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Cideb Gene Detail
Summary
  • Symbol
    Cideb
  • Name
    cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
  • Synonyms
    1110030C18Rik, CIDE-B, DFFA-like B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270844
    NCBI Gene: 12684
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:55754045-55758458 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4414 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CIDEB, cell death-inducing DFFA-like effector b
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CIDEB, cell death-inducing DFFA-like effector b
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 27141
    neXtProt AC: NX_Q9UHD4
    UniProt: Q9UHD4

  • Chr Location
    14q12; chr14:24305187-24311377 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display a lean phenotype, increased energy expenditure and improved insulin sensitivity and are resistant to high-fat diet-induced obesity, hyperlipidemia, or liver steatosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000027852 VEGA Gene Model | MGI Sequence Detail 4414 C57BL/6J ±  kb
    transcript OTTMUST00000068961 VEGA | MGI Sequence Detail 1217 Not Applicable  
    polypeptide OTTMUSP00000034968 VEGA | MGI Sequence Detail 219 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      32 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 73

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915915, MGI:2145691
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:47647 Inohara N, et al., CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 1998 May 1;17(9):2526-33
    • Latest
      J:215005 Zhang LJ, et al., Cideb facilitates the lipidation of chylomicrons in the small intestine. J Lipid Res. 2014 May 15;55(7):1279-1287

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory