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Cyria Gene Detail
Summary
  • Symbol
    Cyria
  • Name
    CYFIP related Rac1 interactor A
  • Synonyms
    2410157M17Rik, D12Ertd553e, Fam49a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261783
    NCBI Gene: 76820
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:12312140-12430966 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 5.63 cM, cytoband A2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6431 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261783
 protein coding gene Chr12:12312136-12430966 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019602
 protein coding gene Chr12:9463514-9580532 (+)
A/J MGP_AJ_G0019569
 protein coding gene Chr12:9170621-9280693 (+)
AKR/J MGP_AKRJ_G0019539
 protein coding gene Chr12:9724022-9845433 (+)
BALB/cJ MGP_BALBcJ_G0019545
 protein coding gene Chr12:9351390-9461594 (+)
C3H/HeJ MGP_C3HHeJ_G0019350
 protein coding gene Chr12:9542333-9656584 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019993
 protein coding gene Chr12:9816561-9935069 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017620
 protein coding gene Chr12:8851464-8960881 (+)
CAST/EiJ MGP_CASTEiJ_G0018906
 protein coding gene Chr12:9444503-9557468 (+)
CBA/J MGP_CBAJ_G0019321
 protein coding gene Chr12:10489458-10613566 (+)
DBA/2J MGP_DBA2J_G0019434
 protein coding gene Chr12:9122868-9232038 (+)
FVB/NJ MGP_FVBNJ_G0019425
 protein coding gene Chr12:9039219-9146910 (+)
LP/J MGP_LPJ_G0019505
 protein coding gene Chr12:9565345-9685038 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019459
 protein coding gene Chr12:10300735-10418150 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020032
 protein coding gene Chr12:9385573-9483071 (+)
PWK/PhJ MGP_PWKPhJ_G0018672
 protein coding gene Chr12:9189161-9304432 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018462
 protein coding gene Chr12:9503656-9618736 (+)
WSB/EiJ MGP_WSBEiJ_G0018957
 protein coding gene Chr12:9451048-9565793 (+)



Homology
more
  • Human Ortholog
    CYRIA, CYFIP related Rac1 interactor A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYRIA, CYFIP related Rac1 interactor A
  • Synonyms
    CYRI-A, FAM49A
  • Links
    NCBI Gene ID: 81553
    UniProt: Q9H0Q0

  • Chr Location
    2p24.2; chr2:16549459-16666331 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    13
  • cDNA Data
    71
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020589 Ensembl Gene Model | MGI Sequence Detail 118827 C57BL/6J ±  kb
    transcript ENSMUST00000069005 Ensembl | MGI Sequence Detail 1771 Not Applicable  
    polypeptide ENSMUSP00000068125 Ensembl | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      cDNA 71
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924070, MGI:6391261
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:361791 Park CS, et al., Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells. Elife. 2024 Aug 19;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory