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Bik Gene Detail
Summary
  • Symbol
    Bik
  • Name
    BCL2-interacting killer
  • Synonyms
    Biklk, Blk, Nbk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1206591
    NCBI Gene: 12124
  • Gene Overview
    MyGene.info: BIK
Location & Maps
more
  • Sequence Map
    Chr15:83526862-83544635 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17774 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 39.40 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BIK, BCL2 interacting killer
  • Vertebrate Orthologs
    5
  • Human Ortholog
    BIK, BCL2 interacting killer
    Orthology source: HomoloGene
  • Synonyms
    BIP1, BP4, NBK
  • Links
    NCBI Gene ID: 638
    neXtProt AC: NX_Q13323

  • Chr Location
    22q13.31; chr22:43110748-43129712 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    22 phenotypes from multigenic genotypes
    27 phenotype references
  • All Mutations and Alleles
    26
  • Chemically induced (other)
    1
  • Gene trapped
    20
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Bik
Mice homozygous for a knock-out allele are viable and grossly normal with no detectable changes in hematopoiesis, lymphocyte susceptibility to various apoptotic stimuli, or endothelial cell apoptosis in hyaloid vessel regression.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000016758 Ensembl Gene Model | MGI Sequence Detail 17774 C57BL/6J ±  kb
transcript ENSMUST00000016902 Ensembl | MGI Sequence Detail 943 Not Applicable  
polypeptide ENSMUSP00000016902 Ensembl | MGI Sequence Detail 150 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    188 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000004747 bcl-2-interacting killer
  • InterPro Domains
    IPR024579 Bcl-2-interacting killer
Molecular
Reagents
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  • All nucleic 16
    Genomic 2
    cDNA 12
    Primer pair 1
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 6
    Phenotypes 27
  • Earliest
    J:46845 Hegde R, et al., Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. J Biol Chem. 1998 Apr 3;273(14):7783-6
  • Latest
    J:224352 Chen S, et al., Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik. Mol Cell Biol. 2014 Sep 15;34(18):3435-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory