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Il16
Gene Detail
Symbol

Name
ID
Il16
interleukin 16
MGI:1270855
Feature Type
protein coding gene
Genetic Map
Chromosome 7
47.43 cM, cytoband D2-D3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:83642848-83745726 bp, - strand
From VEGA annotation of GRCm38

  102879 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18157  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: interleukin-16
Gene Tree: Il16

Human
homologs
Human Homolog IL16, interleukin 16
NCBI Gene ID 3603
neXtProt AC  NX_Q14005
Human Synonyms  LCF, NIL16, prIL-16, PRIL16
Human Chr (Location)  15q26.3; chr15:81182600-81312763 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display a transient but consistent increase of thymidine incorporation in anti-CD3-stimulated CD4+ T cells, but fail to show a hyperproliferative T cell phenotype using BrdU labeling.
 
Interactions
Il16 interacts with 243 markers (Mir7b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process chemotaxis, induction of positive chemotaxis, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (137)    Tissues (28)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 137
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(15)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000027337 (Evidence)
Ensembl Gene ModelENSMUSG00000001741 (Evidence)
Entrez Gene16170 (Evidence)
DFCITC1658304, TC1642904, TC1577608
NIA Mouse Gene IndexU028803
Consensus CDS ProjectCCDS21412.1
International Mouse Knockout Project StatusIl16
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027337 VEGA Gene Model | MGI Sequence Detail 102879 C57BL/6J ±  kb
transcript OTTMUST00000067590 VEGA | MGI Sequence Detail 5021 Not Applicable 
polypeptide OTTMUSP00000034032 VEGA | MGI Sequence Detail 1322 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(11) UniProt(7)
Polymorphisms
SNPs within 2kb(873 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020450 Interleukin-16
InterPro IPR001478 PDZ domain
Protein Ontology PR:000001374 interleukin-16
References
(Earliest) J:42322 Mohr AM, et al., Differential effects of acute hypoxia and endotoxin on the secretion and expression of bone marrow interleukin-1 and interleukin-6. Shock. 1997 May;7(5):324-31
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory