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Mcpt8
Gene Detail
Symbol

Name
ID
Mcpt8
mast cell protease 8
MGI:1261780
Synonyms
MMCP-8
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:56082166-56085216 bp, - strand
From Ensembl annotation of GRCm38

  3051 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: trypsin
Gene Tree: Mcpt8
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in mutation that allows diphtheria toxin-mediated basophil depletion before the second tick infestation exhibit loss of acquired tick resistance.
 
Interactions
Mcpt8 interacts with 27 markers (Mir17, Mir20b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process immune response, protein processing, ...
Component cytoplasm, extracellular region, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (22)    Tissues (1)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 22
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022157 (Evidence)
Entrez Gene 17231 (Evidence)
UniGene 41979
DFCI TC1588944
DoTS DT.521777
NIA Mouse Gene Index U035599
EC 3.4.21.-
Consensus CDS Project CCDS27141.1
International Mouse Phenotyping Consortium Status Mcpt8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022157 Ensembl Gene Model | MGI Sequence Detail 3051 C57BL/6J ±  kb
transcript ENSMUST00000015594 Ensembl | MGI Sequence Detail 855 Not Applicable 
polypeptide ENSMUSP00000015594 Ensembl | MGI Sequence Detail 247 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000010905 mast cell protease 8
References
(Earliest) J:46663 Lutzelschwab C, et al., Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases. Eur J Immunol. 1998 Mar;28(3):1022-33
(Latest) J:207720 Pozniak CD, et al., Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration. J Exp Med. 2013 Nov 18;210(12):2553-67
All references(34)
Other
accession IDs
MGI:2145855

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory