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Guca2b Gene Detail
Summary
  • Symbol
    Guca2b
  • Name
    guanylate cyclase activator 2b (retina)
  • Synonyms
    Gcap2, uroguanylin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270851
    NCBI Gene: 14916
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:119656601-119658945 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 55.48 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270851
protein coding gene Chr4:119656601-119658954 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028704
protein coding gene Chr4:120857413-120859674 (-)
A/J MGP_AJ_G0028664
protein coding gene Chr4:116110690-116113991 (-)
AKR/J MGP_AKRJ_G0028617
protein coding gene Chr4:118643083-118645380 (-)
BALB/cJ MGP_BALBcJ_G0028687
protein coding gene Chr4:116739548-116741849 (-)
C3H/HeJ MGP_C3HHeJ_G0028402
protein coding gene Chr4:120199434-120202459 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029128
protein coding gene Chr4:125447332-125449628 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026405
protein coding gene Chr4:110204801-110207028 (-)
CAST/EiJ MGP_CASTEiJ_G0027833
protein coding gene Chr4:117523876-117527384 (-)
CBA/J MGP_CBAJ_G0028369
protein coding gene Chr4:128844768-128848443 (-)
DBA/2J MGP_DBA2J_G0028516
protein coding gene Chr4:116699886-116702443 (-)
FVB/NJ MGP_FVBNJ_G0028482
protein coding gene Chr4:115217521-115220385 (-)
LP/J MGP_LPJ_G0028616
protein coding gene Chr4:120982980-120986288 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028510
protein coding gene Chr4:133734195-133738590 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029165
protein coding gene Chr4:119711448-119715020 (-)
PWK/PhJ MGP_PWKPhJ_G0027556
protein coding gene Chr4:113628075-113630745 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027382
protein coding gene Chr4:116151492-116153752 (-)
WSB/EiJ MGP_WSBEiJ_G0027913
protein coding gene Chr4:119720121-119723984 (-)



Homology
more
  • Human Ortholog
    GUCA2B, guanylate cyclase activator 2B
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GUCA2B, guanylate cyclase activator 2B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GCAP-II, UGN
  • Links
    NCBI Gene ID: 2981
    neXtProt AC: NX_Q16661
    UniProt: Q16661

  • Chr Location
    1p34.2; chr1:42153421-42155824 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Guca2b
  • Find Mice (IMSR)
Homozygotes for a targeted null mutation exhibit elevated blood pressure, increased sodium levels, and reduced sodium, potassium, and fluid excretion following salt loading.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14916 NCBI Gene Model | MGI Sequence Detail 2345 C57BL/6J ±  kb
transcript NM_008191 RefSeq | MGI Sequence Detail 602 C57BL/6  
polypeptide O09051 UniProt | EBI | MGI Sequence Detail 106 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    Genomic 3
    cDNA 42

    Microarray probesets 3
Other
Accession IDs
less
MGI:1354183, MGI:2140522
References
more
  • Summaries
    All 42
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:19885 Kambouris M, et al., Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Brain Res Mol Brain Res. 1994 Sep;25(3-4):183-91
  • Latest
    J:230000 Begg DP, et al., Effect of guanylate cyclase-C activity on energy and glucose homeostasis. Diabetes. 2014 Nov;63(11):3798-804

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory