Cry2
Gene Detail

Symbol Name ID

Cry2 cryptochrome 2 (photolyase-like) MGI:1270859

Synonyms

D130054K12Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

51.01 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:92403646-92434043 bp, - strand From VEGA annotation of GRCm38   30398 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56466  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: deoxyribodipyrimidine photo-lyase
Gene Tree: Cry2

Human homologs

Human Homolog		CRY2, cryptochrome 2 (photolyase-like)
NCBI Gene ID		1408
neXtProt AC		NX_Q49AN0
Human Synonyms		HCRY2, PHLL2
Human Chr (Location)		11p11.2; chr11:45868669-45904799 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(5) Gene trapped(5)
 

Homozygotes for targeted null mutations exhibit a one-hour longer circadian period under constant darkness, and reduced expression of another circadian gene in the suprachiasmatic nucleus in response to acute light exposure.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	circadian rhythm, DNA repair, ...
Component	cytoplasm, mitochondrion, ...
Function	damaged DNA binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (109)    Tissues (101)    Images (17)
Theiler Stages: 17, 22, 28

Assay Type	Results
RNA in situ	93
RT-PCR	16

cDNA source data(66)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(72) Genomic(3) cDNA(67) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000014483 (Evidence)
Ensembl Gene Model	ENSMUSG00000068742 (Evidence)
Entrez Gene	12953 (Evidence)
UniGene	254181
DFCI	TC1576347, TC1595098, TC1620806
DoTS	DT.489206, DT.91561139, DT.91594099
NIA Mouse Gene Index	U023036
Consensus CDS Project	CCDS16447.1
International Mouse Knockout Project Status	Cry2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014483	VEGA Gene Model | MGI Sequence Detail	30398	C57BL/6J
transcript	OTTMUST00000034401	VEGA | MGI Sequence Detail	2160	Not Applicable
polypeptide	OTTMUSP00000015409	VEGA | MGI Sequence Detail	592	Not Applicable

All sequences(43) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(102 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005101	DNA photolyase, FAD-binding/Cryptochrome, C-terminal
InterPro	IPR006050	DNA photolyase, N-terminal
InterPro	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Protein Ontology	PR:000005906	cryptochrome-2

References

(Earliest) J:44595 van Noort JM, et al., The small heat-shock protein alpha B-crystallin as candidate autoantigen in multiple sclerosis [see comments]. Nature. 1995 Jun 29;375(6534):798-801
(Latest) J:194495 Jouffe C, et al., The circadian clock coordinates ribosome biogenesis. PLoS Biol. 2013;11(1):e1001455
All references(115)

Other accession IDs

MGI:2139231, MGI:2444176