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Mcpt8 Gene Detail
Summary
  • Symbol
    Mcpt8
  • Name
    mast cell protease 8
  • Synonyms
    MMCP-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261780
    NCBI Gene: 17231
Location & Maps
more
  • Sequence Map
    Chr14:56082166-56085216 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3051 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Mcpt8
  • Incidental Mutations
Mice homozygous for a knock-in mutation that allows diphtheria toxin-mediated basophil depletion before the second tick infestation exhibit loss of acquired tick resistance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022157 Ensembl Gene Model | MGI Sequence Detail 3051 C57BL/6J ±  kb
transcript ENSMUST00000015594 Ensembl | MGI Sequence Detail 855 Not Applicable  
polypeptide ENSMUSP00000015594 Ensembl | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    111 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010905 mast cell protease 8
  • EC
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 3
Other
Accession IDs
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MGI:2145855
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:46663 Lutzelschwab C, et al., Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases. Eur J Immunol. 1998 Mar;28(3):1022-33
  • Latest
    J:222287 Cheng LE, et al., IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015 Apr 6;212(4):513-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory