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Alox12b Gene Detail
Summary
  • Symbol
    Alox12b
  • Name
    arachidonate 12-lipoxygenase, 12R type
  • Synonyms
    12R-LOX, Aloxe2, e-LOX2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1274782
    NCBI Gene: 11686
  • Gene Overview
    MyGene.info: ALOX12B
Location & Maps
more
  • Sequence Map
    Chr11:69156989-69169792 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12804 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.38 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ALOX12B, arachidonate 12-lipoxygenase, 12R type
  • Vertebrate Orthologs
    6
  • Human Ortholog
    ALOX12B, arachidonate 12-lipoxygenase, 12R type
    Orthology source: HomoloGene, HGNC
  • Synonyms
    12R-LOX, ARCI2
  • Links
    NCBI Gene ID: 242
    neXtProt AC: NX_O75342

  • Chr Location
    17p13.1; chr17:8072636-8087703 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Alox12b mouse models; 1 with human ALOX12B associations

Human Disease Mouse Models
       Ichthyosis, Congenital, Autosomal Recessive 2; ARCI2   OMIM: 242100 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    4 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Alox12b
  • Incidental Mutations
Neonatal homozygous mutant mice exhibit reddened skin that quickly dehydrates and appears scaly. The epidermis is hyperkeratotic, and its permeability barrier function is compromised. Homozygotes die within 24 hours of birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005964 VEGA Gene Model | MGI Sequence Detail 12804 C57BL/6J ±  kb
transcript OTTMUST00000013318 VEGA | MGI Sequence Detail 2431 Not Applicable  
polypeptide OTTMUSP00000006168 VEGA | MGI Sequence Detail 701 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    183 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 3
    cDNA 14
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1206580
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:46809 Krieg P, et al., cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin. Biochim Biophys Acta. 1998 Mar 6;1391(1):7-12
  • Latest
    J:196489 Krieg P, et al., Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation. J Invest Dermatol. 2013 Jan;133(1):172-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory