Fbxo28 MGI Mouse Gene Detail - MGI:1261890

Symbol

Fbxo28
Name

F-box protein 28
Synonyms

4833428J17Rik, 5730505P19Rik, D1Ertd578e, Fbx28, mKIAA0483

Feature Type

protein coding gene
IDs

MGI:1261890
NCBI Gene: 67948
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:182140667-182169171 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 84.93 cM
Mapping Data

2 experiments

SNPs within 2kb

695 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261890	protein coding gene	Chr1:182140667-182169194 (-)
129S1/SvImJ	ENSMUSG00200022056	protein coding gene	Chr1:179901323-179929850 (-)
A/J	ENSMUSG00195039624	protein coding gene	Chr1:179493758-179521887 (-)
AKR/J	ENSMUSG00220020283	protein coding gene	Chr1:178731808-178760336 (-)
BALB/cJ	ENSMUSG00180036443	protein coding gene	Chr1:179552661-179581188 (-)
C3H/HeJ	ENSMUSG00175035711	protein coding gene	Chr1:179728358-179756885 (-)
C57BL/6NJ	ENSMUSG00215012513	protein coding gene	Chr1:178954085-178982613 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015000	protein coding gene	Chr1:172304842-172333701 (-)
CAST/EiJ	ENSTCUG00005039904	protein coding gene	Chr1:177474267-177502437 (-)
CBA/J	ENSMUSG00210018336	protein coding gene	Chr1:179371637-179400165 (-)
DBA/2J	ENSMUSG00185033918	protein coding gene	Chr1:183991051-184019579 (-)
FVB/NJ	ENSMUSG00205024377	protein coding gene	Chr1:178422247-178450776 (-)
JF1/MsJ	ENSUMUG00000004865	protein coding gene	Chr1:182995930-183025141 (-)
LP/J	ENSMUSG00230020361	protein coding gene	Chr1:183560588-183589115 (-)
NOD/ShiLtJ	ENSMUSG00190026816	protein coding gene	Chr1:179410261-179438387 (-)
NZO/HlLtJ	ENSMUSG00225010811	protein coding gene	Chr1:187302363-187330969 (-)
PWK/PhJ	ENSLUMG00010016147	protein coding gene	Chr1:178243827-178271940 (-)
SPRET/EiJ	ENSMSPG00010032146	protein coding gene	Chr1:181728351-181757300 (-)
WSB/EiJ	ENSIUOG00005010988	protein coding gene	Chr1:178593098-178621624 (-)

Human Ortholog

FBXO28, F-box protein 28

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXO28, F-box protein 28
Synonyms

CENP-30, DEE100, Fbx28
Links

HGNC:29046

NCBI Gene ID: 23219

UniProt: Q9NVF7
Chr Location

1q42.11; chr1:224114111-224162047 (+) GRCh38

MGI Vertebrate Homology

Fbxo28 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBXO28
Gene Tree

Fbxo28

Diseases

1 with human FBXO28 associations

				Human Disease	Mouse Models
				developmental and epileptic encephalopathy 100 IDs developmental and epileptic encephalopathy 100 DOID:0070386 OMIM:619777

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

7
Gene trapped

9
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

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All GO Annotations

19
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

96

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxo28

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All Sequences

57
RefSeq

2
UniProt

5
CCDS

CCDS15588.1

Ensembl

ENSMUSG00000047539 (Evidence)
NCBI Gene

67948

			Length	Strain/Species	Flank
genomic	67948	NCBI Gene Model \| MGI Sequence Detail	28505	C57BL/6J	± kb
transcript	NM_175127	RefSeq \| MGI Sequence Detail	4932	ZRU/MplStud
polypeptide	Q8BIG4	UniProt \| EBI \| MGI Sequence Detail	368	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007399 F-box only protein 28

(term hierarchy)
InterPro Domains

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR039719 F-box only protein 28

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All nucleic 97

cDNA 96

Primer pair 1

Microarray probesets 6

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MGI:1915198, MGI:1918879

Summaries

All 46

Gene Ontology 7

Phenotypes 13
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:383094 Chang H, et al., Fbxo28 is essential for spindle migration and morphology during mouse oocyte meiosis I. Int J Biol Macromol. 2024 Aug;275(Pt 1):133232

TSS for Fbxo28:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15614	Chr1:182169150-182169190 (-)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24