Alox12b
Gene Detail

Symbol Name ID

Alox12b arachidonate 12-lipoxygenase, 12R type MGI:1274782

Synonyms

12R-LOX, Aloxe2, e-LOX2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:69156989-69169792 bp, + strand From VEGA annotation of GRCm38   12804 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:884  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: arachidonate 5-lipoxygenase
Gene Tree: Alox12b

Human homologs

Human Homolog		ALOX12B, arachidonate 12-lipoxygenase, 12R type
NCBI Gene ID		242
neXtProt AC		NX_O75342
Human Synonyms		12R-LOX, ARCI2
Human Chr (Location)		17p13.1; chr17:7975954-7991021 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ALOX12B

Alleles and phenotypes

All alleles(5) : Targeted(4) Chemically induced(1)
 

Neonatal homozygous mutant mice exhibit reddened skin that quickly dehydrates and appears scaly. The epidermis is hyperkeratotic, and its permeability barrier function is compromised. Homozygotes die within 24 hours of birth.

 
Human Diseases Modeled Using Mouse Alox12b (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	leukotriene biosynthetic process, leukotriene metabolic process, ...
Function	arachidonate 12-lipoxygenase activity, iron ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (120)    Tissues (114)    Images (10)
Theiler Stages: 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	104
Northern blot	13
RT-PCR	3

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(3) cDNA(13) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005964 (Evidence)
Ensembl Gene Model	ENSMUSG00000032807 (Evidence)
Entrez Gene	11686 (Evidence)
UniGene	340329
DFCI	TC1582646
DoTS	DT.489219
NIA Mouse Gene Index	U012813
EC	1.13.11.-
Consensus CDS Project	CCDS24885.1
International Mouse Knockout Project Status	Alox12b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005964	VEGA Gene Model | MGI Sequence Detail	12804	C57BL/6J
transcript	OTTMUST00000013318	VEGA | MGI Sequence Detail	2431	Not Applicable
polypeptide	OTTMUSP00000006168	VEGA | MGI Sequence Detail	701	Not Applicable

All sequences(20) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(82 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008976	Lipase/lipooxygenase, PLAT/LH2
InterPro	IPR000907	Lipoxygenase
InterPro	IPR020834	Lipoxygenase, conserved site
InterPro	IPR013819	Lipoxygenase, C-terminal
InterPro	IPR020833	Lipoxygenase, iron binding site
InterPro	IPR001024	Lipoxygenase, LH2
InterPro	IPR001885	Lipoxygenase, mammalian
Protein Ontology	PR:000003958	arachidonate 12-lipoxygenase, 12R-type

References

(Earliest) J:46809 Krieg P, et al., cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin. Biochim Biophys Acta. 1998 Mar 6;1391(1):7-12
(Latest) J:174794 Zheng Y, et al., Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope. J Biol Chem. 2011 Jul 8;286(27):24046-56
All references(40)

Other accession IDs

MGI:1206580