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Cry2 Gene Detail
Summary
  • Symbol
    Cry2
  • Name
    cryptochrome 2 (photolyase-like)
  • Synonyms
    D130054K12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270859
    NCBI Gene: 12953
  • Gene Overview
    MyGene.info: CRY2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:92403646-92434043 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 51.01 cM, cytoband E
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    228 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270859
protein coding gene Chr2:92403646-92434214 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026168
protein coding gene Chr2:93834283-93864666 (-)
A/J MGP_AJ_G0026129
protein coding gene Chr2:90037410-90067771 (-)
AKR/J MGP_AKRJ_G0026110
protein coding gene Chr2:92529024-92559392 (-)
BALB/cJ MGP_BALBcJ_G0026138
protein coding gene Chr2:90222714-90253091 (-)
C3H/HeJ MGP_C3HHeJ_G0025889
protein coding gene Chr2:92832414-92862852 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026589
protein coding gene Chr2:97049968-97080352 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023980
protein coding gene Chr2:86529526-86561488 (-)
CAST/EiJ MGP_CASTEiJ_G0025354
protein coding gene Chr2:93380007-93411022 (-)
CBA/J MGP_CBAJ_G0025867
protein coding gene Chr2:100435771-100466158 (-)
DBA/2J MGP_DBA2J_G0026003
protein coding gene Chr2:89630564-89660923 (-)
FVB/NJ MGP_FVBNJ_G0025966
protein coding gene Chr2:88742079-88773107 (-)
LP/J MGP_LPJ_G0026107
protein coding gene Chr2:94031407-94061880 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025992
protein coding gene Chr2:103397568-103427959 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026643
protein coding gene Chr2:92610104-92645821 (-)
PWK/PhJ MGP_PWKPhJ_G0025089
protein coding gene Chr2:89376246-89407379 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024890
protein coding gene Chr2:92182791-92215094 (-)
WSB/EiJ MGP_WSBEiJ_G0025421
protein coding gene Chr2:93232885-93264299 (-)



Homology
more
  • Human Ortholog
    CRY2, cryptochrome circadian regulator 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRY2, cryptochrome circadian regulator 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HCRY2, PHLL2
  • Links
    NCBI Gene ID: 1408
    neXtProt AC: NX_Q49AN0
    UniProt: Q49AN0

  • Chr Location
    11p11.2; chr11:45847118-45883248 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 2 genetic backgrounds
    40 phenotypes from multigenic genotypes
    1 images
    107 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit a one-hour longer circadian period under constant darkness, and reduced expression of another circadian gene in the suprachiasmatic nucleus in response to acute light exposure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068742 Ensembl Gene Model | MGI Sequence Detail 30398 C57BL/6J ±  kb
    transcript ENSMUST00000111278 Ensembl | MGI Sequence Detail 2160 Not Applicable  
    polypeptide ENSMUSP00000106909 Ensembl | MGI Sequence Detail 592 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • PDB
    • InterPro Domains
      IPR005101 Cryptochrome/DNA photolyase, FAD-binding domain
      IPR036134 Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily
      IPR036155 Cryptochrome/photolyase, N-terminal domain superfamily
      IPR006050 DNA photolyase, N-terminal
      IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    Molecular
    Reagents
    less
    • All nucleic 73
      Genomic 3
      cDNA 67
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139231, MGI:2444176
    References
    more
    • Summaries
      All 181
      Developmental Gene Expression 6
      Gene Ontology 33
      Phenotypes 107
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:261478 Mei L, et al., Long-term in vivo recording of circadian rhythms in brains of freely moving mice. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4276-4281

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory