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Slc6a2
Gene Detail
 Symbol
Name
ID
Slc6a2
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
MGI:1270850
Synonyms NET, NE transporter, norepinephrine transporter, Slc6a5
Feature Type protein coding gene
Genetic Map
Chromosome 8
44.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:92961047-93001667 bp, + strand
From NCBI annotation of GRCm38

  40621 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:816  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Slc6a2

Human
homologs
Human Homolog SLC6A2, solute carrier family 6 (neurotransmitter transporter), member 2
NCBI Gene ID 6530
neXtProt AC  NX_P23975
Human Synonyms  NAT1, NET, NET1, SLC6A5
Human Chr (Location)  16q12.2; chr16:55655630-55706192 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC6A2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Norepinephrine homeostasis is abnormal in homozygous mutant mice. In addition to displaying altered behavior, mutant mice are hypersensitive to psychostimulants.
 
Interactions
Slc6a2 interacts with 372 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process monoamine transport, neurotransmitter transport, ...
Component cell surface, integral component of membrane, ...
Function alpha-tubulin binding, beta-tubulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (75)    Tissues (34)    Images (18)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 75
cDNA source data(27)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(2) cDNA(27) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000055368 (Evidence)
Entrez Gene20538 (Evidence)
UniGene57040
DFCITC1586394, TC1602205, TC1637473
DoTSDT.102556293, DT.55187830
NIA Mouse Gene IndexU042920
Consensus CDS ProjectCCDS22525.1
International Mouse Knockout Project StatusSlc6a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20538 NCBI Gene Model | MGI Sequence Detail 40621 C57BL/6J ±  kb
transcript NM_009209 RefSeq | MGI Sequence Detail 6073 C57BL/6 
polypeptide O55192 UniProt | EBI | MGI Sequence Detail 617 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(605 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000175 Sodium:neurotransmitter symporter
InterPro IPR002435 Sodium:neurotransmitter symporter, noradrenaline
Protein Ontology PR:000015186 sodium-dependent noradrenaline transporter
Graphical View of Protein Domain Structure
References (Earliest) J:47687 Fritz JD, et al., Cloning and chromosomal mapping of the murine norepinephrine transporter. J Neurochem. 1998 Jun;70(6):2241-51
(Latest) J:204914 Ma Y, et al., Extracellular norepinephrine clearance by the norepinephrine transporter is required for skeletal homeostasis. J Biol Chem. 2013 Oct 18;288(42):30105-13
All references(61)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory