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Mn1 Gene Detail
Summary
  • Symbol
    Mn1
  • Name
    meningioma 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261813
    NCBI Gene: 433938
  • Gene Overview
    MyGene.info: MN1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:111418166-111457025 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261813
protein coding gene Chr5:111417362-111457033 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029898
protein coding gene Chr5:113914847-113957754 (+)
A/J MGP_AJ_G0029864
protein coding gene Chr5:109504342-109544189 (+)
AKR/J MGP_AKRJ_G0029802
protein coding gene Chr5:112981287-113020828 (+)
BALB/cJ MGP_BALBcJ_G0029875
protein coding gene Chr5:110876052-110917114 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0030328
protein coding gene Chr5:118391570-118434052 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027557
protein coding gene Chr5:104347198-104386815 (+)
CAST/EiJ MGP_CASTEiJ_G0029003
protein coding gene Chr5:112293550-112338996 (+)
CBA/J MGP_CBAJ_G0029562
protein coding gene Chr5:122813959-122859585 (+)
DBA/2J MGP_DBA2J_G0029712
protein coding gene Chr5:109582067-109621937 (+)
FVB/NJ MGP_FVBNJ_G0029669
protein coding gene Chr5:108270186-108313905 (+)
LP/J MGP_LPJ_G0029800
protein coding gene Chr5:114495295-114538245 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029700
protein coding gene Chr5:127441307-127485156 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030369
protein coding gene Chr5:112412430-112452861 (+)
PWK/PhJ MGP_PWKPhJ_G0028717
protein coding gene Chr5:108165721-108205950 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028555
protein coding gene Chr5:109885584-109925016 (+)
WSB/EiJ MGP_WSBEiJ_G0029079
protein coding gene Chr5:112908592-112950677 (+)



Homology
more
  • Human Ortholog
    MN1, MN1 proto-oncogene, transcriptional regulator
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MN1, MN1 proto-oncogene, transcriptional regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ353E16.2, MGCR, MGCR1, MGCR1-PEN
  • Links
    NCBI Gene ID: 4330
    neXtProt AC: NX_Q10571
    UniProt: Q10571

  • Chr Location
    22q12.1; chr22:27748277-27801498 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37620
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MN1
  • Gene Tree
    Mn1
Human Diseases
more
  • Diseases
    1 with human MN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice die shortly after birth due to cleft palate. Development of several bones in the skull was abnormal with completely absent alisphenoid, squamosal, and vomer bones, hypoplastic basisphenoid, pterygoid, and presphenoid bones, and thinfrontal, parietal, and interparietal bones.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 433938 NCBI Gene Model | MGI Sequence Detail 38860 C57BL/6J ±  kb
    transcript NM_001081235 RefSeq | MGI Sequence Detail 6844 C57BL/6  
    polypeptide D3YWE6 UniProt | EBI | MGI Sequence Detail 1297 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 46

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:3034798, MGI:3505791
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:244712 Navarro N, et al., Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?. G3 (Bethesda). 2016 May 03;6(5):1153-63

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory