About   Help   FAQ
Sgpl1 Gene Detail
Summary
  • Symbol
    Sgpl1
  • Name
    sphingosine phosphate lyase 1
  • Synonyms
    D10Xrf456
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261415
    NCBI Gene: 20397
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:60934421-60983463 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.14 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1112 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261415
 protein coding gene Chr10:60934421-60983482 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017274
 protein coding gene Chr10:60400167-60456162 (-)
A/J MGP_AJ_G0017252
 protein coding gene Chr10:58609356-58659585 (-)
AKR/J MGP_AKRJ_G0017212
 protein coding gene Chr10:60134073-60192952 (-)
BALB/cJ MGP_BALBcJ_G0017212
 protein coding gene Chr10:58676213-58734299 (-)
C3H/HeJ MGP_C3HHeJ_G0017035
 protein coding gene Chr10:60039090-60090815 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017670
 protein coding gene Chr10:62532895-62589124 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015361
 protein coding gene Chr10:55585368-55637929 (-)
CAST/EiJ MGP_CASTEiJ_G0016606
 protein coding gene Chr10:60016178-60070260 (-)
CBA/J MGP_CBAJ_G0017007
 protein coding gene Chr10:64853831-64922788 (-)
DBA/2J MGP_DBA2J_G0017112
 protein coding gene Chr10:57884285-57933911 (-)
FVB/NJ MGP_FVBNJ_G0017106
 protein coding gene Chr10:57139523-57189739 (-)
LP/J MGP_LPJ_G0017187
 protein coding gene Chr10:60802415-60855578 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017134
 protein coding gene Chr10:67226881-67283453 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017708
 protein coding gene Chr10:59943001-59995813 (-)
PWK/PhJ MGP_PWKPhJ_G0016389
 protein coding gene Chr10:57711023-57762691 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016172
 protein coding gene Chr10:59288395-59342670 (-)
WSB/EiJ MGP_WSBEiJ_G0016670
 protein coding gene Chr10:59868478-59919955 (-)



Homology
more
  • Human Ortholog
    SGPL1, sphingosine-1-phosphate lyase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SGPL1, sphingosine-1-phosphate lyase 1
  • Synonyms
    NPHS14, RENI, S1PL, SPL
  • Links
    NCBI Gene ID: 8879
    UniProt: O95470

  • Chr Location
    10q22.1; chr10:70815905-70958701 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SGPL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    104 phenotypes from 6 alleles in 7 genetic backgrounds
    18 phenotypes from multigenic genotypes
    6 images
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit premature death, skeletal and craniofacial defects, kidney defects, hematopoietic defects, decreased body weight and abnormal cell migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1108
  • Tissues
    219
  • cDNA Data
    13
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20397 NCBI Gene Model | MGI Sequence Detail 49043 C57BL/6J ±  kb
    transcript NM_009163 RefSeq | MGI Sequence Detail 4152 ZRU/MplStud  
    polypeptide Q8R0X7 UniProt | EBI | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000014800 sphingosine-1-phosphate lyase 1
      (term hierarchy)
    • EC
      4.1.2.27
    • InterPro Domains
      IPR050477 Group II Amino Acid Decarboxylases
      IPR002129 Pyridoxal phosphate-dependent decarboxylase
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
      IPR015422 Pyridoxal phosphate-dependent transferase, small domain
    • GlyGen
      Q8R0X7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2143595
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 10
      Gene Ontology 14
      Phenotypes 54
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    10/07/2025
    MGI 6.24     		The Jackson Laboratory