Slc6a2
Gene Detail

Symbol Name ID

Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 MGI:1270850

Synonyms

NET, NE transporter, norepinephrine transporter, Slc6a5

Feature Type

protein coding gene

Genetic Map

Chromosome 8

44.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:92961047-93001667 bp, + strand From NCBI annotation of GRCm38   40621 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:816  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc6a2

Human homologs

Human Homolog		SLC6A2, solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
NCBI Gene ID		6530
neXtProt AC		NX_P23975
Human Synonyms		NAT1, NET, NET1, SLC6A5
Human Chr (Location)		16q12.2; chr16:55689542-55740104 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC6A2

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Norepinephrine homeostasis is abnormal in homozygous mutant mice. In addition to displaying altered behavior, mutant mice are hypersensitive to psychostimulants.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	monoamine transport, neurotransmitter transport, ...
Component	cell surface, integral to membrane, ...
Function	alpha-tubulin binding, beta-tubulin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (53)    Tissues (12)    Images (17)
Theiler Stages: 23

Assay Type	Results
RNA in situ	53

cDNA source data(27)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(2) cDNA(27) Primer pair(1)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000055368 (Evidence)
Entrez Gene	20538 (Evidence)
UniGene	57040
DFCI	TC1586394, TC1602205, TC1637473
DoTS	DT.102556293, DT.55187830
NIA Mouse Gene Index	U042920
Consensus CDS Project	CCDS22525.1
International Mouse Knockout Project Status	Slc6a2

Sequences

Length	Strain/Species
genomic	20538	NCBI Gene Model | MGI Sequence Detail	40621	C57BL/6J
transcript	NM_009209	RefSeq | MGI Sequence Detail	6073	C57BL/6
polypeptide	O55192	UniProt | EBI | MGI Sequence Detail	617	Not Applicable

All sequences(31) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(326 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000175	Sodium:neurotransmitter symporter
InterPro	IPR002435	Sodium:neurotransmitter symporter, noradrenaline
Protein Ontology	PR:000015186	sodium-dependent noradrenaline transporter

Graphical View of Protein Domain Structure

References

(Earliest) J:47687 Fritz JD, et al., Cloning and chromosomal mapping of the murine norepinephrine transporter. J Neurochem. 1998 Jun;70(6):2241-51
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(53)