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Sgpl1 Gene Detail
Summary
  • Symbol
    Sgpl1
  • Name
    sphingosine phosphate lyase 1
  • Synonyms
    D10Xrf456
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261415
    NCBI Gene: 20397
  • Gene Overview
    MyGene.info: SGPL1
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:61098642-61147684 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.14 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    308 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261415
protein coding gene Chr10:61098642-61147703 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017274
protein coding gene Chr10:60400167-60456162 (-)
A/J MGP_AJ_G0017252
protein coding gene Chr10:58609356-58659585 (-)
AKR/J MGP_AKRJ_G0017212
protein coding gene Chr10:60134073-60192952 (-)
BALB/cJ MGP_BALBcJ_G0017212
protein coding gene Chr10:58676213-58734299 (-)
C3H/HeJ MGP_C3HHeJ_G0017035
protein coding gene Chr10:60039090-60090815 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017670
protein coding gene Chr10:62532895-62589124 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015361
protein coding gene Chr10:55585368-55637929 (-)
CAST/EiJ MGP_CASTEiJ_G0016606
protein coding gene Chr10:60016178-60070260 (-)
CBA/J MGP_CBAJ_G0017007
protein coding gene Chr10:64853831-64922788 (-)
DBA/2J MGP_DBA2J_G0017112
protein coding gene Chr10:57884285-57933911 (-)
FVB/NJ MGP_FVBNJ_G0017106
protein coding gene Chr10:57139523-57189739 (-)
LP/J MGP_LPJ_G0017187
protein coding gene Chr10:60802415-60855578 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017134
protein coding gene Chr10:67226881-67283453 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017708
protein coding gene Chr10:59943001-59995813 (-)
PWK/PhJ MGP_PWKPhJ_G0016389
protein coding gene Chr10:57711023-57762691 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016172
protein coding gene Chr10:59288395-59342670 (-)
WSB/EiJ MGP_WSBEiJ_G0016670
protein coding gene Chr10:59868478-59919955 (-)



Homology
more
  • Human Ortholog
    SGPL1, sphingosine-1-phosphate lyase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SGPL1, sphingosine-1-phosphate lyase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NPHS14, S1PL, SPL
  • Links
    NCBI Gene ID: 8879
    neXtProt AC: NX_O95470
    UniProt: O95470

  • Chr Location
    10q22.1; chr10:70815920-70881189 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SGPL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    109 phenotypes from 7 alleles in 8 genetic backgrounds
    2 phenotypes from multigenic genotypes
    6 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit premature death, skeletal and craniofacial defects, kidney defects, hematopoietic defects, decreased body weight and abnormal cell migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20397 NCBI Gene Model | MGI Sequence Detail 49043 C57BL/6J ±  kb
    transcript NM_009163 RefSeq | MGI Sequence Detail 4152 C57BL/6  
    polypeptide Q8R0X7 UniProt | EBI | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2143595
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 42
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:253486 Pirhaji L, et al., Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements. Nat Commun. 2017 Sep 20;8(1):623

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory