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Pde6d Gene Detail
Summary
  • Symbol
    Pde6d
  • Name
    phosphodiesterase 6D, cGMP-specific, rod, delta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270843
    NCBI Gene: 18582
  • Gene Overview
    MyGene.info: PDE6D
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:86542994-86582629 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 43.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    191 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270843
protein coding gene Chr1:86542994-86582808 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016250
protein coding gene Chr1:87827273-87873095 (-)
A/J MGP_AJ_G0016231
protein coding gene Chr1:84562469-84601943 (-)
AKR/J MGP_AKRJ_G0016192
protein coding gene Chr1:87041039-87080522 (-)
BALB/cJ MGP_BALBcJ_G0016188
protein coding gene Chr1:84677009-84717505 (-)
C3H/HeJ MGP_C3HHeJ_G0016016
protein coding gene Chr1:87281306-87323315 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016644
protein coding gene Chr1:91165580-91206070 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014366
protein coding gene Chr1:79043051-79085321 (-)
CAST/EiJ MGP_CASTEiJ_G0015601
protein coding gene Chr1:86511444-86554966 (-)
CBA/J MGP_CBAJ_G0015992
protein coding gene Chr1:94001087-94048271 (-)
DBA/2J MGP_DBA2J_G0016095
protein coding gene Chr1:83871291-83911144 (-)
FVB/NJ MGP_FVBNJ_G0016094
protein coding gene Chr1:82924391-82965497 (-)
LP/J MGP_LPJ_G0016166
protein coding gene Chr1:88921060-88962687 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016120
protein coding gene Chr1:97253522-97296944 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016687
protein coding gene Chr1:87159773-87203694 (-)
PWK/PhJ MGP_PWKPhJ_G0015388
protein coding gene Chr1:83155575-83196689 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015168
protein coding gene Chr1:86109248-86148698 (-)
WSB/EiJ MGP_WSBEiJ_G0015665
protein coding gene Chr1:86804260-86845374 (-)



Homology
more
  • Human Ortholog
    PDE6D, phosphodiesterase 6D
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDE6D, phosphodiesterase 6D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JBTS22, PDED
  • Links
    NCBI Gene ID: 5147
    neXtProt AC: NX_O43924
    UniProt: O43924

  • Chr Location
    2q37.1; chr2:231732425-231781327 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PDE6D associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit progressive retinal degeneration with progressive loss of rod and cone neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026239 Ensembl Gene Model | MGI Sequence Detail 39636 C57BL/6J ±  kb
    transcript ENSMUST00000027444 Ensembl | MGI Sequence Detail 1159 Not Applicable  
    polypeptide ENSMUSP00000027444 Ensembl | MGI Sequence Detail 150 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000012481 retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
    • PDB
    • InterPro Domains
      IPR008015 GMP phosphodiesterase, delta subunit
      IPR037036 GMP phosphodiesterase, delta subunit superfamily
      IPR014756 Immunoglobulin E-set
      IPR017287 Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 4
      cDNA 83
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138333
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:236897 Fansa EK, et al., PDE6delta-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity. Nat Commun. 2016 Apr 11;7:11366

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory