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Drosha Gene Detail
Summary
  • Symbol
    Drosha
  • Name
    drosha, ribonuclease type III
  • Synonyms
    1110013A17Rik, Etohi2, Rnasen
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261425
    NCBI Gene: 14000
  • Gene Overview
    MyGene.info: DROSHA
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:12824815-12935291 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 5.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1226 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261425
protein coding gene Chr15:12824804-12935291 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021740
protein coding gene Chr15:10073524-10183520 (+)
A/J MGP_AJ_G0021700
protein coding gene Chr15:9757887-9874691 (+)
AKR/J MGP_AKRJ_G0021678
protein coding gene Chr15:10039894-10159798 (+)
BALB/cJ MGP_BALBcJ_G0021707
protein coding gene Chr15:9667407-9783359 (+)
C3H/HeJ MGP_C3HHeJ_G0021483
protein coding gene Chr15:9977505-10095434 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022146
protein coding gene Chr15:10434633-10546627 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019687
protein coding gene Chr15:9284646-9390548 (+)
CAST/EiJ MGP_CASTEiJ_G0020999
protein coding gene Chr15:10097079-10211943 (+)
CBA/J MGP_CBAJ_G0021452
protein coding gene Chr15:10755802-10867837 (+)
DBA/2J MGP_DBA2J_G0021576
protein coding gene Chr15:9617527-9723593 (+)
FVB/NJ MGP_FVBNJ_G0021554
protein coding gene Chr15:9469359-9579278 (+)
LP/J MGP_LPJ_G0021644
protein coding gene Chr15:10011302-10127509 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021579
protein coding gene Chr15:10960195-11073299 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022169
protein coding gene Chr15:10034672-10146311 (+)
PWK/PhJ MGP_PWKPhJ_G0020742
protein coding gene Chr15:9813585-9921720 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020580
protein coding gene Chr15:9967440-10081363 (+)
WSB/EiJ MGP_WSBEiJ_G0021055
protein coding gene Chr15:10020143-10130415 (+)



Homology
more
  • Human Ortholog
    DROSHA, drosha ribonuclease III
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DROSHA, drosha ribonuclease III
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN
  • Links
    NCBI Gene ID: 29102
    neXtProt AC: NX_Q9NRR4
    UniProt: Q9NRR4

  • Chr Location
    5p13.3; chr5:31400494-31532175 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8293
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DROSHA
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 6 alleles in 6 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele and a conditional allele activated in the immune system exhibit increased inflammation in multiple systems, cachexia and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022191 Ensembl Gene Model | MGI Sequence Detail 110477 C57BL/6J ±  kb
    transcript ENSMUST00000090292 Ensembl | MGI Sequence Detail 4519 Not Applicable  
    polypeptide ENSMUSP00000087762 Ensembl | MGI Sequence Detail 1373 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 190
      cDNA 187
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1915895, MGI:2146099
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 9
      Gene Ontology 12
      Phenotypes 31
    • Earliest
      J:46302 Rout UK, et al., Ethanol-induced intracellular calcium mobilization rapidly alters gene expression in the mouse blastocyst. Cell Calcium. 1997 Dec;22(6):463-74
    • Latest
      J:262622 Goncalves IDCG, et al., Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy. Sci Rep. 2018 May 21;8(1):7907

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory