Vps37a MGI Mouse Gene Detail - MGI:1261835 - vacuolar protein sorting 37A

Symbol

Vps37a
Name

vacuolar protein sorting 37A
Synonyms

2210018P21Rik, 4930592A21Rik, D8Ertd531e

Feature Type

protein coding gene
IDs

MGI:1261835
NCBI Gene: 52348
Alliance

genome feature page
Transcription Start Sites

11 TSS

Sequence Map

Chr8:40964824-41003798 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 23.89 cM, cytoband B1.2
Mapping Data

4 experiments

SNPs within 2kb

953 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261835	protein coding gene	Chr8:40964482-41004175 (+)
129S1/SvImJ	ENSMUSG00200007583	protein coding gene	Chr8:36037060-36085120 (+)
A/J	ENSMUSG00195005687	protein coding gene	Chr8:36511963-36560025 (+)
AKR/J	ENSMUSG00220005741	protein coding gene	Chr8:36319580-36367633 (+)
BALB/cJ	ENSMUSG00180003128	protein coding gene	Chr8:36056762-36104824 (+)
C3H/HeJ	ENSMUSG00175014613	protein coding gene	Chr8:36231536-36279593 (+)
C57BL/6NJ	ENSMUSG00215007234	protein coding gene	Chr8:36036583-36092127 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030995	protein coding gene	Chr8:34461531-34501399 (+)
CAST/EiJ	ENSTCUG00005005391	protein coding gene	Chr8:36164464-36212035 (+)
CBA/J	ENSMUSG00210012690	protein coding gene	Chr8:36074965-36123022 (+)
DBA/2J	ENSMUSG00185005507	protein coding gene	Chr8:41975460-42023521 (+)
FVB/NJ	ENSMUSG00205002233	protein coding gene	Chr8:35238925-35286988 (+)
JF1/MsJ	ENSUMUG00000008995	protein coding gene	Chr8:43697347-43744553 (+)
LP/J	ENSMUSG00230009109	protein coding gene	Chr8:45625257-45673318 (+)
NOD/ShiLtJ	ENSMUSG00190015170	protein coding gene	Chr8:36092680-36140739 (+)
NZO/HlLtJ	ENSMUSG00225014466	protein coding gene	Chr8:49268871-49316208 (+)
PWK/PhJ	ENSLUMG00010012531	protein coding gene	Chr8:35936584-35984538 (+)
SPRET/EiJ	ENSMSPG00010004360	protein coding gene	Chr8:36797023-36831138 (+)
WSB/EiJ	ENSIUOG00005005156	protein coding gene	Chr8:36949621-36997674 (+)

Human Ortholog

VPS37A, VPS37A subunit of ESCRT-I

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VPS37A, VPS37A subunit of ESCRT-I
Synonyms

HCRP1, PQBP2, SPG53
Links

HGNC:24928

NCBI Gene ID: 137492

UniProt: Q8NEZ2
Chr Location

8p22; chr8:17246896-17333455 (+) GRCh38

MGI Vertebrate Homology

Vps37a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VPS37A
Gene Tree

Vps37a

Diseases

1 with human VPS37A associations

				Human Disease	Mouse Models
				hereditary spastic paraplegia 53 IDs hereditary spastic paraplegia 53 DOID:0110805 ICD10CM:G11.4 OMIM:614898 ORDO:319199

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

3
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

646
Tissues

39
cDNA Data

23
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vps37a

ZFIN vps37a

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All Sequences

64
RefSeq

6
UniProt

2
CCDS

CCDS22254.1

Ensembl

ENSMUSG00000031600 (Evidence)
NCBI Gene

52348

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031600	Ensembl Gene Model \| MGI Sequence Detail	38975	C57BL/6J	± kb
transcript	ENSMUST00000238339	Ensembl \| MGI Sequence Detail	1442	Not Applicable
polypeptide	ENSMUSP00000158798	Ensembl \| MGI Sequence Detail	397	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017335 vacuolar protein sorting-associated protein 37A

(term hierarchy)
InterPro Domains

IPR037202 ESCRT assembly domain

IPR029012 Helix hairpin bin domain superfamily

IPR009851 Modifier of rudimentary, Modr

IPR016135 Ubiquitin-conjugating enzyme/RWD-like
GlyGen

Q8CHS8 7 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (6 sites)

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All nucleic 28

cDNA 25

Primer pair 3

Antibodies 1

Microarray probesets 5

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MGI:1914764, MGI:1923157, MGI:2142784

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:360820 Hamamoto K, et al., Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain. Cell Rep. 2024 Dec 24;43(12):115016

TSS for Vps37a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76955	Chr8:40964457-40964485 (+)	-353 bp
Tssr2554	Chr8:40964518-40964529 (+)	-300 bp
Tssr76956	Chr8:40964810-40964828 (+)	-5 bp
Tssr76957	Chr8:40964830-40964903 (+)	43 bp
Tssr76958	Chr8:40971866-40971910 (+)	7,064 bp
Tssr76959	Chr8:40999344-40999373 (+)	34,535 bp
Tssr76960	Chr8:40999390-40999441 (+)	34,592 bp
Tssr76961	Chr8:40999571-40999590 (+)	34,757 bp
Tssr76962	Chr8:40999636-40999658 (+)	34,823 bp
Tssr76963	Chr8:40999662-40999681 (+)	34,848 bp
Tssr76964	Chr8:40999720-40999746 (+)	34,909 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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