Tbx10 MGI Mouse Gene Detail - MGI:1261436

Symbol

Tbx10
Name

T-box 10
Synonyms

Tbx13, Tbx7

Feature Type

protein coding gene
IDs

MGI:1261436
NCBI Gene: 109575
Alliance

gene page

Sequence Map

Chr19:4042752-4049512 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 3.71 cM, cytoband A
Mapping Data

14 experiments

SNPs within 2kb

43 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261436	protein coding gene	Chr19:4042752-4049512 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024637	protein coding gene	Chr19:811436-818195 (+)
A/J	MGP_AJ_G0024605	protein coding gene	Chr19:771101-777860 (+)
AKR/J	MGP_AKRJ_G0024576	protein coding gene	Chr19:801619-808378 (+)
BALB/cJ	MGP_BALBcJ_G0024603	protein coding gene	Chr19:782818-789577 (+)
C3H/HeJ	MGP_C3HHeJ_G0024371	protein coding gene	Chr19:799419-807795 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025051	protein coding gene	Chr19:820100-826859 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022480	protein coding gene	Chr19:736478-742896 (+)
CAST/EiJ	MGP_CASTEiJ_G0023843	protein coding gene	Chr19:810968-820725 (+)
CBA/J	MGP_CBAJ_G0024342	protein coding gene	Chr19:901034-907793 (+)
DBA/2J	MGP_DBA2J_G0024470	protein coding gene	Chr19:749522-756281 (+)
FVB/NJ	MGP_FVBNJ_G0024437	protein coding gene	Chr19:762314-769067 (+)
LP/J	MGP_LPJ_G0024557	protein coding gene	Chr19:810271-818486 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024468	protein coding gene	Chr19:855666-862396 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025099	protein coding gene	Chr19:794419-801178 (+)
PWK/PhJ	MGP_PWKPhJ_G0023590	protein coding gene	Chr19:787305-794053 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023396	protein coding gene	Chr19:791692-798443 (+)
WSB/EiJ	MGP_WSBEiJ_G0023906	protein coding gene	Chr19:786669-793424 (+)

Human Ortholog

TBX10, T-box transcription factor 10

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBX10, T-box transcription factor 10
Synonyms

TBX13, TBX7
Links

HGNC:11593

NCBI Gene ID: 347853

neXtProt AC: NX_O75333

UniProt: O75333
Chr Location

11q13.2; chr11:67631303-67641754 (-) GRCh38

MGI Vertebrate Homology

Tbx10 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TBX10
Gene Tree

Tbx10

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Phenotype Summary

37 phenotypes from 2 alleles in 3 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Spontaneous

1
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gain of function mutation die perinatally with cleft lip and cleft palate; heterozygotes show penetrance and strain effects - they generally circle and head-toss, but are not deaf, lack the macula of utriculus and show defects of the labyrinths in the vestibular region.

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

819
Tissues

71
cDNA Data

12
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

4
UniProt

1
CCDS

CCDS29407.1

Ensembl

ENSMUSG00000037477 (Evidence)
NCBI Gene

109575

			Length	Strain/Species	Flank
genomic	109575	NCBI Gene Model \| MGI Sequence Detail	6761	C57BL/6J	± kb
transcript	NM_001001320	RefSeq \| MGI Sequence Detail	1795	ZRU/MplStud
polypeptide	Q810F8	UniProt \| EBI \| MGI Sequence Detail	385	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016144 T-box transcription factor TBX10

(term hierarchy)
InterPro Domains

IPR008967 p53-like transcription factor, DNA-binding domain superfamily

IPR036960 T-box superfamily

IPR001699 T-box transcription factor

IPR046360 T-box transcription factor, DNA-binding domain

IPR018186 Transcription factor, T-box, conserved site

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All nucleic 17

Genomic 2

cDNA 12

Primer pair 1

Other 2

Microarray probesets 1

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MGD-MRK-8807, MGI:1201667, MGI:94868

Summaries

All 54

Developmental Gene Expression 14

Gene Ontology 2

Phenotypes 19
Earliest

J:5022 Deol MS, et al., A new gene affecting the morphogenesis of the vestibular part of the inner ear in the mouse. J Embryol Exp Morphol. 1966 Dec;16(3):543-58
Latest

J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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