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Alox12b
Gene Detail
Symbol

Name
ID
Alox12b
arachidonate 12-lipoxygenase, 12R type
MGI:1274782
Synonyms
12R-LOX, Aloxe2, e-LOX2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:69156989-69169792 bp, + strand
From VEGA annotation of GRCm38

  12804 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:884  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: arachidonate 5-lipoxygenase
Gene Tree: Alox12b

Human
homologs
Human Homolog ALOX12B, arachidonate 12-lipoxygenase, 12R type
NCBI Gene ID 242
neXtProt AC  NX_O75342
Human Synonyms  12R-LOX, ARCI2
Human Chr (Location)  17p13.1; chr17:8072636-8087703 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ALOX12B
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Neonatal homozygous mutant mice exhibit reddened skin that quickly dehydrates and appears scaly. The epidermis is hyperkeratotic, and its permeability barrier function is compromised. Homozygotes die within 24 hours of birth.
 
Human Diseases Modeled Using Mouse Alox12b (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)
Interactions
Alox12b interacts with 23 markers (Mir26b, Mir33, Mir34a, ...)
Expression
Literature Summary: (5 records)
Data Summary: Results (120)    Tissues (115)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 104
Northern blot 13
RT-PCR 3
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(3) cDNA(14) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005964 (Evidence)
Ensembl Gene ModelENSMUSG00000032807 (Evidence)
Entrez Gene11686 (Evidence)
UniGene340329
DFCITC1582646
DoTSDT.489219
NIA Mouse Gene IndexU012813
EC1.13.11.-
Consensus CDS ProjectCCDS24885.1
International Mouse Knockout Project StatusAlox12b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005964 VEGA Gene Model | MGI Sequence Detail 12804 C57BL/6J ±  kb
transcript OTTMUST00000013318 VEGA | MGI Sequence Detail 2431 Not Applicable 
polypeptide OTTMUSP00000006168 VEGA | MGI Sequence Detail 701 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(191 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008976 Lipase/lipooxygenase, PLAT/LH2
InterPro IPR000907 Lipoxygenase
InterPro IPR020834 Lipoxygenase, conserved site
InterPro IPR013819 Lipoxygenase, C-terminal
InterPro IPR020833 Lipoxygenase, iron binding site
InterPro IPR001024 Lipoxygenase, LH2
InterPro IPR001885 Lipoxygenase, mammalian
Protein Ontology PR:000003958 arachidonate 12-lipoxygenase, 12R-type
References
(Earliest) J:46809 Krieg P, et al., cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin. Biochim Biophys Acta. 1998 Mar 6;1391(1):7-12
(Latest) J:196489 Krieg P, et al., Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation. J Invest Dermatol. 2013 Jan;133(1):172-80
All references(44)
Disease annotation references (1)
Other
accession IDs
MGI:1206580

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory