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Pik3c2g Gene Detail
Summary
  • Symbol
    Pik3c2g
  • Name
    phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203730
    NCBI Gene: 18705
  • Gene Overview
    MyGene.info: PIK3C2G
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:139614072-139969284 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 69.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4996 from dbSNP Build 142
  • Strain Annotations
    10
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203730
protein coding gene Chr6:139587221-139969284 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031444
protein coding gene Chr6:144264930-144639775 (+)
A/J MGP_AJ_G0031419
protein coding gene Chr6:138542734-138891995 (+)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0029017
protein coding gene Chr6:137492090-137824457 (+)
CAST/EiJ MGP_CASTEiJ_G0030516
protein coding gene Chr6:142328204-142697677 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0031256
protein coding gene Chr6:157765356-158142219 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031920
protein coding gene Chr6:142513461-142882674 (+)
PWK/PhJ MGP_PWKPhJ_G0030243
protein coding gene Chr6:135898445-136257988 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030067
protein coding gene Chr6:140759057-141116855 (+)
WSB/EiJ MGP_WSBEiJ_G0030609
protein coding gene Chr6:143170882-143531487 (+)



Homology
more
  • Human Ortholog
    PIK3C2G, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PIK3C2G, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PI3K-C2-gamma, PI3K-C2GAMMA
  • Links
    NCBI Gene ID: 5288
    neXtProt AC: NX_O75747
    UniProt: O75747

  • Chr Location
    12p12.3; chr12:18242946-18716861 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allelel exhibit reduced liver glucogen accumulation, hyperlipidemia, adiposity and insulin resistance with age or after consumption of a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18705 NCBI Gene Model | MGI Sequence Detail 355213 C57BL/6J ±  kb
    transcript NM_207683 RefSeq | MGI Sequence Detail 6280 C57BL/6  
    polypeptide O70167 UniProt | EBI | MGI Sequence Detail 1506 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141760
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 2
    • Earliest
      J:46628 Misawa H, et al., Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain. Biochem Biophys Res Commun. 1998 Mar 17;244(2):531-9
    • Latest
      J:245934 Xing Y, et al., Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1. Development. 2017 Oct 15;144(20):3798-3807

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory