Olr1
Gene Detail

Symbol Name ID

Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 MGI:1261434

Synonyms

LOX-1, Scare1, SR-EI

Feature Type

protein coding gene

Genetic Map

Chromosome 6

63.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:129485246-129507165 bp, - strand From VEGA annotation of GRCm38   21920 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1910  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Olr1

Human homologs

Human Homolog		OLR1, oxidized low density lipoprotein (lectin-like) receptor 1
NCBI Gene ID		4973
neXtProt AC		NX_P78380
Human Synonyms		CLEC8A, LOX1, LOXIN, SCARE1, SLOX1
Human Chr (Location)		12p13.2-p12.3; chr12:10310899-10324790 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human OLR1

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous mutation of this gene results in no obvious phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	cell adhesion, cell death, ...
Component	extracellular region, extrinsic to plasma membrane, ...
Function	carbohydrate binding, low-density lipoprotein receptor activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (48)    Tissues (15)   
Theiler Stages: 9, 11, 13, 15, 19, 22, 26, 28

Assay Type	Results
RNA in situ	7
RT-PCR	41

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(1) cDNA(11) Primer pair(3) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034583 (Evidence)
Ensembl Gene Model	ENSMUSG00000030162 (Evidence)
Entrez Gene	108078 (Evidence)
UniGene	293626
DFCI	TC1633099, TC1663157, TC1678207
DoTS	DT.101362207, DT.91283913, DT.99851250
NIA Mouse Gene Index	U027917
Consensus CDS Project	CCDS20588.1
International Mouse Knockout Project Status	Olr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034583	VEGA Gene Model | MGI Sequence Detail	21920	C57BL/6J
transcript	OTTMUST00000087744	VEGA | MGI Sequence Detail	3570	Not Applicable
polypeptide	OTTMUSP00000047764	VEGA | MGI Sequence Detail	363	Not Applicable

All sequences(33) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(161 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001304	C-type lectin
InterPro	IPR016187	C-type lectin fold
InterPro	IPR016186	C-type lectin-like
Protein Ontology	PR:000011634	oxidized low-density lipoprotein receptor 1

References

(Earliest) J:47339 Hoshikawa H, et al., High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1). Biochem Biophys Res Commun. 1998 Apr 28;245(3):841-6
(Latest) J:179076 Vecchione L, et al., Functional characterization and expression analysis of novel alternative splicing isoforms of Olr1 gene during mouse embryogenesis. Gene. 2012 Jan 1;491(1):5-12
All references(45)