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Bik
Gene Detail
Symbol

Name
ID
Bik
BCL2-interacting killer
MGI:1206591
Synonyms
Biklk, Blk, Nbk
Feature Type
protein coding gene
Genetic Map
Chromosome 15
39.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:83526862-83544635 bp, + strand
From NCBI annotation of GRCm38

  17774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:924  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: Bcl-2-interacting killer protein
Gene Tree: Bik

Human
homologs
Human Homolog BIK, BCL2-interacting killer (apoptosis-inducing)
NCBI Gene ID 638
neXtProt AC  NX_Q13323
Human Synonyms  BIP1, BP4, NBK
Human Chr (Location)  22q13.31; chr22:43110748-43129712 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(20) Radiation induced(1) Targeted(3)
Genomic Mutations involving Bik (1)
 
Mice homozygous for a knock-out allele are viable and grossly normal with no detectable changes in hematopoiesis, lymphocyte susceptibility to various apoptotic stimuli, or endothelial cell apoptosis in hyaloid vessel regression.
 
Interactions
Bik interacts with 58 markers (Mir98, Mir125a, Mir125b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process apoptotic mitochondrial changes, apoptotic process, ...
Component integral component of membrane, membrane, ...
Function BH domain binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (8)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 8
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(12) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000016758 (Evidence)
Entrez Gene12124 (Evidence)
UniGene267006
DFCITC1588071, TC1594022
DoTSDT.482421, DT.91339300, DT.91428864
NIA Mouse Gene IndexU016499
Consensus CDS ProjectCCDS27703.1
International Mouse Knockout Project StatusBik
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12124 NCBI Gene Model | MGI Sequence Detail 17774 C57BL/6J ±  kb
transcript NM_007546 RefSeq | MGI Sequence Detail 943 C57BL/6 
polypeptide O70337 UniProt | EBI | MGI Sequence Detail 150 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(12) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(189 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024579 Bcl-2-interacting killer
Protein Ontology PR:000004747 bcl-2-interacting killer
Graphical View of Protein Domain Structure
References
(Earliest) J:46845 Hegde R, et al., Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. J Biol Chem. 1998 Apr 3;273(14):7783-6
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory