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Sgpl1 Gene Detail
Summary
  • Symbol
    Sgpl1
  • Name
    sphingosine phosphate lyase 1
  • Synonyms
    D10Xrf456
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261415
    NCBI Gene: 20397
  • Gene Overview
    MyGene.info: SGPL1
Location & Maps
more
  • Sequence Map
    Chr10:61098642-61147703 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49062 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.14 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SGPL1, sphingosine-1-phosphate lyase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SGPL1, sphingosine-1-phosphate lyase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    S1PL, SPL
  • Links
    NCBI Gene ID: 8879
    neXtProt AC: NX_O95470

  • Chr Location
    10q21; chr10:70815948-70881189 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    107 phenotypes from 7 alleles in 8 genetic backgrounds
    2 phenotypes from multigenic genotypes
    6 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    33
  • Chemically induced (other)
    1
  • Gene trapped
    24
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Sgpl1
  • Incidental Mutations
Mice homozygous for a gene trapped allele exhibit premature death, skeletal and craniofacial defects, kidney defects, hematopoietic defects, decreased body weight and abnormal cell migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031946 VEGA Gene Model | MGI Sequence Detail 49062 C57BL/6J ±  kb
transcript OTTMUST00000079253 VEGA | MGI Sequence Detail 4070 Not Applicable  
polypeptide OTTMUSP00000042252 VEGA | MGI Sequence Detail 568 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    308 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000014800 sphingosine-1-phosphate lyase 1
  • EC
  • InterPro Domains
    IPR002129 Pyridoxal phosphate-dependent decarboxylase
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
Molecular
Reagents
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  • All nucleic 13
    cDNA 13

    Microarray probesets 5
Other
Accession IDs
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MGI:2143595
References
more
  • Summaries
    All 64
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 36
  • Earliest
    J:47955 Zhou J, et al., Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. Biochem Biophys Res Commun. 1998 Jan 26;242(3):502-7
  • Latest
    J:217407 Ihlefeld K, et al., Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts. J Lipid Res. 2015 Jan;56(1):60-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory