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Rad51d Gene Detail
Summary
  • Symbol
    Rad51d
  • Name
    RAD51 paralog D
  • Synonyms
    R51H3, Rad51l3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261809
    NCBI Gene: 19364
  • Gene Overview
    MyGene.info: RAD51D
Location & Maps
more
  • Sequence Map
    Chr11:82876434-82890614 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14181 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 50.30 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    RAD51D, RAD51 paralog D
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAD51D, RAD51 paralog D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BROVCA4, R51H3, RAD51L3, TRAD
  • Links
    NCBI Gene ID: 5892
    neXtProt AC: NX_O75771

  • Chr Location
    17q11; chr17:35099792-35119869 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RAD51D associations

Human Disease Mouse Models
       Breast-Ovarian Cancer, Familial, Susceptibility to, 4; BROVCA4   OMIM: 614291
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Targeted
    4
  • Genomic Mutations
    2 involving Rad51d
  • Incidental Mutations
    APF , CvDC
Mice homozygous for disruptions in this gene die as embryos before E11.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000932 VEGA Gene Model | MGI Sequence Detail 14181 C57BL/6J ±  kb
transcript OTTMUST00000001822 VEGA | MGI Sequence Detail 3426 Not Applicable  
polypeptide OTTMUSP00000000877 VEGA | MGI Sequence Detail 329 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    156 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    13 Sequences
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR013632 DNA recombination and repair protein Rad51-like, C-terminal
    IPR016467 DNA recombination and repair protein, RecA-like
    IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 19
    cDNA 16
    Primer pair 3

    Microarray probesets 7
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:47042 Cartwright R, et al., Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family. Nucleic Acids Res. 1998 Apr 1;26(7):1653-9
  • Latest
    J:175085 Le Masson F, et al., Identification of Heat Shock Factor 1 Molecular and Cellular Targets during Embryonic and Adult Female Meiosis. Mol Cell Biol. 2011 Aug;31(16):3410-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory