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Ulk1
Gene Detail
Symbol

Name
ID
Ulk1
unc-51 like kinase 1
MGI:1270126
Synonyms
mKIAA0722, Unc51.1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
53.70 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:110784488-110810097 bp, - strand
From Ensembl annotation of GRCm38

  25610 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2640  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: serine/threonine-protein kinase, ULK1/2 types
Gene Tree: Ulk1

Human
homologs
Human Homolog ULK1, unc-51 like autophagy activating kinase 1
NCBI Gene ID 8408
neXtProt AC  NX_O75385
Human Synonyms  ATG1, ATG1A, hATG1, UNC51, Unc51.1
Human Chr (Location)  12q24.3; chr12:131894734-131923162 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(51) : Gene trapped(47) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Null homozygotes have blood defects including an increase in mean corpuscular volume and the presence of red blood cells that contain mitochondria.
 
Interactions
Ulk1 interacts with 257 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process autophagic vacuole assembly, autophagy, ...
Component ATG1/UKL1 signaling complex, autophagic vacuole, ...
Function ATP binding, kinase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (61)    Tissues (39)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 61
cDNA source data(213)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(215) cDNA(214) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000029512 (Evidence)
Entrez Gene22241 (Evidence)
UniGene271898
DFCITC1572987, TC1591972, TC1630689
DoTSDT.534092, DT.101738240, DT.101738242
NIA Mouse Gene IndexU026567
EC2.7.11.1
Consensus CDS ProjectCCDS19532.1
International Mouse Knockout Project StatusUlk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029512 Ensembl Gene Model | MGI Sequence Detail 25610 C57BL/6J ±  kb
transcript ENSMUST00000031490 Ensembl | MGI Sequence Detail 5213 Not Applicable 
polypeptide ENSMUSP00000031490 Ensembl | MGI Sequence Detail 1051 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(6) UniProt(13)
Polymorphisms
SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR022708 Serine/threonine-protein kinase, C-terminal
InterPro IPR016237 Serine/threonine-protein kinase, Ulk1/Ulk2
Protein Ontology PR:000017077 serine/threonine-protein kinase ULK1
References
(Earliest) J:47612 Yan J, et al., Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Biochem Biophys Res Commun. 1998 May 8;246(1):222-7
(Latest) J:213953 Ro SH, et al., Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J. 2014 Sep;281(17):3816-27
All references(66)
Other
accession IDs
MGI:2141081

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory