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Sgpl1
Gene Detail
Symbol

Name
ID
Sgpl1
sphingosine phosphate lyase 1
MGI:1261415
Synonyms
D10Xrf456
Feature Type
protein coding gene
Genetic Map
Chromosome 10
32.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:61098642-61147703 bp, - strand
From VEGA annotation of GRCm38

  49062 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2897  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SGPL1
Protein SuperFamily: sphingosine-1-phosphate lyase
Gene Tree: Sgpl1

Human
homologs
SGPL1, sphingosine-1-phosphate lyase 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8879
neXtProt AC: NX_O95470

Human Synonyms: S1PL, SPL

Human Chr (Location): 10q21; chr10:70815948-70881189 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(24) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit premature death, skeletal and craniofacial defects, kidney defects, hematopoietic defects, decreased body weight and abnormal cell migration.
 
Phenotype Images(6)
Interactions
Sgpl1 interacts with 335 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process androgen metabolic process, apoptotic process, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function carboxy-lyase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (240)    Tissues (171)    Images (73)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 79
RNA in situ 161
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sgpl1    NEW 
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000031946 (Evidence)
Ensembl Gene Model ENSMUSG00000020097 (Evidence)
Entrez Gene 20397 (Evidence)
DFCI TC1700475, TC1573456
DoTS DT.101131964, DT.101738772, DT.99848970, DT.94286849
NIA Mouse Gene Index U031834
EC 4.1.2.27
Consensus CDS Project CCDS35914.1
International Mouse Phenotyping Consortium Status Sgpl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031946 VEGA Gene Model | MGI Sequence Detail 49062 C57BL/6J ±  kb
transcript OTTMUST00000079253 VEGA | MGI Sequence Detail 4070 Not Applicable 
polypeptide OTTMUSP00000042252 VEGA | MGI Sequence Detail 568 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(6) UniProt(8)
Polymorphisms
SNPs within 2kb(308 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002129 Pyridoxal phosphate-dependent decarboxylase
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
Protein Ontology PR:000014800 sphingosine-1-phosphate lyase 1
References
(Earliest) J:47955 Zhou J, et al., Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. Biochem Biophys Res Commun. 1998 Jan 26;242(3):502-7
(Latest) J:208373 Mezzar S, et al., RP-HPLC-fluorescence analysis of aliphatic aldehydes: application to aldehyde-generating enzymes HACL1 and SGPL1. J Lipid Res. 2014 Mar;55(3):573-82
All references(59)
Other
accession IDs
MGI:2143595

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory