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Rps6kb1
Gene Detail
Symbol

Name
ID
Rps6kb1
ribosomal protein S6 kinase, polypeptide 1
MGI:1270849
Synonyms
2610318I15Rik, p70/85s6k, p70s6k, S6K1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
51.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:86498871-86544805 bp, - strand
From VEGA annotation of GRCm38

  45935 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81703  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ribosomal protein S6 kinase
Gene Tree: Rps6kb1

Human
homologs
Human Homolog RPS6KB1, ribosomal protein S6 kinase, 70kDa, polypeptide 1
NCBI Gene ID 6198
neXtProt AC  NX_P23443
Human Synonyms  p70-alpha, p70-S6K, p70 S6KA, p70(S6K)-alpha, PS6K, S6K, S6K1, S6K-beta-1, STK14A
Human Chr (Location)  17q23.1; chr17:59893046-59950426 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(34) Targeted(4)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit reduced prenatal growth, glucose intolerance, and hypoinsulinemia associated with diminished pancreatic beta cell size.
 
Interactions
Rps6kb1 interacts with 446 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process apoptotic process, cell cycle, ...
Component cell junction, cell surface, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (67)    Tissues (29)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 42
Western blot 16
RT-PCR 4
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(1) cDNA(27) Primer pair(1)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000001198 (Evidence)
Ensembl Gene ModelENSMUSG00000020516 (Evidence)
Entrez Gene72508 (Evidence)
DFCITC1595866, TC1695596, TC1576744, TC1589384
NIA Mouse Gene IndexU108184, U033223
EC2.7.11.1
Consensus CDS ProjectCCDS25201.1, CCDS48875.1
International Mouse Knockout Project StatusRps6kb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001198 VEGA Gene Model | MGI Sequence Detail 45935 C57BL/6J ±  kb
transcript OTTMUST00000002379 VEGA | MGI Sequence Detail 5531 Not Applicable 
polypeptide OTTMUSP00000001172 VEGA | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(14) UniProt(11)
Polymorphisms
SNPs within 2kb(126 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR016238 Ribosomal protein S6 kinase
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000000123 ribosomal protein S6 kinase beta-1
References
(Earliest) J:30159 Cheatham L, et al., Structural and functional analysis of pp70S6k. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11696-700
(Latest) J:213126 O'Donovan KJ, et al., B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med. 2014 May 5;211(5):801-14
All references(114)
Other
accession IDs
MGI:1919758, MGI:2144050, MGI:2144103, MGI:2144107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory