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Apba2 Gene Detail
Summary
  • Symbol
    Apba2
  • Name
    amyloid beta (A4) precursor protein-binding, family A, member 2
  • Synonyms
    Mint 2, X11L, X11-like
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261791
    NCBI Gene: 11784
Location & Maps
more
  • Sequence Map
    Chr7:64501706-64753870 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      252165 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    APBA2, amyloid beta precursor protein binding family A member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    APBA2, amyloid beta precursor protein binding family A member 2
    Orthology source: HomoloGene
  • Synonyms
    D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11-BETA, X11L
  • Links
    NCBI Gene ID: 321
    neXtProt AC: NX_Q99767

  • Chr Location
    15q11-q12; chr15:28885994-29118315 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4021
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: APBA2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Apba2 mouse models

Human Disease Mouse Models
       Alzheimer Disease; AD   OMIM: 104300
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Apba2
  • Incidental Mutations
Mice homozygous for disruptions in this gene show a selective deficit in motivated approach behavior, but not in motivated avoidance behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023522 VEGA Gene Model | MGI Sequence Detail 252165 C57BL/6J ±  kb
transcript OTTMUST00000057321 VEGA | MGI Sequence Detail 3313 Not Applicable  
polypeptide OTTMUSP00000027637 VEGA | MGI Sequence Detail 750 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3080 from dbSNP Build 137
  • PCR
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004116 amyloid beta A4 precursor protein-binding family A member 2
  • InterPro Domains
    IPR030529 Amyloid beta A4 precursor protein-binding family A member 2
    IPR001478 PDZ domain
    IPR011993 PH domain-like
    IPR006020 PTB/PI domain
Molecular
Reagents
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  • All nucleic 28
    cDNA 26
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 8
    Phenotypes 17
  • Earliest
    J:22438 Duclos F, et al., Comparison of primary structure of a neuron-specific protein, X11, between human and mouse. Mamm Genome. 1995 Jan;6(1):57-8
  • Latest
    J:215945 Sullivan SE, et al., Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid beta generation. J Biol Chem. 2014 May 30;289(22):15374-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory