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Mn1
Gene Detail
 Symbol
Name
ID
Mn1
meningioma 1
MGI:1261813
Feature Type protein coding gene
Genetic Map
Chromosome 5
53.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:111417362-111457033 bp, + strand
From VEGA annotation of GRCm38

  39672 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37620  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Mn1

Human
homologs
Human Homolog MN1, meningioma (disrupted in balanced translocation) 1
NCBI Gene ID 4330
neXtProt AC  NX_Q10571
Human Synonyms  dJ353E16.2, MGCR, MGCR1, MGCR1-PEN
Human Chr (Location)  22q12.1; chr22:27748277-27801498 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MN1
Alleles
and
phenotypes
All alleles(4) : Targeted(2) Gene trapped(2)
 
Homozygous null mice die shortly after birth due to cleft palate. Development of several bones in the skull was abnormal with completely absent alisphenoid, squamosal, and vomer bones, hypoplastic basisphenoid, pterygoid, and presphenoid bones, and thin frontal, parietal, and interparietal bones.
 
Gene Ontology
(GO)
classifications
All GO classifications: (1 annotations)
Process intramembranous ossification
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (145)    Tissues (22)    Images (24)
Theiler Stages: 17, 23
Assay TypeResults
RNA in situ 145
cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(45) cDNA(45)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000028670 (Evidence)
Ensembl Gene ModelENSMUSG00000070576 (Evidence)
Entrez Gene433938 (Evidence)
UniGene332576
DFCITC1641154
DoTSDT.101367755, DT.530544
NIA Mouse Gene IndexU055132
Consensus CDS ProjectCCDS39214.1
International Mouse Knockout Project StatusMn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028670 VEGA Gene Model | MGI Sequence Detail 39672 C57BL/6J ±  kb
transcript OTTMUST00000071015 VEGA | MGI Sequence Detail 6860 Not Applicable 
polypeptide OTTMUSP00000036300 VEGA | MGI Sequence Detail 1297 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(296 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000029632 tumor suppressor protein MN1
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(30)
Other
accession IDs
MGI:3034798, MGI:3505791

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory