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Endog Gene Detail
Summary
  • Symbol
    Endog
  • Name
    endonuclease G
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261433
    NCBI Gene: 13804
  • Gene Overview
    MyGene.info: ENDOG
Location & Maps
more
  • Sequence Map
    Chr2:30171493-30174069 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2577 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 21.29 cM, cytoband B
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ENDOG, endonuclease G
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ENDOG, endonuclease G
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2021
    neXtProt AC: NX_Q14249

  • Chr Location
    9q34.11; chr9:128818411-128822678 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
    APF
Homozygous null mice are viable and have no detectable abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016745 VEGA Gene Model | MGI Sequence Detail 2577 C57BL/6J ±  kb
transcript OTTMUST00000040620 VEGA | MGI Sequence Detail 1063 Not Applicable  
polypeptide OTTMUSP00000018152 VEGA | MGI Sequence Detail 294 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    4 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    Genomic 6
    cDNA 7

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:43924 Prats E, et al., Characterization and expression of the mouse endonuclease G gene. DNA Cell Biol. 1997 Sep;16(9):1111-22
  • Latest
    J:218272 Robertson AB, et al., Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination. Nucleic Acids Res. 2014 Dec 1;42(21):13280-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory