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Pik3c2g
Gene Detail
Symbol

Name
ID
Pik3c2g
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
MGI:1203730
Feature Type
protein coding gene
Genetic Map
Chromosome 6
69.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:139587221-139969284 bp, + strand
From VEGA annotation of GRCm38

  382064 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3362  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PIK3C2G
Protein SuperFamily: C2 phosphatidylinositol 3-kinase
Gene Tree: Pik3c2g

Human
homologs
PIK3C2G, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5288
neXtProt AC: NX_O75747

Human Synonyms: PI3K-C2-gamma, PI3K-C2GAMMA

Human Chr (Location): 12p12; chr12:18242965-18699660 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Pik3c2g interacts with 239 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process adaptive immune response, cell chemotaxis, ...
Component cytoplasm, Golgi apparatus, ...
Function 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (107)    Tissues (105)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 107
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000048882 (Evidence)
Ensembl Gene Model ENSMUSG00000030228 (Evidence)
Entrez Gene 18705 (Evidence)
DFCI TC1588223, TC1592820, TC1596371, TC1597426, TC1614018, TC1615353, TC1645597
DoTS DT.101238396, DT.101308442, DT.101342830, DT.101707895, DT.101719628, DT.40136277, DT.40150377, DT.55159757, DT.91597707
NIA Mouse Gene Index U007511
EC 2.7.1.154
Consensus CDS Project CCDS80630.1
International Mouse Phenotyping Consortium Status Pik3c2g
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048882 VEGA Gene Model | MGI Sequence Detail 382064 C57BL/6J ±  kb
transcript OTTMUST00000124982 VEGA | MGI Sequence Detail 4407 Not Applicable 
polypeptide OTTMUSP00000067891 VEGA | MGI Sequence Detail 1021 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(4) UniProt(10)
Polymorphisms
RFLP(1) : SNPs within 2kb(5558 from dbSNP Build 137)    SNPs within 2kb including multiple locations(5560)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000008 C2 domain
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR002420 Phosphatidylinositol 3-kinase, C2 domain
InterPro IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro IPR015433 Phosphatidylinositol Kinase
InterPro IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro IPR001683 Phox homologous domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR029071 Ubiquitin-related domain
Protein Ontology PR:000012717 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
References
(Earliest) J:46628 Misawa H, et al., Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain. Biochem Biophys Res Commun. 1998 Mar 17;244(2):531-9
(Latest) J:221877 Mountford JK, et al., The class II PI 3-kinase, PI3KC2alpha, links platelet internal membrane structure to shear-dependent adhesive function. Nat Commun. 2015;6:6535
All references(31)
Other
accession IDs
MGI:2141760

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory