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Naga
Gene Detail
 Symbol
Name
ID
Naga
N-acetyl galactosaminidase, alpha
MGI:1261422
Feature Type protein coding gene
Genetic Map
Chromosome 15
38.56 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:82329532-82338826 bp, - strand
From NCBI annotation of GRCm38

  9295 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:221  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glycosyl hydrolase, Mel1p type
Gene Tree: Naga

Human
homologs
Human Homolog NAGA, N-acetylgalactosaminidase, alpha-
NCBI Gene ID 4668
neXtProt AC  NX_P17050
Human Synonyms  D22S674, GALB
Human Chr (Location)  22q11; chr22:42058334-42070842 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human NAGA
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Radiation induced(1) Targeted(1)
Genomic Mutations involving Naga (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Naga interacts with 97 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process carbohydrate catabolic process, carbohydrate metabolic process, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function alpha-galactosidase activity, alpha-N-acetylgalactosaminidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (183)    Tissues (104)    Images (25)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 183
cDNA source data(81)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) Genomic(13) cDNA(81) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022453 (Evidence)
Entrez Gene17939 (Evidence)
UniGene20325
DFCITC1578328, TC1732483
DoTSDT.534786, DT.94375896
NIA Mouse Gene IndexU036449
EC3.2.1.49
Consensus CDS ProjectCCDS27686.1
International Mouse Knockout Project StatusNaga
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17939 NCBI Gene Model | MGI Sequence Detail 9295 C57BL/6J ±  kb
transcript NM_008669 RefSeq | MGI Sequence Detail 1913 C57BL/6 
polypeptide Q9QWR8 UniProt | EBI | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR000111 Glycoside hydrolase, clan GH-D
InterPro IPR002241 Glycoside hydrolase, family 27
InterPro IPR017853 Glycoside hydrolase, superfamily
InterPro IPR013780 Glycosyl hydrolase, family 13, all-beta
Protein Ontology PR:000010959 alpha-N-acetylgalactosaminidase
Graphical View of Protein Domain Structure
References (Earliest) J:47737 Herrmann T, et al., Molecular cloning, structural organization, sequence, chromosomal assignment, and expression of the mouse alpha-N-acetylgalactosaminidase gene. Gene. 1998 May 12;211(2):205-14
(Latest) J:173543 Harper J, et al., The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10585-90
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory