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Apba2
Gene Detail
 Symbol
Name
ID
Apba2
amyloid beta (A4) precursor protein-binding, family A, member 2
MGI:1261791
Synonyms Mint 2, X11L, X11-like
Feature Type protein coding gene
Genetic Map
Chromosome 7
34.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:64501706-64753870 bp, + strand
From VEGA annotation of GRCm38

  252165 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4021  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Apba2

Human
homologs
Human Homolog APBA2, amyloid beta (A4) precursor protein-binding, family A, member 2
NCBI Gene ID 321
neXtProt AC  NX_Q99767
Human Synonyms  D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11-BETA, X11L
Human Chr (Location)  15q11-q12; chr15:28919367-29118315 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene show a selective deficit in motivated approach behavior, but not in motivated avoidance behavior.
 
Interactions
Apba2 interacts with 90 markers (Mir7-1, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process in utero embryonic development, locomotory behavior, ...
Component plasma membrane
Function beta-amyloid binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (240)    Tissues (112)    Images (43)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 240
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) cDNA(26) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023522 (Evidence)
Ensembl Gene ModelENSMUSG00000030519 (Evidence)
Entrez Gene11784 (Evidence)
UniGene4657
DFCITC1581358, TC1625777
DoTSDT.101371563, DT.110996248, DT.40146239, DT.87043023, DT.94227740
NIA Mouse Gene IndexU008180
Consensus CDS ProjectCCDS21335.1
International Mouse Knockout Project StatusApba2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023522 VEGA Gene Model | MGI Sequence Detail 252165 C57BL/6J ±  kb
transcript OTTMUST00000057321 VEGA | MGI Sequence Detail 3313 Not Applicable 
polypeptide OTTMUSP00000027637 VEGA | MGI Sequence Detail 750 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(12) UniProt(6)
Polymorphisms PCR(1) : SNPs within 2kb(3080 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000004116 amyloid beta A4 precursor protein-binding family A member 2
References (Earliest) J:22438 Duclos F, et al., Comparison of primary structure of a neuron-specific protein, X11, between human and mouse. Mamm Genome. 1995 Jan;6(1):57-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory