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Esyt2 Gene Detail
Summary
  • Symbol
    Esyt2
  • Name
    extended synaptotagmin-like protein 2
  • Synonyms
    2410017M09Rik, 4921504I16Rik, D12Ertd551e, Fam62b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261845
    NCBI Gene: 52635
  • Gene Overview
    MyGene.info: ESYT2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:116281196-116391050 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      109855 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 62.65 cM, cytoband F2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ESYT2, extended synaptotagmin 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ESYT2, extended synaptotagmin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHR2SYT, E-Syt2, FAM62B
  • Links
    NCBI Gene ID: 57488
    neXtProt AC: NX_A0FGR8
    UniProt: A0FGR8

  • Chr Location
    7q36.3; chr7:158730998-158829628 (-)  GRCh38.p7

Human Diseases
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  • References
    16 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    242 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice are viable and fertile without overt morphological defects except reduced FGF-stimulated mouse embryonic fibroblast migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021171 Ensembl Gene Model | MGI Sequence Detail 109855 C57BL/6J ±  kb
    transcript ENSMUST00000100986 Ensembl | MGI Sequence Detail 5560 Not Applicable  
    polypeptide ENSMUSP00000098548 Ensembl | MGI Sequence Detail 845 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1104 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR037733 Extended synaptotagmin, C2A domain
      IPR037749 Extended synaptotagmin, C2B domain
      IPR037752 Extended synaptotagmin, C-terminal C2 domain
      IPR031468 Synaptotagmin-like mitochondrial-lipid-binding domain
    Molecular
    Reagents
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    • All nucleic 148
      cDNA 146
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1919208, MGI:1921297
    References
    more
    • Summaries
      All 268
      Developmental Gene Expression 3
      Diseases 16
      Gene Ontology 4
      Phenotypes 242
    • Earliest
      J:37107 Mayford M, et al., Control of memory formation through regulated expression of a CaMKII transgene. Science. 1996 Dec 6;274(5293):1678-83
    • Latest
      J:261165 Wang X, et al., Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy. PLoS One. 2018;13(4):e0195486

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory