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Fbxo41 Gene Detail
Summary
  • Symbol
    Fbxo41
  • Name
    F-box protein 41
  • Synonyms
    D6Ertd538e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261912
    NCBI Gene: 330369
Location & Maps
more
  • Sequence Map
    Chr6:85469574-85502994 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33421 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.48 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FBXO41, F-box protein 41
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FBXO41, F-box protein 41
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBX41
  • Links
    NCBI Gene ID: 150726
    neXtProt AC: NX_Q8TF61

  • Chr Location
    2p13.2; chr2:73254682-73284453 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Fbxo41
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit postnatal lethality and premature death by 10 weeks, growth retardation, abnormal gait, dragging hindlimbs, ataxia, impaired balance, impaired coordination, tremors and abnormal neuronal migration.
Gene Ontology
(GO)
Classifications
less
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029064 VEGA Gene Model | MGI Sequence Detail 33421 C57BL/6J ±  kb
transcript OTTMUST00000072104 VEGA | MGI Sequence Detail 6505 Not Applicable  
polypeptide OTTMUSP00000037035 VEGA | MGI Sequence Detail 873 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    68 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007410 F-box only protein 41
  • InterPro Domains
    IPR001810 F-box domain
    IPR032675 Leucine-rich repeat domain, L domain-like
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 29
    Developmental Gene Expression 4
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory