About   Help   FAQ
Vps37a Gene Detail
Summary
  • Symbol
    Vps37a
  • Name
    vacuolar protein sorting 37A
  • Synonyms
    2210018P21Rik, 4930592A21Rik, D8Ertd531e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261835
    NCBI Gene: 52348
  • Gene Overview
    MyGene.info: VPS37A
Location & Maps
more
  • Sequence Map
    Chr8:40511783-40551134 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39352 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 23.89 cM, cytoband B1.2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    VPS37A, VPS37A, ESCRT-I subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VPS37A, VPS37A, ESCRT-I subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HCRP1, PQBP2, SPG53
  • Links
    NCBI Gene ID: 137492
    neXtProt AC: NX_Q8NEZ2

  • Chr Location
    8p22; chr8:17246892-17298024 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human VPS37A associations

Human Disease Mouse Models
       Spastic Paraplegia 53, Autosomal Recessive; SPG53   OMIM: 614898
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    5
  • Gene trapped
    3
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 52348 NCBI Gene Model | MGI Sequence Detail 39352 C57BL/6J ±  kb
transcript NM_033560 RefSeq | MGI Sequence Detail 6379 C57BL/6  
polypeptide Q8CHS8 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    450 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000017335 vacuolar protein sorting-associated protein 37A
  • InterPro Domains
    IPR009851 Modifier of rudimentary, Modr
    IPR016135 Ubiquitin-conjugating enzyme/RWD-like
Molecular
Reagents
less
  • All nucleic 24
    cDNA 23
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1914764, MGI:1923157, MGI:2142784
References
more
  • Summaries
    All 30
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:184769 Xue W, et al., A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8212-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory