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Fam3b Gene Detail
Summary
  • Symbol
    Fam3b
  • Name
    family with sequence similarity 3, member B
  • Synonyms
    9030624C24Rik, D16Jhu19e, ORF9, Pander
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270150
    NCBI Gene: 52793
  • Gene Overview
    MyGene.info: FAM3B
Location & Maps
more
  • Sequence Map
    Chr16:97471050-97504936 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33887 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 57.47 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    FAM3B, family with sequence similarity 3 member B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FAM3B, family with sequence similarity 3 member B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    2-21, C21orf11, C21orf76, ORF9, PANDER, PRED44
  • Links
    NCBI Gene ID: 54097
    neXtProt AC: NX_P58499

  • Chr Location
    21q22.3; chr21:41304223-41357727 (+)  GRCh38.p2

Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Targeted
    10
  • Genomic Mutations
    5 involving Fam3b
  • Incidental Mutations
    APF
Mice homozygous for a deletion of this gene display elevated blood glucose in glucose tolerance tests and elevated blood insulin after glucose injection, probably due to impaired insulin clearance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020067 VEGA Gene Model | MGI Sequence Detail 33887 C57BL/6J ±  kb
transcript OTTMUST00000047735 VEGA | MGI Sequence Detail 853 Not Applicable  
polypeptide OTTMUSP00000021680 VEGA | MGI Sequence Detail 235 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    173 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 5
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGI:1923006
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Diseases 3
    Gene Ontology 4
    Phenotypes 27
  • Earliest
    J:50129 Cabin DE, et al., Physical and comparative mapping of distal mouse chromosome 16. 5 p5. Genome Res. 1998 Sep;8(9):940-50
  • Latest
    J:217205 Moak SL, et al., Enhanced glucose tolerance in pancreatic-derived factor (PANDER) knockout C57BL/6 mice. Dis Model Mech. 2014 Nov;7(11):1307-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory