Ulk1
Gene Detail

Symbol Name ID

Ulk1 unc-51 like kinase 1 MGI:1270126

Synonyms

mKIAA0722, Unc51.1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

53.70 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:110784489-110810081 bp, - strand From NCBI annotation of GRCm38   25593 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2640  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serine/threonine-protein kinase, ULK1/2 types
Gene Tree: Ulk1

Human homologs

Human Homolog		ULK1, unc-51-like kinase 1 (C. elegans)
NCBI Gene ID		8408
neXtProt AC		NX_O75385
Human Synonyms		ATG1, ATG1A, hATG1, UNC51, Unc51.1
Human Chr (Location)		12q24.3; chr12:132379279-132407707 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(51) : Targeted(4) Gene trapped(47)
 

Null homozygotes have blood defects including an increase in mean corpuscular volume and the presence of red blood cells that contain mitochondria.

 

Gene Ontology (GO) classifications

All GO classifications: (56 annotations)

Process	autophagic vacuole assembly, autophagy, ...
Component	autophagic vacuole, cytoplasm, ...
Function	ATP binding, kinase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (61)    Tissues (38)    Images (21)
Theiler Stages: 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	61

cDNA source data(213)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(215) cDNA(214) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000029512 (Evidence)
Entrez Gene	22241 (Evidence)
UniGene	271898
DFCI	TC1572987, TC1591972, TC1630689
DoTS	DT.101738240, DT.101738242, DT.534092
NIA Mouse Gene Index	U026567
EC	2.7.11.1
Consensus CDS Project	CCDS19532.1
International Mouse Knockout Project Status	Ulk1

Sequences

Length	Strain/Species
genomic	22241	NCBI Gene Model | MGI Sequence Detail	25593	C57BL/6J
transcript	NM_009469	RefSeq | MGI Sequence Detail	5215	C57BL/6
polypeptide	O70405	UniProt | EBI | MGI Sequence Detail	1051	Not Applicable

All sequences(37) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(117 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR022708	Serine/threonine-protein kinase, C-terminal
InterPro	IPR016237	Serine/threonine-protein kinase, Ulk1/Ulk2
Protein Ontology	PR:000017077	serine/threonine-protein kinase ULK1

Graphical View of Protein Domain Structure

References

(Earliest) J:47612 Yan J, et al., Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Biochem Biophys Res Commun. 1998 May 8;246(1):222-7
(Latest) J:191056 Henault J, et al., Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes. Immunity. 2012 Dec 14;37(6):986-97
All references(61)

Other accession IDs

MGI:2141081