Apba2
Gene Detail

Symbol Name ID

Apba2 amyloid beta (A4) precursor protein-binding, family A, member 2 MGI:1261791

Synonyms

Mint 2, X11L, X11-like

Feature Type

protein coding gene

Genetic Map

Chromosome 7

34.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr7:64501706-64753870 bp, + strand From VEGA annotation of GRCm38   252165 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4021  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Apba2

Human homologs

Human Homolog		APBA2, amyloid beta (A4) precursor protein-binding, family A, member 2
NCBI Gene ID		321
neXtProt AC		NX_Q99767
Human Synonyms		D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11-BETA, X11L
Human Chr (Location)		15q11-q12; chr15:29213840-29410518 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene show a selective deficit in motivated approach behavior, but not in motivated avoidance behavior.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	in utero embryonic development, locomotory behavior, ...
Component	plasma membrane
Function	beta-amyloid binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (240)    Tissues (112)    Images (43)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	240

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) cDNA(26) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023522 (Evidence)
Ensembl Gene Model	ENSMUSG00000030519 (Evidence)
Entrez Gene	11784 (Evidence)
UniGene	4657
DFCI	TC1581358
DoTS	DT.110996248, DT.40146239, DT.87043023
NIA Mouse Gene Index	U008180
Consensus CDS Project	CCDS21335.1
International Mouse Knockout Project Status	Apba2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023522	VEGA Gene Model | MGI Sequence Detail	252165	C57BL/6J
transcript	OTTMUST00000057321	VEGA | MGI Sequence Detail	3313	Not Applicable
polypeptide	OTTMUSP00000027637	VEGA | MGI Sequence Detail	750	Not Applicable

All sequences(43) RefSeq(2) UniProt(6)

Polymorphisms

PCR(1) : SNPs(1380 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001478	PDZ domain
InterPro	IPR006020	Phosphotyrosine interaction domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000004116	amyloid beta A4 precursor protein-binding family A member 2

References

(Earliest) J:22438 Duclos F, et al., Comparison of primary structure of a neuron-specific protein, X11, between human and mouse. Mamm Genome. 1995 Jan;6(1):57-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(37)