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Ankle2 Gene Detail
Summary
  • Symbol
    Ankle2
  • Name
    ankyrin repeat and LEM domain containing 2
  • Synonyms
    1110001J12Rik, D5Ertd585e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261856
    NCBI Gene: 71782
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:110231004-110256651 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.40 cM, cytoband F
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    222 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261856
protein coding gene Chr5:110231004-110256651 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029882
protein coding gene Chr5:112673265-112701012 (+)
A/J MGP_AJ_G0029847
protein coding gene Chr5:108308187-108336470 (+)
AKR/J MGP_AKRJ_G0029785
protein coding gene Chr5:111758757-111785300 (+)
BALB/cJ MGP_BALBcJ_G0029858
protein coding gene Chr5:109678978-109704819 (+)
C3H/HeJ MGP_C3HHeJ_G0029578
protein coding gene Chr5:112185557-112211192 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030311
protein coding gene Chr5:117120038-117146801 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027540
protein coding gene Chr5:103137115-103162132 (+)
CAST/EiJ MGP_CASTEiJ_G0028986
protein coding gene Chr5:111046319-111070551 (+)
CBA/J MGP_CBAJ_G0029545
protein coding gene Chr5:121524416-121550043 (+)
DBA/2J MGP_DBA2J_G0029695
protein coding gene Chr5:108374898-108400901 (+)
FVB/NJ MGP_FVBNJ_G0029652
protein coding gene Chr5:107050711-107076819 (+)
LP/J MGP_LPJ_G0029783
protein coding gene Chr5:113234690-113261665 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029683
protein coding gene Chr5:126169581-126196213 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030352
protein coding gene Chr5:111191498-111217238 (+)
PWK/PhJ MGP_PWKPhJ_G0028700
protein coding gene Chr5:106964468-106990851 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028538
protein coding gene Chr5:108656869-108685875 (+)
WSB/EiJ MGP_WSBEiJ_G0029062
protein coding gene Chr5:111643248-111673319 (+)



Homology
more
  • Human Ortholog
    ANKLE2, ankyrin repeat and LEM domain containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANKLE2, ankyrin repeat and LEM domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA0692, Lem4, LEMD7, MCPH16
  • Links
    NCBI Gene ID: 23141
    neXtProt AC: NX_Q86XL3
    UniProt: Q86XL3

  • Chr Location
    12q24.33; chr12:132725667-132761888 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 35424
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANKLE2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ANKLE2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 71782 NCBI Gene Model | MGI Sequence Detail 25648 C57BL/6J ±  kb
transcript NM_001253814 RefSeq | MGI Sequence Detail 5259 C57BL/6  
polypeptide Q6P1H6 UniProt | EBI | MGI Sequence Detail 964 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000031037 ankyrin repeat and LEM domain-containing protein 2
  • InterPro Domains
    IPR035007 Ankyrin repeat and LEM domain-containing protein 2
    IPR035006 Ankyrin repeat and LEM domain-containing protein 2, LEM domain
    IPR020683 Ankyrin repeat-containing domain
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR003887 LEM domain
    IPR011015 LEM/LEM-like domain superfamily
Molecular
Reagents
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  • All nucleic 114
    Genomic 1
    cDNA 112
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1919032, MGI:2140951
References
more
  • Summaries
    All 41
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:214793 Han BY, et al., Zinc finger protein Zfp335 is required for the formation of the naive T cell compartment. Elife. 2014;3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory