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Axin2
Gene Detail
 Symbol
Name
ID
Axin2
axin2
MGI:1270862
Synonyms Axil, Conductin
Feature Type protein coding gene
Genetic Map
Chromosome 11
71.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:108920349-108950783 bp, + strand
From VEGA annotation of GRCm38

  30435 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3420  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: axis inhibition protein (axin)
Gene Tree: Axin2

Human
homologs
Human Homolog AXIN2, axin 2
NCBI Gene ID 8313
neXtProt AC  NX_Q9Y2T1
Human Synonyms  AXIL, ODCRCS
Human Chr (Location)  17q23-q24; chr17:65528563-65561648 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human AXIN2
Alleles
and
phenotypes
All alleles(7) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit premature fusion of cranial sutures, enhanced expansion of osteoprogenitors, accelerated ossification, and increased osteoblast proliferation and differentiation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process bone mineralization, cell death, ...
Component beta-catenin destruction complex, cell cortex, ...
Function armadillo repeat domain binding, beta-catenin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (207 records)
Data Summary: Results (945)    Tissues (417)    Images (121)
Theiler Stages: 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 811
In situ reporter (knock in) 106
Northern blot 7
RT-PCR 21
cDNA source data(58)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(61) cDNA(59) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000003199 (Evidence)
Ensembl Gene ModelENSMUSG00000000142 (Evidence)
Entrez Gene12006 (Evidence)
UniGene71710
DFCITC1577803
DoTSDT.101130941, DT.485651
NIA Mouse Gene IndexU013488
Consensus CDS ProjectCCDS25575.1
International Mouse Knockout Project StatusAxin2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003199 VEGA Gene Model | MGI Sequence Detail 30435 C57BL/6J ±  kb
transcript OTTMUST00000006621 VEGA | MGI Sequence Detail 4260 Not Applicable 
polypeptide OTTMUSP00000003133 VEGA | MGI Sequence Detail 840 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(10) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014936 Axin beta-catenin binding
InterPro IPR001158 DIX domain
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000004527 axin-2
References (Earliest) J:47363 Behrens J, et al., Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science. 1998 Apr 24;280(5363):596-9
(Latest) J:208417 Carraro G, et al., miR-142-3p balances proliferation and differentiation of mesenchymal cells during lung development. Development. 2014 Mar;141(6):1272-81
All references(296)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory