Cyp2j5 MGI Mouse Gene Detail - MGI:1270149 - cytochrome P450, family 2, subfamily j, polypeptide 5

Cyp2j5 Gene Detail

Symbol

Cyp2j5
Name

cytochrome P450, family 2, subfamily j, polypeptide 5

Feature Type

protein coding gene
IDs

MGI:1270149
NCBI Gene: 13109
Member of

Cyp2j cluster
Alliance

gene page

Sequence Map

Chr4:96628773-96664154 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

35382 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 44.71 cM
Mapping Data

2 experiments

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HomoloGene

Vertebrate Homology Class 116530
1 mouse;1 frog, western clawed
Protein SuperFamily

cytochrome P450 CYP2D6
Gene Tree

Cyp2j5

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

2
Radiation induced

1
Targeted

2
Genomic Mutations

4 involving Cyp2j5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available

Female mice homozygous for a null mutation display increased systolic blood pressure, increased left ventricular weight, decreased litter sizes, decreased serum estrogen levels, and increased induced vasoconstriction responses.

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All GO Annotations

17
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

12
Tissues

12
cDNA Data

123
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Cyp2j5 interacts with 144 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

22
RefSeq

4
UniProt

3
CCDS

CCDS18371.1
UniGene

12838

			Length	Strain/Species	Flank
genomic	OTTMUSG00000007943	VEGA Gene Model \| MGI Sequence Detail	35382	C57BL/6J	± kb
transcript	OTTMUST00000018013	VEGA \| MGI Sequence Detail	2345	Not Applicable
polypeptide	OTTMUSP00000008270	VEGA \| MGI Sequence Detail	501	Not Applicable

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SNPs within 2kb

77 from dbSNP Build 142

PCR

1

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UniProt

3 Sequences
Protein Ontology

PR:000006239 cytochrome P450 2J5

(term hierarchy)
EC

1.14.14.1
InterPro Domains

IPR001128 Cytochrome P450

IPR017972 Cytochrome P450, conserved site

IPR002401 Cytochrome P450, E-class, group I

IPR008071 Cytochrome P450, E-class, group I, CYP2J-like

IPR036396 Cytochrome P450 superfamily

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All nucleic 125

cDNA 123

Primer pair 2

Microarray probesets 4

Summaries

All 29

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 6
Earliest

J:47555 Ma J, et al., Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4. Genomics. 1998 Apr 1;49(1):152-5
Latest

J:223128 Zhou GL, et al., Deletion of the murine cytochrome P450 Cyp2j locus by fused BAC-mediated recombination identifies a role for Cyp2j in the pulmonary vascular response to hypoxia. PLoS Genet. 2013 Nov;9(11):e1003950

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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