About   Help   FAQ
Ulk1 Gene Detail
Summary
  • Symbol
    Ulk1
  • Name
    unc-51 like kinase 1
  • Synonyms
    mKIAA0722, Unc51.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270126
    NCBI Gene: 22241
  • Gene Overview
    MyGene.info: ULK1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:110784488-110810097 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.70 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    126 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270126
protein coding gene Chr5:110784488-110810121 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029893
protein coding gene Chr5:113265168-113290502 (-)
A/J MGP_AJ_G0029859
protein coding gene Chr5:108875210-108900781 (-)
AKR/J MGP_AKRJ_G0029797
protein coding gene Chr5:112324304-112349849 (-)
BALB/cJ MGP_BALBcJ_G0029870
protein coding gene Chr5:110246787-110272742 (-)
C3H/HeJ MGP_C3HHeJ_G0029590
protein coding gene Chr5:112762891-112789290 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030323
protein coding gene Chr5:117714034-117741512 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027552
protein coding gene Chr5:103710432-103736094 (-)
CAST/EiJ MGP_CASTEiJ_G0028998
protein coding gene Chr5:111635969-111661592 (-)
CBA/J MGP_CBAJ_G0029557
protein coding gene Chr5:122138769-122167548 (-)
DBA/2J MGP_DBA2J_G0029707
protein coding gene Chr5:108950872-108976439 (-)
FVB/NJ MGP_FVBNJ_G0029664
protein coding gene Chr5:107623055-107649440 (-)
LP/J MGP_LPJ_G0029795
protein coding gene Chr5:113817614-113842997 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029695
protein coding gene Chr5:126786886-126813348 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030364
protein coding gene Chr5:111773960-111799921 (-)
PWK/PhJ MGP_PWKPhJ_G0028712
protein coding gene Chr5:107532710-107558566 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028550
protein coding gene Chr5:109239963-109265573 (-)
WSB/EiJ MGP_WSBEiJ_G0029074
protein coding gene Chr5:112248162-112273730 (-)



Homology
more
  • Human Ortholog
    ULK1, unc-51 like autophagy activating kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ULK1, unc-51 like autophagy activating kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATG1, ATG1A, hATG1, UNC51, Unc51.1
  • Links
    NCBI Gene ID: 8408
    neXtProt AC: NX_O75385
    UniProt: O75385

  • Chr Location
    12q24.33; chr12:131894734-131923162 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Null homozygotes have blood defects including an increase in mean corpuscular volume and the presence of red blood cells that contain mitochondria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029512 Ensembl Gene Model | MGI Sequence Detail 25610 C57BL/6J ±  kb
    transcript ENSMUST00000200299 Ensembl | MGI Sequence Detail 3581 Not Applicable  
    polypeptide ENSMUSP00000143536 Ensembl | MGI Sequence Detail 1057 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • EC
    • InterPro Domains
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
      IPR022708 Serine/threonine-protein kinase, C-terminal
      IPR016237 Serine/threonine-protein kinase, Ulk1/Ulk2
    Molecular
    Reagents
    less
    • All nucleic 216
      cDNA 215
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141081
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 6
      Gene Ontology 21
      Phenotypes 34
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:267290 Cunha LD, et al., LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance. Cell. 2018 Oct 4;175(2):429-441.e16

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory