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Alox12b
Gene Detail
Symbol

Name
ID
Alox12b
arachidonate 12-lipoxygenase, 12R type
MGI:1274782
Synonyms
12R-LOX, Aloxe2, e-LOX2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:69156989-69169792 bp, + strand
From VEGA annotation of GRCm38

  12804 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:884  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: ALOX12B
Protein SuperFamily: arachidonate 5-lipoxygenase
Gene Tree: Alox12b

Human
homologs
ALOX12B, arachidonate 12-lipoxygenase, 12R type
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 242
neXtProt AC: NX_O75342

Human Synonyms: 12R-LOX, ARCI2

Human Chr (Location): 17p13.1; chr17:8072636-8087703 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ALOX12B

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Neonatal homozygous mutant mice exhibit reddened skin that quickly dehydrates and appears scaly. The epidermis is hyperkeratotic, and its permeability barrier function is compromised. Homozygotes die within 24 hours of birth.
 
Human Diseases Modeled in Mice Using Alox12b (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Alox12b interacts with 23 markers (Mir26b, Mir33, Mir34a, ...)
Expression
Literature Summary: (5 records)
Data Summary: Results (120)    Tissues (115)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 104
Northern blot 13
RT-PCR 3
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase alox12b    NEW 
Molecular
reagents
All nucleic(18) Genomic(3) cDNA(14) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005964 (Evidence)
Ensembl Gene Model ENSMUSG00000032807 (Evidence)
Entrez Gene 11686 (Evidence)
UniGene 340329
DFCI TC1582646
DoTS DT.489219
NIA Mouse Gene Index U012813
EC 1.13.11.-
Consensus CDS Project CCDS24885.1
International Mouse Phenotyping Consortium Status Alox12b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005964 VEGA Gene Model | MGI Sequence Detail 12804 C57BL/6J ±  kb
transcript OTTMUST00000013318 VEGA | MGI Sequence Detail 2431 Not Applicable 
polypeptide OTTMUSP00000006168 VEGA | MGI Sequence Detail 701 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(191 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000907 Lipoxygenase
InterPro IPR020834 Lipoxygenase, conserved site
InterPro IPR013819 Lipoxygenase, C-terminal
InterPro IPR020833 Lipoxygenase, iron binding site
InterPro IPR001885 Lipoxygenase, mammalian
InterPro IPR001024 PLAT/LH2 domain
Protein Ontology PR:000003958 arachidonate 12-lipoxygenase, 12R-type
References
(Earliest) J:46809 Krieg P, et al., cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin. Biochim Biophys Acta. 1998 Mar 6;1391(1):7-12
(Latest) J:196489 Krieg P, et al., Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation. J Invest Dermatol. 2013 Jan;133(1):172-80
All references(43)
Disease annotation references (1)
Other
accession IDs
MGI:1206580

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory