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Dnaja1
Gene Detail
Symbol

Name
ID
Dnaja1
DnaJ (Hsp40) homolog, subfamily A, member 1
MGI:1270129
Synonyms
Hsj2, Nedd7
Feature Type
protein coding gene
Genetic Map
Chromosome 4
20.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:40722150-40734964 bp, + strand
From VEGA annotation of GRCm38

  12815 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55588  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: heat shock protein DnaJ
Gene Tree: Dnaja1

Human
homologs
Human Homolog DNAJA1, DnaJ (Hsp40) homolog, subfamily A, member 1
NCBI Gene ID 3301
neXtProt AC  NX_P31689
Human Synonyms  DJ-2, DjA1, hDJ-2, HDJ2, HSDJ, HSJ2, HSPF4, NEDD7
Human Chr (Location)  9p13.3; chr9:33025211-33039064 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(35) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for a knock-out allele exhibit decreased postnatal growth and reduced fertility with severe defects in late stages of spermatogenesis that involve aberrant androgen receptor signaling in Sertoli cells and disruption of Sertoli-germ cell adherens junctions.
 
Interactions
Dnaja1 interacts with 387 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process androgen receptor signaling pathway, DNA damage response, detection of DNA damage, ...
Component cytosol, extracellular vesicular exosome, ...
Function ATP binding, chaperone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (16)    Tissues (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 16
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(19) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000006566 (Evidence)
Ensembl Gene ModelENSMUSG00000028410 (Evidence)
Entrez Gene15502 (Evidence)
Consensus CDS ProjectCCDS18049.1
International Mouse Knockout Project StatusDnaja1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006566 VEGA Gene Model | MGI Sequence Detail 12815 C57BL/6J ±  kb
transcript OTTMUST00000015000 VEGA | MGI Sequence Detail 3376 Not Applicable 
polypeptide OTTMUSP00000006930 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(6) UniProt(6)
Polymorphisms
PCR(1) : SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012724 Chaperone DnaJ
InterPro IPR002939 Chaperone DnaJ, C-terminal
InterPro IPR001623 DnaJ domain
InterPro IPR018253 DnaJ domain, conserved site
InterPro IPR001305 Heat shock protein DnaJ, cysteine-rich domain
InterPro IPR008971 HSP40/DnaJ peptide-binding
Protein Ontology PR:000006570 DnaJ homolog subfamily A member 1
References
(Earliest) J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
(Latest) J:197389 Slater LH, et al., CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9932-7
All references(37)
Other
accession IDs
MGD-MRK-12813, MGI:97300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory