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Cacybp Gene Detail
Summary
  • Symbol
    Cacybp
  • Name
    calcyclin binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270839
    NCBI Gene: 12301
  • Gene Overview
    MyGene.info: CACYBP
Location & Maps
more
  • Sequence Map
    Chr1:160202367-160212875 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10509 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 69.61 cM, cytoband H1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CACYBP, calcyclin binding protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CACYBP, calcyclin binding protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GIG5, PNAS-107, S100A6BP, SIP
  • Links
    NCBI Gene ID: 27101
    neXtProt AC: NX_Q9HB71

  • Chr Location
    1q24-q25; chr1:174999435-175012027 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7649
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CACYBP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    162
  • Chemically induced (other)
    2
  • Gene trapped
    155
  • Targeted
    5
  • Genomic Mutations
    2 involving Cacybp
Mice homozygous for a null allele exhibit reduced thymus and spleen cellularity, and defects in TCR-rearrangement.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050680 VEGA Gene Model | MGI Sequence Detail 10509 C57BL/6J ±  kb
transcript OTTMUST00000128481 VEGA | MGI Sequence Detail 2098 Not Applicable  
polypeptide OTTMUSP00000069117 VEGA | MGI Sequence Detail 229 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    86 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 114
    cDNA 114

    Microarray probesets 3
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:47153 Filipek A, et al., Molecular cloning and expression of a mouse brain cDNA encoding a novel protein target of calcyclin. J Neurochem. 1998 May;70(5):1793-8
  • Latest
    J:220406 Ishihara K, et al., Comparative proteomic profiling reveals aberrant cell proliferation in the brain of embryonic Ts1Cje, a mouse model of Down syndrome. Neuroscience. 2014 Sep 28;281C:1-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory