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Guca2b
Gene Detail
Symbol

Name
ID
Guca2b
guanylate cyclase activator 2b (retina)
MGI:1270851
Synonyms
Gcap2, uroguanylin
Feature Type
protein coding gene
Genetic Map
Chromosome 4
55.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:119656607-119658954 bp, - strand
From VEGA annotation of GRCm38

  2348 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5150  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: guanylin
Gene Tree: Guca2b

Human
homologs
Human Homolog GUCA2B, guanylate cyclase activator 2B (uroguanylin)
NCBI Gene ID 2981
neXtProt AC  NX_Q16661
Human Synonyms  GCAP-II, UGN
Human Chr (Location)  1p34-p33; chr1:42153421-42155824 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
 
Homozygotes for a targeted null mutation exhibit elevated blood pressure, increased sodium levels, and reduced sodium, potassium, and fluid excretion following salt loading.
 
Interactions
Guca2b interacts with 26 markers (Mir30c-1, Mir30c-2, Mir92-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process body fluid secretion, cGMP biosynthetic process, ...
Component extracellular region, extracellular vesicular exosome
Function guanylate cyclase activator activity
External Resources: FuncBase
Expression
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) Genomic(3) cDNA(41)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000009464 (Evidence)
Ensembl Gene ModelENSMUSG00000032978 (Evidence)
Entrez Gene14916 (Evidence)
UniGene278
DFCITC1581820
DoTSDT.493983, DT.101278830, DT.110722222
Consensus CDS ProjectCCDS18587.1
International Mouse Knockout Project StatusGuca2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009464 VEGA Gene Model | MGI Sequence Detail 2348 C57BL/6J ±  kb
transcript OTTMUST00000021562 VEGA | MGI Sequence Detail 697 Not Applicable 
polypeptide OTTMUSP00000009852 VEGA | MGI Sequence Detail 130 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000879 Guanylin
Protein Ontology PR:000008347 guanylate cyclase activator 2B
References
(Earliest) J:19885 Kambouris M, et al., Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Brain Res Mol Brain Res. 1994 Sep;25(3-4):183-91
(Latest) J:192199 Makino CL, et al., Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice. PLoS One. 2012;7(10):e47637
All references(36)
Other
accession IDs
MGI:1354183, MGI:2140522

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory