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Slc6a2 Gene Detail
Summary
  • Symbol
    Slc6a2
  • Name
    solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • Synonyms
    NET, NE transporter, norepinephrine transporter, Slc6a5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270850
    NCBI Gene: 20538
  • Gene Overview
    MyGene.info: SLC6A2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:92960079-93001667 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41589 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 44.99 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC6A2, solute carrier family 6 member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC6A2, solute carrier family 6 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NAT1, NET, NET1, SLC6A5
  • Links
    NCBI Gene ID: 6530
    neXtProt AC: NX_P23975
    UniProt: P23975

  • Chr Location
    16q12.2; chr16:55655604-55706192 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 816
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SLC6A2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Slc6a2 mouse models; 1 with human SLC6A2 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 4 alleles in 6 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Norepinephrine homeostasis is abnormal in homozygous mutant mice. In addition to displaying altered behavior, mutant mice are hypersensitive to psychostimulants.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000061538 VEGA Gene Model | MGI Sequence Detail 41589 C57BL/6J ±  kb
    transcript OTTMUST00000150119 VEGA | MGI Sequence Detail 6007 Not Applicable  
    polypeptide OTTMUSP00000077826 VEGA | MGI Sequence Detail 617 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      626 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000015186 sodium-dependent noradrenaline transporter
    • InterPro Domains
      IPR000175 Sodium:neurotransmitter symporter
      IPR002435 Sodium:neurotransmitter symporter, noradrenaline
      IPR037272 Sodium:neurotransmitter symporter superfamily
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 2
      cDNA 28
      Primer pair 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 9
      Phenotypes 30
    • Earliest
      J:49073 Ramachandran B, et al., Differential expression of transporters for norepinephrine and glutamate in wild type, variant, and WNT1-expressing PC12 cells. J Biol Chem. 1993 Nov 15;268(32):23891-7
    • Latest
      J:254802 Pirzgalska RM, et al., Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine. Nat Med. 2017 Nov;23(11):1309-1318

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory