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Cry2
Gene Detail
 Symbol
Name
ID
Cry2
cryptochrome 2 (photolyase-like)
MGI:1270859
Synonyms D130054K12Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
51.01 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:92403646-92434043 bp, - strand
From VEGA annotation of GRCm38

  30398 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56466  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: deoxyribodipyrimidine photo-lyase
Gene Tree: Cry2

Human
homologs
Human Homolog CRY2, cryptochrome circadian clock 2
NCBI Gene ID 1408
neXtProt AC  NX_Q49AN0
Human Synonyms  HCRY2, PHLL2
Human Chr (Location)  11p11.2; chr11:45847118-45883248 (+)  GRCh38
Alleles
and
phenotypes
All alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit a one-hour longer circadian period under constant darkness, and reduced expression of another circadian gene in the suprachiasmatic nucleus in response to acute light exposure.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process circadian regulation of gene expression, circadian rhythm, ...
Component cell, cytoplasm, ...
Function damaged DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (109)    Tissues (101)    Images (17)
Theiler Stages: 17, 22, 28
Assay TypeResults
RNA in situ 93
RT-PCR 16
cDNA source data(66)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(72) Genomic(3) cDNA(67) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014483 (Evidence)
Ensembl Gene ModelENSMUSG00000068742 (Evidence)
Entrez Gene12953 (Evidence)
UniGene254181
DFCITC1576347, TC1595098, TC1620806
DoTSDT.489206, DT.91561139, DT.91594099
NIA Mouse Gene IndexU023036
PDB4I6E, 4I6G, 4I6J, 4MLP
Consensus CDS ProjectCCDS16447.1
International Mouse Knockout Project StatusCry2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014483 VEGA Gene Model | MGI Sequence Detail 30398 C57BL/6J ±  kb
transcript OTTMUST00000034401 VEGA | MGI Sequence Detail 2160 Not Applicable 
polypeptide OTTMUSP00000015409 VEGA | MGI Sequence Detail 592 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(228 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005101 DNA photolyase, FAD-binding/Cryptochrome, C-terminal
InterPro IPR006050 DNA photolyase, N-terminal
InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Protein Ontology PR:000005906 cryptochrome-2
References (Earliest) J:44595 van Noort JM, et al., The small heat-shock protein alpha B-crystallin as candidate autoantigen in multiple sclerosis [see comments]. Nature. 1995 Jun 29;375(6534):798-801
(Latest) J:209571 Goriki A, et al., A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 2014 Apr;12(4):e1001839
All references(141)
Other
accession IDs
MGI:2139231, MGI:2444176

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory