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Bik
Gene Detail
Symbol

Name
ID
Bik
BCL2-interacting killer
MGI:1206591
Synonyms
Biklk, Blk, Nbk
Feature Type
protein coding gene
Genetic Map
Chromosome 15
39.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:83526862-83544635 bp, + strand
From Ensembl annotation of GRCm38

  17774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:924  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

HCOP human homology predictions: BIK
Protein SuperFamily: Bcl-2-interacting killer protein
Gene Tree: Bik

Human
homologs
BIK, BCL2-interacting killer (apoptosis-inducing)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 638
neXtProt AC: NX_Q13323

Human Synonyms: BIP1, BP4, NBK

Human Chr (Location): 22q13.31; chr22:43110748-43129712 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(20) Radiation induced(1) Targeted(3)
Genomic Mutations involving Bik (1)
 
Mice homozygous for a knock-out allele are viable and grossly normal with no detectable changes in hematopoiesis, lymphocyte susceptibility to various apoptotic stimuli, or endothelial cell apoptosis in hyaloid vessel regression.
 
Phenotype Images(2)
Interactions
Bik interacts with 58 markers (Mir98, Mir125a, Mir125b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process apoptotic mitochondrial changes, apoptotic process, ...
Component integral component of membrane, membrane, ...
Function BH domain binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (8)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 8
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(12) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000016758 (Evidence)
Entrez Gene 12124 (Evidence)
UniGene 267006
DFCI TC1588071, TC1594022
DoTS DT.91339300, DT.91428864, DT.482421
NIA Mouse Gene Index U016499
Consensus CDS Project CCDS27703.1
International Mouse Phenotyping Consortium Status Bik
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000016758 Ensembl Gene Model | MGI Sequence Detail 17774 C57BL/6J ±  kb
transcript ENSMUST00000016902 Ensembl | MGI Sequence Detail 943 Not Applicable 
polypeptide ENSMUSP00000016902 Ensembl | MGI Sequence Detail 150 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(12) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(189 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024579 Bcl-2-interacting killer
Protein Ontology PR:000004747 bcl-2-interacting killer
References
(Earliest) J:46845 Hegde R, et al., Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. J Biol Chem. 1998 Apr 3;273(14):7783-6
(Latest) J:204627 Lopez J, et al., Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik. Cell Death Differ. 2012 Sep;19(9):1459-69
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory