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Slc6a2 Gene Detail
Summary
  • Symbol
    Slc6a2
  • Name
    solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • Synonyms
    NET, NE transporter, norepinephrine transporter, Slc6a5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270850
    NCBI Gene: 20538
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:93687100-93728295 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 44.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    611 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270850
protein coding gene Chr8:93686707-93728295 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033939
protein coding gene Chr8:94281813-94326532 (+)
A/J MGP_AJ_G0033922
protein coding gene Chr8:90563876-90606593 (+)
AKR/J MGP_AKRJ_G0033848
protein coding gene Chr8:93114479-93156016 (+)
BALB/cJ MGP_BALBcJ_G0033914
protein coding gene Chr8:90720745-90764223 (+)
C3H/HeJ MGP_C3HHeJ_G0033624
protein coding gene Chr8:93827981-93870162 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034435
protein coding gene Chr8:97748195-97792355 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031376
protein coding gene Chr8:84492611-84534292 (+)
CAST/EiJ MGP_CASTEiJ_G0032956
protein coding gene Chr8:93386311-93427839 (+)
CBA/J MGP_CBAJ_G0033600
protein coding gene Chr8:101000582-101045498 (+)
DBA/2J MGP_DBA2J_G0033754
protein coding gene Chr8:90108122-90150199 (+)
FVB/NJ MGP_FVBNJ_G0033701
protein coding gene Chr8:89046864-89088658 (+)
LP/J MGP_LPJ_G0033846
protein coding gene Chr8:94403222-94445771 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033743
protein coding gene Chr8:103353996-103398823 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034453
protein coding gene Chr8:93229827-93272281 (+)
PWK/PhJ MGP_PWKPhJ_G0032658
protein coding gene Chr8:89456797-89499849 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032495
protein coding gene Chr8:92079857-92122291 (+)
WSB/EiJ MGP_WSBEiJ_G0033068
protein coding gene Chr8:93689075-93731659 (+)



Homology
more
  • Human Ortholog
    SLC6A2, solute carrier family 6 member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC6A2, solute carrier family 6 member 2
  • Synonyms
    NAT1, NET, NET1, SLC6A5
  • Links
    NCBI Gene ID: 6530
    neXtProt AC: NX_P23975
    UniProt: P23975

  • Chr Location
    16q12.2; chr16:55655988-55707645 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Slc6a2 mouse models; 2 with human SLC6A2 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 4 alleles in 6 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Norepinephrine homeostasis is abnormal in homozygous mutant mice. In addition to displaying altered behavior, mutant mice are hypersensitive to psychostimulants.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20538 NCBI Gene Model | MGI Sequence Detail 41196 C57BL/6J ±  kb
    transcript NM_009209 RefSeq | MGI Sequence Detail 6073 ZRU/MplStud  
    polypeptide O55192 UniProt | EBI | MGI Sequence Detail 617 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000015186 sodium-dependent noradrenaline transporter
    • InterPro Domains
      IPR000175 Sodium:neurotransmitter symporter
      IPR002435 Sodium:neurotransmitter symporter, noradrenaline
      IPR037272 Sodium:neurotransmitter symporter superfamily
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 2
      cDNA 28
      Primer pair 3

      Microarray probesets 7
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 10
      Phenotypes 40
    • Earliest
      J:49073 Ramachandran B, et al., Differential expression of transporters for norepinephrine and glutamate in wild type, variant, and WNT1-expressing PC12 cells. J Biol Chem. 1993 Nov 15;268(32):23891-7
    • Latest
      J:343072 Vermeiren S, et al., Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia. iScience. 2023 Dec 15;26(12):108364

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory