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Rps6kb1 Gene Detail
Summary
  • Symbol
    Rps6kb1
  • Name
    ribosomal protein S6 kinase, polypeptide 1
  • Synonyms
    2610318I15Rik, p70/85s6k, p70s6k, p70S6K1, S6K1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270849
    NCBI Gene: 72508
  • Gene Overview
    MyGene.info: RPS6KB1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:86498871-86544805 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45935 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.82 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RPS6KB1, ribosomal protein S6 kinase B1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RPS6KB1, ribosomal protein S6 kinase B1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p70-alpha, p70-S6K, p70 S6KA, p70(S6K)-alpha, PS6K, S6K, S6K1, S6K-beta-1, STK14A
  • Links
    NCBI Gene ID: 6198
    neXtProt AC: NX_P23443
    UniProt: P23443

  • Chr Location
    17q23.1; chr17:59893046-59950426 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 4 genetic backgrounds
    34 phenotypes from multigenic genotypes
    1 images
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced prenatal growth, glucose intolerance, and hypoinsulinemia associated with diminished pancreatic beta cell size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000001198 VEGA Gene Model | MGI Sequence Detail 45935 C57BL/6J ±  kb
    transcript OTTMUST00000002379 VEGA | MGI Sequence Detail 5531 Not Applicable  
    polypeptide OTTMUSP00000001172 VEGA | MGI Sequence Detail 525 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      123 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 28
      Primer pair 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1919758, MGI:2144050, MGI:2144103, MGI:2144107
    References
    more
    • Summaries
      All 188
      Developmental Gene Expression 37
      Gene Ontology 14
      Phenotypes 62
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:263684 Nie X, et al., mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development. PLoS Genet. 2018 Jul;14(7):e1007491

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory