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Cisd1 Gene Detail
Summary
  • Symbol
    Cisd1
  • Name
    CDGSH iron sulfur domain 1
  • Synonyms
    D10Ertd214e, mitoNEET, Zcd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261855
    NCBI Gene: 52637
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:71330494-71344849 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 36.88 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261855
protein coding gene Chr10:71330480-71344954 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017344
protein coding gene Chr10:71323371-71339282 (-)
A/J MGP_AJ_G0017321
protein coding gene Chr10:68868454-68883274 (-)
AKR/J MGP_AKRJ_G0017282
protein coding gene Chr10:70758929-70778193 (-)
BALB/cJ MGP_BALBcJ_G0017281
protein coding gene Chr10:69070027-69085027 (-)
C3H/HeJ MGP_C3HHeJ_G0017105
protein coding gene Chr10:70762884-70777770 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017739
protein coding gene Chr10:73858048-73874276 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015429
protein coding gene Chr10:65439237-65453771 (-)
CAST/EiJ MGP_CASTEiJ_G0016675
protein coding gene Chr10:70922858-70938227 (-)
CBA/J MGP_CBAJ_G0017077
protein coding gene Chr10:76740644-76755231 (-)
DBA/2J MGP_DBA2J_G0017182
protein coding gene Chr10:68224779-68239290 (-)
FVB/NJ MGP_FVBNJ_G0017175
protein coding gene Chr10:67393399-67409085 (-)
LP/J MGP_LPJ_G0017255
protein coding gene Chr10:71759807-71774266 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017203
protein coding gene Chr10:78808039-78822996 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017778
protein coding gene Chr10:70719260-70733882 (-)
PWK/PhJ MGP_PWKPhJ_G0016459
protein coding gene Chr10:68079929-68095893 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016242
protein coding gene Chr10:70089424-70103961 (-)
WSB/EiJ MGP_WSBEiJ_G0016739
protein coding gene Chr10:70674426-70689217 (-)



Homology
more
  • Human Ortholog
    CISD1, CDGSH iron sulfur domain 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CISD1, CDGSH iron sulfur domain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C10orf70, MDS029, mitoNEET, ZCD1
  • Links
    NCBI Gene ID: 55847
    neXtProt AC: NX_Q9NZ45
    UniProt: Q9NZ45

  • Chr Location
    10q21.1; chr10:58269102-58290553 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10212
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CISD1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    26
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Cisd1
  • Find Mice (IMSR)
Mice homozygous for a null allele exhibit reduced oxidative capacity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 52637 NCBI Gene Model | MGI Sequence Detail 14356 C57BL/6J ±  kb
transcript NM_134007 RefSeq | MGI Sequence Detail 965 C57BL/6  
polypeptide Q91WS0 UniProt | EBI | MGI Sequence Detail 108 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005501 CDGSH iron-sulfur domain-containing protein 1
  • InterPro Domains
    IPR018967 Iron sulphur-containing domain, CDGSH-type
    IPR019610 Iron sulphur domain-containing, mitoNEET, N-terminal
Molecular
Reagents
less
  • All nucleic 125
    cDNA 123
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGI:2143766, MGI:2144588
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:237286 Hu X, et al., MitoNEET Deficiency Alleviates Experimental Alcoholic Steatohepatitis in Mice by Stimulating Endocrine Adiponectin-Fgf15 Axis. J Biol Chem. 2016 Oct 21;291(43):22482-22495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory