Wnt2b
Gene Detail

Symbol Name ID

Wnt2b wingless related MMTV integration site 2b MGI:1261834

Synonyms

Wnt13

Feature Type

protein coding gene

Genetic Map

Chromosome 3

45.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:104944805-104961709 bp, - strand From NCBI annotation of GRCm38   16905 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22526  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt2b

Human homologs

Human Homolog		WNT2B, wingless-type MMTV integration site family, member 2B
NCBI Gene ID		7482
neXtProt AC		NX_Q93097
Human Synonyms		WNT13, XWNT2
Human Chr (Location)		1p13; chr1:113010040-113063910 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit no discernable phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	canonical Wnt receptor signaling pathway, cell-cell signaling, ...
Component	extracellular region, extracellular space, ...
Function	frizzled binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (88 records)
Data Summary: Results (392)    Tissues (225)    Images (97)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	358
RT-PCR	32
RNase protection	2

cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(1) cDNA(17) Primer pair(9) Other(5)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000027840 (Evidence)
Entrez Gene	22414 (Evidence)
UniGene	10740
DFCI	TC1587834
DoTS	DT.55110411
NIA Mouse Gene Index	U024469
Consensus CDS Project	CCDS17706.1
International Mouse Knockout Project Status	Wnt2b

Sequences

Length	Strain/Species
genomic	22414	NCBI Gene Model | MGI Sequence Detail	16905	C57BL/6J
transcript	NM_009520	RefSeq | MGI Sequence Detail	3573	C57BL/6
polypeptide	O70283	UniProt | EBI | MGI Sequence Detail	389	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(77 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR009140	Wnt-2 protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017441	protein Wnt-2b

Graphical View of Protein Domain Structure

References

(Earliest) J:47698 Zakin LD, et al., Structure and expression of Wnt13, a novel mouse Wnt2 related gene. Mech Dev. 1998 Apr;73(1):107-16
(Latest) J:193325 Boj SF, et al., Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
All references(122)