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Wwc2 Gene Detail
Summary
  • Symbol
    Wwc2
  • Name
    WW, C2 and coiled-coil domain containing 2
  • Synonyms
    D8Ertd594e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261872
    NCBI Gene: 52357
Location & Maps
more
  • Sequence Map
    Chr8:47823959-47990924 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      166966 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 26.91 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    WWC2, WW and C2 domain containing 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WWC2, WW and C2 domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BOMB
  • Links
    NCBI Gene ID: 80014
    neXtProt AC: NX_Q6AWC2

  • Chr Location
    4q35.1; chr4:183098635-183320777 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32618
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: WWC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Gene trapped
    19
  • Targeted
    1
  • Genomic Mutations
    1 involving Wwc2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000061832 VEGA Gene Model | MGI Sequence Detail 166966 C57BL/6J ±  kb
transcript OTTMUST00000150876 VEGA | MGI Sequence Detail 8678 Not Applicable  
polypeptide OTTMUSP00000078245 VEGA | MGI Sequence Detail 1187 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1047 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 23
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2142705, MGI:2142867
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:199301 Lavado A, et al., Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development. 2013 Aug;140(16):3323-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory