Gpr98
Gene Detail

Symbol Name ID

Gpr98 G protein-coupled receptor 98 MGI:1274784

Synonyms

Mass1, Mgr1, Neurepin, VLGR1

Feature Type

protein coding gene

Genetic Map

Chromosome 13

42.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr13:81095068-81633154 bp, - strand From VEGA annotation of GRCm38   538087 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:19815  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gpr98

Human homologs

Human Homolog		GPR98, G protein-coupled receptor 98
NCBI Gene ID		84059
neXtProt AC		NX_Q8WXG9
Human Synonyms		FEB4, MASS1, USH2B, USH2C, VLGR1, VLGR1b
Human Chr (Location)		5q13; chr5:89854617-90460033 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human GPR98

Alleles and phenotypes

All alleles(9) : Targeted(4) Gene trapped(3) Spontaneous(1) Chemically induced(1)
 

Homozygotes for a spontaneous and a targeted mutation exhibit high sensitivity to audiogenic seizures. Targeted mutant mice lack the ankle links that connect growing stereocilia in the developing cochlear hair cells.

 
Human Diseases Modeled Using Mouse Gpr98 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	cell-cell adhesion, cell communication, ...
Component	cell surface, cytoplasm, ...
Function	calcium ion binding, G-protein coupled receptor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (107)    Tissues (60)    Images (35)
Theiler Stages: 9, 12, 13, 15, 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	107

cDNA source data(52)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(55) cDNA(54) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000032905 (Evidence)
Ensembl Gene Model	ENSMUSG00000069170 (Evidence)
Entrez Gene	110789 (Evidence)
UniGene	288694
DFCI	TC1582764, TC1591299, TC1594975, TC1596821, TC1650418
DoTS	DT.101269446, DT.103567746, DT.40144838, DT.55151072, DT.55168455, DT.91572337, DT.94153750, DT.94295425, DT.94295426, DT.94295427
NIA Mouse Gene Index	U034992
Consensus CDS Project	CCDS36737.1
International Mouse Knockout Project Status	Gpr98

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032905	VEGA Gene Model | MGI Sequence Detail	538087	C57BL/6J
transcript	OTTMUST00000081991	VEGA | MGI Sequence Detail	19338	Not Applicable
polypeptide	OTTMUSP00000043923	VEGA | MGI Sequence Detail	6298	Not Applicable

All sequences(87) RefSeq(2) UniProt(11)

Polymorphisms

SNPs(2660 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR009039	EAR
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR026919	G-protein coupled receptor 98
InterPro	IPR000203	GPS domain
InterPro	IPR005492	Leucine-rich glioma-inactivated , EPTP repeat
InterPro	IPR003644	Na-Ca exchanger/integrin-beta4
Protein Ontology	PR:000008191	G-protein coupled receptor 98

References

(Earliest) J:25341 Frings H, et al., The production of stocks of albino mice with predictable susceptibilities to audiogenic seizures. Behaviour. 1953;5:305-19
(Latest) J:190930 Zallocchi M, et al., Regulated vesicular trafficking of specific PCDH15 and VLGR1 variants in auditory hair cells. J Neurosci. 2012 Oct 3;32(40):13841-59
All references(50)