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Prl4a1 Gene Detail
Summary
  • Symbol
    Prl4a1
  • Name
    prolactin family 4, subfamily a, member 1
  • Synonyms
    PLP-A, Prlpa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1206587
    NCBI Gene: 19110
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:28016223-28023546 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 12.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1206587
protein coding gene Chr13:28016212-28023559 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020407
protein coding gene Chr13:25741029-25748365 (+)
A/J MGP_AJ_G0020362
protein coding gene Chr13:25207746-25215082 (+)
AKR/J MGP_AKRJ_G0020339
protein coding gene Chr13:25631339-25638675 (+)
BALB/cJ MGP_BALBcJ_G0020357
protein coding gene Chr13:25235419-25242755 (+)
C3H/HeJ MGP_C3HHeJ_G0020160
protein coding gene Chr13:25712836-25720172 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020793
protein coding gene Chr13:26680260-26687704 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018384
protein coding gene Chr13:23613645-23619674 (+)
CAST/EiJ MGP_CASTEiJ_G0019677
protein coding gene Chr13:25321291-25328497 (+)
CBA/J MGP_CBAJ_G0020116
protein coding gene Chr13:27819080-27826376 (+)
DBA/2J MGP_DBA2J_G0020238
protein coding gene Chr13:24691953-24699289 (+)
FVB/NJ MGP_FVBNJ_G0020223
protein coding gene Chr13:24285842-24293178 (+)
LP/J MGP_LPJ_G0020315
protein coding gene Chr13:26060491-26067827 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020250
protein coding gene Chr13:28049737-28059616 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020834
protein coding gene Chr13:25367403-25374739 (+)
PWK/PhJ MGP_PWKPhJ_G0019432
protein coding gene Chr13:24815670-24823106 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019252
protein coding gene Chr13:24089862-24097201 (+)
WSB/EiJ MGP_WSBEiJ_G0019739
protein coding gene Chr13:25581292-25588633 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Female mice homozygous for a knock-out allele are unable to adapt to hypobaric hypoxia during gestation, resulting in pregnancy failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19110 NCBI Gene Model | MGI Sequence Detail 7324 C57BL/6J ±  kb
    transcript NM_011165 RefSeq | MGI Sequence Detail 865 C57BL/6  
    polypeptide O35256 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 1
      cDNA 56

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145153
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:179988 Hayakawa K, et al., Bridging sequence diversity and tissue-specific expression by DNA methylation in genes of the mouse prolactin superfamily. Mamm Genome. 2012 Jun;23(5-6):336-45

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory