coding gene Chr13:77305202-77360908 (-)
C57BL/6NJ ENSMUSGG00215055679
 protein coding gene Chr13:77233483-77298404 (-)
C57BL/6NJ ENSMUSGG00215055613
 protein coding gene Chr13:76820897-77009315 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018743
 protein coding gene Chr13:75495172-75993002 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054831
 protein coding gene Chr13:76230213-76419407 (-)
CBA/J ENSMUSG00210005546
 protein coding gene Chr13:76715248-76770953 (-)
CBA/J ENSMUSGG00210054839
 protein coding gene Chr13:76643530-76708452 (-)
DBA/2J ENSMUSGG00185057412
 protein coding gene Chr13:80323758-80388679 (-)
DBA/2J ENSMUSG00185016858
 protein coding gene Chr13:80395475-80451183 (-)
DBA/2J ENSMUSGG00185057764
 protein coding gene Chr13:79910508-80099712 (-)
FVB/NJ ENSMUSGG00205054434
 protein coding gene Chr13:76091580-76156508 (-)
FVB/NJ ENSMUSGG00205054432
 protein coding gene Chr13:75679004-75867428 (-)
FVB/NJ ENSMUSG00205012602
 protein coding gene Chr13:76163306-76219008 (-)
JF1/MsJ ENSUMUG00000028813
 protein coding gene Chr13:79683704-80232686 (-)
LP/J ENSMUSGG00230055540
 protein coding gene Chr13:89897074-90085479 (-)
LP/J ENSMUSGG00230055574
 protein coding gene Chr13:90308941-90373871 (-)
LP/J ENSMUSG00230023376
 protein coding gene Chr13:90380667-90436359 (-)
NOD/ShiLtJ ENSMUSGG00190054900
 protein coding gene Chr13:76241353-76434421 (-)
NOD/ShiLtJ ENSMUSGG00190054901
 protein coding gene Chr13:76658491-76723406 (-)
NOD/ShiLtJ ENSMUSG00190007993
 protein coding gene Chr13:76730201-76785905 (-)
NZO/HlLtJ ENSMUSGG00225055533
 protein coding gene Chr13:82827373-82892306 (-)
NZO/HlLtJ ENSMUSG00225030211
 protein coding gene Chr13:82899102-82954798 (-)
NZO/HlLtJ ENSMUSGG00225055532
 protein coding gene Chr13:82414851-82603263 (-)
PWK/PhJ ENSLUMG00010014046
 protein coding gene Chr13:75794740-76346170 (-)
SPRET/EiJ ENSMSPG00010001245
 protein coding gene Chr13:76684986-77239122 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ADGRV1, adhesion G protein-coupled receptor V1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRV1, adhesion G protein-coupled receptor V1
  • Synonyms
    FEB4, GPR98, MASS1, USH2B, USH2C, VLGR1, VLGR1b
  • Links
    NCBI Gene ID: 84059
    UniProt: Q8WXG9

  • Chr Location
    5q14.3; chr5:90529344-91164437 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Adgrv1 mouse models; 2 with human ADGRV1 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 8 alleles in 10 genetic backgrounds
    2 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous and a targeted mutation exhibit high sensitivity to audiogenic seizures. Targeted mutant mice lack the ankle links that connect growing stereocilia in the developing cochlear hair cells. Homozygous KO mice are deaf. Homozygosity for the c.6748Gdel deletion leads to Usher syndrome type 2C.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    81
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    84
  • cDNA Data
    55
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000069170 Ensembl Gene Model | MGI Sequence Detail 538087 C57BL/6J ±  kb
    transcript ENSMUST00000095585 Ensembl | MGI Sequence Detail 19338 Not Applicable  
    polypeptide ENSMUSP00000093245 Ensembl | MGI Sequence Detail 6298 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 57
      Primer pair 6
      Other 1
      Antibodies 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 13
      Diseases 3
      Gene Ontology 28
      Phenotypes 45
    • Earliest
      J:25341 Frings H, et al., The production of stocks of albino mice with predictable susceptibilities to audiogenic seizures. Behaviour. 1953;5(1):305-19
    • Latest
      J:375698 Yang Z, et al., A force-sensitive adhesion GPCR is required for equilibrioception. Cell Res. 2025 Apr;35(4):243-264
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory