Il16
Gene Detail

Symbol Name ID

Il16 interleukin 16 MGI:1270855

Feature Type

protein coding gene

Genetic Map

Chromosome 7

47.43 cM, cytoband D2-D3
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr7:83642848-83745726 bp, - strand From VEGA annotation of GRCm38   102879 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:18157  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interleukin-16
Gene Tree: Il16

Human homologs

Human Homolog		IL16, interleukin 16
NCBI Gene ID		3603
neXtProt AC		NX_Q14005
Human Synonyms		LCF, NIL16, prIL-16, PRIL16
Human Chr (Location)		15q26.3; chr15:81489219-81605104 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-out allele display a transient but consistent increase of thymidine incorporation in anti-CD3-stimulated CD4+ T cells, but fail to show a hyperproliferative T cell phenotype using BrdU labeling.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	chemotaxis, induction of positive chemotaxis, ...
Component	cytoplasm, extracellular region, ...
Function	cytokine activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (137)    Tissues (28)    Images (60)
Theiler Stages: 23

Assay Type	Results
RNA in situ	137

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(1) cDNA(15)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000027337 (Evidence)
Ensembl Gene Model	ENSMUSG00000001741 (Evidence)
Entrez Gene	16170 (Evidence)
DFCI	TC1577608, TC1642904, TC1658304
NIA Mouse Gene Index	U028803
Consensus CDS Project	CCDS21412.1
International Mouse Knockout Project Status	Il16

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027337	VEGA Gene Model | MGI Sequence Detail	102879	C57BL/6J
transcript	OTTMUST00000067590	VEGA | MGI Sequence Detail	5021	Not Applicable
polypeptide	OTTMUSP00000034032	VEGA | MGI Sequence Detail	1322	Not Applicable

All sequences(48) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(602 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020450	Interleukin-16
InterPro	IPR001478	PDZ domain
Protein Ontology	PR:000001374	interleukin-16

References

(Earliest) J:42322 Mohr AM, et al., Differential effects of acute hypoxia and endotoxin on the secretion and expression of bone marrow interleukin-1 and interleukin-6. Shock. 1997 May;7(5):324-31
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(39)