Tbx10
Gene Detail

Symbol Name ID

Tbx10 T-box 10 MGI:1261436

Synonyms

Tbx13, Tbx7

Feature Type

protein coding gene

Genetic Map

Chromosome 19

3.71 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr19:3992752-3999511 bp, + strand From Ensembl annotation of GRCm38   6760 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37399  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Tbx10

Human homologs

Human Homolog		TBX10, T-box 10
NCBI Gene ID		347853
neXtProt AC		NX_O75333
Human Synonyms		TBX13, TBX7
Human Chr (Location)		11q13.2; chr11:67398774-67407031 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Spontaneous(1)
 

Mice homozygous for a gain of function mutation die perinatally with cleft lip and cleft palate; heterozygotes show penetrance and strain effects - they generally circle and head-toss, but are not deaf, lack the macula of utriculus and show defects of the labyrinths in the vestibular region.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	regulation of transcription, DNA-dependent, transcription, DNA-dependent
Component	nucleus
Function	DNA binding, sequence-specific DNA binding transcription factor activity

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (76)    Tissues (63)    Images (19)
Theiler Stages: 14, 15, 16, 17, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	61
Northern blot	11
RT-PCR	4

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(2) cDNA(11) Primer pair(1) Other(2)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000037477 (Evidence)
Entrez Gene	109575 (Evidence)
UniGene	246555
DFCI	TC1590736
DoTS	DT.102554792, DT.103562169
NIA Mouse Gene Index	U038760
Consensus CDS Project	CCDS29407.1
International Mouse Knockout Project Status	Tbx10

Sequences

Length	Strain/Species
genomic	ENSMUSG00000037477	Ensembl Gene Model | MGI Sequence Detail	6760	C57BL/6J
transcript	ENSMUST00000041871	Ensembl | MGI Sequence Detail	1777	Not Applicable
polypeptide	ENSMUSP00000037401	Ensembl | MGI Sequence Detail	385	Not Applicable

All sequences(19) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(26 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR001699	Transcription factor, T-box
InterPro	IPR018186	Transcription factor, T-box, conserved site
Protein Ontology	PR:000016144	T-box transcription factor TBX10

References

(Earliest) J:24773 Lane PW, New mutants: Dancer, Athetoid, and mahogany. Mouse News Lett. 1958;19:25
(Latest) J:191667 Jayakody SA, et al., SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest. 2012 Oct 1;122(10):3635-46
All references(52)

Other accession IDs

MGD-MRK-8807, MGI:1201667, MGI:94868