Cyp2j5
Gene Detail

Symbol

Name
ID

Cyp2j5
cytochrome P450, family 2, subfamily j, polypeptide 5
MGI:1270149

Feature Type

protein coding gene

Genetic Map

Chromosome 4
44.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:96628773-96664154 bp, - strand From VEGA annotation of GRCm38   35382 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:116530  Vertebrate Homology Class
1 mouse; 1 western clawed frog

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp2j5

Mutations,
alleles, and
phenotypes

All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 

Female mice homozygous for a null mutation display increased systolic blood pressure, increased left ventricular weight, decreased litter sizes, decreased serum estrogen levels, and increased induced vasoconstriction responses.

 

Interactions

Cyp2j5 interacts with 144 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (23 annotations)

Process	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure, arachidonic acid metabolic process, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	arachidonic acid epoxygenase activity, aromatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (12)    Tissues (12)    Tissue x Stage Matrix (view)

Assay Type	Results
RT-PCR	12

cDNA source data(123)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(125) cDNA(123) Primer pair(2)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000007943 (Evidence)
Ensembl Gene Model	ENSMUSG00000052520 (Evidence)
Entrez Gene	13109 (Evidence)
UniGene	12838
DFCI	TC1575665, TC1653316
DoTS	DT.532632
NIA Mouse Gene Index	U112954
EC	1.14.14.1
Consensus CDS Project	CCDS18371.1
International Mouse Knockout Project Status	Cyp2j5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007943	VEGA Gene Model | MGI Sequence Detail	35382	C57BL/6J
transcript	OTTMUST00000018013	VEGA | MGI Sequence Detail	2345	Not Applicable
polypeptide	OTTMUSP00000008270	VEGA | MGI Sequence Detail	501	Not Applicable

All sequences(28) RefSeq(4) UniProt(5)

Polymorphisms

PCR(1) : SNPs within 2kb(84 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR017972	Cytochrome P450, conserved site
InterPro	IPR002401	Cytochrome P450, E-class, group I
InterPro	IPR008071	Cytochrome P450, E-class, group I, CYP2J-like
Protein Ontology	PR:000006239	cytochrome P450 2J5

References

(Earliest) J:47555 Ma J, et al., Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4. Genomics. 1998 Apr 1;49(1):152-5
(Latest) J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
All references(28)