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Mcpt8
Gene Detail
 Symbol
Name
ID
Mcpt8
mast cell protease 8
MGI:1261780
Synonyms MMCP-8
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:56082163-56085197 bp, - strand
From NCBI annotation of GRCm38

  3035 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: trypsin
Gene Tree: Mcpt8
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in mutation that allows diphtheria toxin-mediated basophil depletion before the second tick infestation exhibit loss of acquired tick resistance.
 
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component extracellular region
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (22)    Tissues (1)    Images (22)
Theiler Stages: 23
Assay TypeResults
RNA in situ 22
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022157 (Evidence)
Entrez Gene17231 (Evidence)
UniGene41979
DFCITC1588944
DoTSDT.521777
NIA Mouse Gene IndexU035599
EC3.4.21.-
Consensus CDS ProjectCCDS27141.1
International Mouse Knockout Project StatusMcpt8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17231 NCBI Gene Model | MGI Sequence Detail 3035 C57BL/6J ±  kb
transcript NM_008572 RefSeq | MGI Sequence Detail 845 Leaden x A1 F1* 
polypeptide P43430 UniProt | EBI | MGI Sequence Detail 247 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000010905 mast cell protease 8
Graphical View of Protein Domain Structure
References (Earliest) J:46663 Lutzelschwab C, et al., Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases. Eur J Immunol. 1998 Mar;28(3):1022-33
(Latest) J:207720 Pozniak CD, et al., Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration. J Exp Med. 2013 Nov 18;210(12):2553-67
All references(34)
Other
accession IDs
MGI:2145855

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory