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Wwc2 Gene Detail
Summary
  • Symbol
    Wwc2
  • Name
    WW, C2 and coiled-coil domain containing 2
  • Synonyms
    D8Ertd594e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261872
    NCBI Gene: 52357
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:48279117-48443579 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 26.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4729 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261872
 protein coding gene Chr8:48276994-48443959 (-)
129S1/SvImJ ENSMUSG00200005526
 protein coding gene Chr8:43367139-43533313 (-)
A/J ENSMUSG00195003982
 protein coding gene Chr8:43895353-44062038 (-)
AKR/J ENSMUSG00220004458
 protein coding gene Chr8:43696807-43851557 (-)
BALB/cJ ENSMUSG00180002668
 protein coding gene Chr8:43436317-43602993 (-)
C3H/HeJ ENSMUSG00175004996
 protein coding gene Chr8:43557876-43724545 (-)
C57BL/6NJ ENSMUSG00215010473
 protein coding gene Chr8:43367417-43534093 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031047
 protein coding gene Chr8:41417613-41584407 (-)
CAST/EiJ ENSTCUG00005019297
 protein coding gene Chr8:43384900-43550808 (-)
CBA/J ENSMUSG00210018616
 protein coding gene Chr8:43435398-43602162 (-)
DBA/2J ENSMUSG00185005545
 protein coding gene Chr8:49321862-49488526 (-)
FVB/NJ ENSMUSG00205002577
 protein coding gene Chr8:42565091-42731893 (-)
JF1/MsJ ENSUMUG00000005155
 protein coding gene Chr8:50930267-51091547 (-)
LP/J ENSMUSG00230016072
 protein coding gene Chr8:52974148-53140919 (-)
NOD/ShiLtJ ENSMUSG00190005863
 protein coding gene Chr8:43473474-43640142 (-)
NZO/HlLtJ ENSMUSG00225011481
 protein coding gene Chr8:56562795-56729561 (-)
PWK/PhJ ENSLUMG00010009069
 protein coding gene Chr8:43212599-43375753 (-)
SPRET/EiJ ENSMSPG00010005595
 protein coding gene Chr8:44090545-44256246 (-)
WSB/EiJ ENSIUOG00005002517
 protein coding gene Chr8:44296794-44459556 (-)



Homology
more
  • Human Ortholog
    WWC2, WW and C2 domain containing 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WWC2, WW and C2 domain containing 2
  • Synonyms
    BOMB
  • Links
    NCBI Gene ID: 80014
    UniProt: Q6AWC2

  • Chr Location
    4q35.1; chr4:183099126-183320777 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    1
  • cDNA Data
    25
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 52357 NCBI Gene Model | MGI Sequence Detail 164463 C57BL/6J ±  kb
    transcript NM_133791 RefSeq | MGI Sequence Detail 6548 ZRU/MplStud  
    polypeptide Q6NXJ0 UniProt | EBI | MGI Sequence Detail 1187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 25
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2142705, MGI:2142867
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:361134 Wang X, et al., WWC proteins-mediated compensatory mechanism restricts schwannomatosis driven by NF2 loss of function. Sci Adv. 2025 Jan 24;11(4):eadp4765
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory