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Endog Gene Detail
Summary
  • Symbol
    Endog
  • Name
    endonuclease G
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261433
    NCBI Gene: 13804
  • Gene Overview
    MyGene.info: ENDOG
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:30171493-30174069 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 21.29 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261433
protein coding gene Chr2:30171407-30174069 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025556
protein coding gene Chr2:28392542-28395118 (+)
A/J MGP_AJ_G0025534
protein coding gene Chr2:27255955-27258531 (+)
AKR/J MGP_AKRJ_G0025503
protein coding gene Chr2:28184445-28187021 (+)
BALB/cJ MGP_BALBcJ_G0025530
protein coding gene Chr2:27384260-27386836 (+)
C3H/HeJ MGP_C3HHeJ_G0025291
protein coding gene Chr2:28112636-28115212 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025975
protein coding gene Chr2:29328265-29330841 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023383
protein coding gene Chr2:26048426-26050956 (+)
CAST/EiJ MGP_CASTEiJ_G0024753
protein coding gene Chr2:28004856-28007444 (+)
CBA/J MGP_CBAJ_G0025268
protein coding gene Chr2:30321647-30324226 (+)
DBA/2J MGP_DBA2J_G0025401
protein coding gene Chr2:27040962-27043538 (+)
FVB/NJ MGP_FVBNJ_G0025364
protein coding gene Chr2:26857441-26860017 (+)
LP/J MGP_LPJ_G0025487
protein coding gene Chr2:28298609-28301185 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025394
protein coding gene Chr2:30217749-30220325 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026033
protein coding gene Chr2:28098248-28100824 (+)
PWK/PhJ MGP_PWKPhJ_G0024500
protein coding gene Chr2:26885332-26887941 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024300
protein coding gene Chr2:28191600-28194137 (+)
WSB/EiJ MGP_WSBEiJ_G0024821
protein coding gene Chr2:28230589-28233212 (+)



Homology
more
  • Human Ortholog
    ENDOG, endonuclease G
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ENDOG, endonuclease G
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2021
    neXtProt AC: NX_Q14249
    UniProt: Q14249

  • Chr Location
    9q34.11; chr9:128818402-128822676 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and have no detectable abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015337 Ensembl Gene Model | MGI Sequence Detail 2577 C57BL/6J ±  kb
    transcript ENSMUST00000015481 Ensembl | MGI Sequence Detail 1063 Not Applicable  
    polypeptide ENSMUSP00000015481 Ensembl | MGI Sequence Detail 294 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 6
      cDNA 8

      Microarray probesets 4
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:43924 Prats E, et al., Characterization and expression of the mouse endonuclease G gene. DNA Cell Biol. 1997 Sep;16(9):1111-22
    • Latest
      J:251166 Chen D, et al., AKT2 deficiency induces retardation of myocyte development through EndoG-MEF2A signaling in mouse heart. Biochem Biophys Res Commun. 2017 Dec 2;493(4):1410-1417

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory