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Nkx2-9 Gene Detail
Summary
  • Symbol
    Nkx2-9
  • Name
    NK2 homeobox 9
  • Synonyms
    Nkx-2.9, Nkx2.9, tinman
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270158
    NCBI Gene: 18094
Location & Maps
more
  • Sequence Map
    Chr12:56611389-56613284 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1896 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 24.47 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NKX2-8, NK2 homeobox 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NKX2-8, NK2 homeobox 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NKX2.8, Nkx2-9, NKX2H
  • Links
    NCBI Gene ID: 26257
    neXtProt AC: NX_O15522

  • Chr Location
    14q13.3; chr14:36580011-36582581 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7444
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NKX2-8
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Nkx2-9
  • Incidental Mutations
Mutant mice lacking both functional copies of the gene are viable and fertile but display abnormal development of the spinal accessory nerve. Another mutant exhibits progressive bronchial dysplasia leading to lung cancer in aged mutants.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023061 VEGA Gene Model | MGI Sequence Detail 1896 C57BL/6J ±  kb
transcript OTTMUST00000055589 VEGA | MGI Sequence Detail 1264 Not Applicable  
polypeptide OTTMUSP00000026635 VEGA | MGI Sequence Detail 235 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    74 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 13
    Genomic 2
    cDNA 8
    Primer pair 2
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 44
    Developmental Gene Expression 23
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:44018 Yoshiura KI, et al., Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia. Genomics. 1997 Oct 15;45(2):425-8
  • Latest
    J:235102 Jarrar W, et al., Nkx2.2 and Nkx2.9 are the key regulators to determine cell fate of branchial and visceral motor neurons in caudal hindbrain. PLoS One. 2015;10(4):e0124408

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory