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Cideb
Gene Detail
Symbol

Name
ID
Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
MGI:1270844
Synonyms
1110030C18Rik, CIDE-B, DFFA-like B
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:55754045-55758458 bp, - strand
From VEGA annotation of GRCm38

  4414 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7666  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 western clawed frog; 1 zebrafish

Gene Tree: Cideb

Human
homologs
Human Homolog CIDEB, cell death-inducing DFFA-like effector b
NCBI Gene ID 27141
neXtProt AC  NX_Q9UHD4
Human Chr (Location)  14q12; chr14:24305187-24311377 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele display a lean phenotype, increased energy expenditure and improved insulin sensitivity and are resistant to high-fat diet-induced obesity, hyperlipidemia, or liver steatosis.
 
Interactions
Cideb interacts with 46 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process apoptotic process, execution phase of apoptosis, ...
Component cytosol, intracellular, ...
Function identical protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (92)    Tissues (88)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 92
cDNA source data(73)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(73) cDNA(73)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027852 (Evidence)
Ensembl Gene ModelENSMUSG00000022219 (Evidence)
Entrez Gene12684 (Evidence)
UniGene466766
DFCITC1763602, TC1579586
DoTSDT.91444238, DT.94352577, DT.491945
NIA Mouse Gene IndexU035589
Consensus CDS ProjectCCDS27127.1
International Mouse Knockout Project StatusCideb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027852 VEGA Gene Model | MGI Sequence Detail 4414 C57BL/6J ±  kb
transcript OTTMUST00000068961 VEGA | MGI Sequence Detail 1217 Not Applicable 
polypeptide OTTMUSP00000034968 VEGA | MGI Sequence Detail 219 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(3) UniProt(3)
Polymorphisms
SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003508 Caspase-activated nuclease CIDE-N
Protein Ontology PR:000005493 cell death activator CIDE-B
References
(Earliest) J:47647 Inohara N, et al., CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 1998 May 1;17(9):2526-33
(Latest) J:213153 Harms MJ, et al., Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 2014 Apr 1;19(4):593-604
All references(42)
Other
accession IDs
MGI:1915915, MGI:2145691

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory