Mcpt8
Gene Detail

Symbol Name ID

Mcpt8 mast cell protease 8 MGI:1261780

Synonyms

MMCP-8

Feature Type

protein coding gene

Genetic Map

Chromosome 14

28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:56082163-56085197 bp, - strand From NCBI annotation of GRCm38   3035 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40626  Vertebrate Homology Class
1 mouse; 6 rat; 4 cattle

Protein SuperFamily: trypsin
Gene Tree: Mcpt8

Alleles and phenotypes

All alleles(3) : Targeted(3)

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	proteolysis
Component	extracellular region
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (22)    Tissues (1)    Images (22)
Theiler Stages: 23

Assay Type	Results
RNA in situ	22

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(7)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022157 (Evidence)
Entrez Gene	17231 (Evidence)
UniGene	41979
DFCI	TC1588944
DoTS	DT.521777
NIA Mouse Gene Index	U035599
EC	3.4.21.-
Consensus CDS Project	CCDS27141.1
International Mouse Knockout Project Status	Mcpt8

Sequences

Length	Strain/Species
genomic	17231	NCBI Gene Model | MGI Sequence Detail	3035	C57BL/6J
transcript	NM_008572	RefSeq | MGI Sequence Detail	845	Leaden x A1 F1*
polypeptide	P43430	UniProt | EBI | MGI Sequence Detail	247	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(71 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000010905	mast cell protease 8

Graphical View of Protein Domain Structure

References

(Earliest) J:46663 Lutzelschwab C, et al., Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases. Eur J Immunol. 1998 Mar;28(3):1022-33
(Latest) J:194750 Egawa M, et al., Inflammatory Monocytes Recruited to Allergic Skin Acquire an Anti-inflammatory M2 Phenotype via Basophil-Derived Interleukin-4. Immunity. 2013 Mar 21;38(3):570-80
All references(31)

Other accession IDs

MGI:2145855