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Lsamp
Gene Detail
Symbol

Name
ID
Lsamp
limbic system-associated membrane protein
MGI:1261760
Synonyms
B130007O04Rik, D930023J12Rik, Lam, Lamp
Feature Type
protein coding gene
Genetic Map
Chromosome 16
28.26 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:39984361-42181679 bp, + strand
From VEGA annotation of GRCm38

  2197319 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LSAMP
Gene Tree: Lsamp

Human
homologs
LSAMP, limbic system-associated membrane protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4045
neXtProt AC: NX_Q13449

Human Synonyms: IGLON3, LAMP

Human Chr (Location): 3q13.2-q21; chr3:115802363-116445542 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for mutations in this gene are hyperresponsive to novel environments. Mice homozygous for another knock-out allele exhibit reduced barbering, whisker trimming, anxiety, dominance, and aggression.
 
Interactions
Lsamp interacts with 518 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell adhesion, locomotory exploration behavior, ...
Component anchored component of membrane, cell-cell junction, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (177)    Tissues (177)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 177
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lsamp    NEW 
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(12) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000016989 (Evidence)
Ensembl Gene Model ENSMUSG00000061080 (Evidence)
Entrez Gene 268890 (Evidence)
DFCI TC1602057, TC1617097, TC1590200, TC1605077, TC1675048, TC1629681, TC1642189
DoTS DT.94182655, DT.55275082, DT.91381156, DT.50315891, DT.60101052, DT.110737417, DT.101361285
Consensus CDS Project CCDS28176.1
International Mouse Phenotyping Consortium Status Lsamp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016989 VEGA Gene Model | MGI Sequence Detail 2197319 C57BL/6J ±  kb
transcript OTTMUST00000122267 VEGA | MGI Sequence Detail 3411 Not Applicable 
polypeptide OTTMUSP00000067126 VEGA | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(6) UniProt(9)
Polymorphisms
SNPs within 2kb(11937 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000009951 limbic system-associated membrane protein
References
(Earliest) J:41462 Zhang JH, et al., Dynamic expression suggests multiple roles of the eph family receptor brain-specific kinase (Bsk) during mouse neurogenesis. Brain Res Mol Brain Res. 1997 Jul;47(1-2):202-14
(Latest) J:215618 Schmidt ER, et al., Subdomain-mediated axon-axon signaling and chemoattraction cooperate to regulate afferent innervation of the lateral habenula. Neuron. 2014 Jul 16;83(2):372-87
All references(51)
Other
accession IDs
MGI:1095398, MGI:2146612, MGI:2442078, MGI:3041227

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory