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Pik3c2a Gene Detail
Summary
  • Symbol
    Pik3c2a
  • Name
    phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
  • Synonyms
    PI3KC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203729
    NCBI Gene: 18704
  • Gene Overview
    MyGene.info: PIK3C2A
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:116337265-116443449 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 61.62 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    528 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203729
protein coding gene Chr7:116337265-116443599 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032891
protein coding gene Chr7:120074970-120183739 (-)
A/J MGP_AJ_G0032874
protein coding gene Chr7:117058420-117163898 (-)
AKR/J MGP_AKRJ_G0032806
protein coding gene Chr7:120027722-120141515 (-)
BALB/cJ MGP_BALBcJ_G0032879
protein coding gene Chr7:116781531-116888674 (-)
C3H/HeJ MGP_C3HHeJ_G0032589
protein coding gene Chr7:119962279-120063860 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033385
protein coding gene Chr7:124884896-125002314 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030357
protein coding gene Chr7:118576115-118672770 (-)
CAST/EiJ MGP_CASTEiJ_G0031917
protein coding gene Chr7:111649295-111758188 (-)
CBA/J MGP_CBAJ_G0032562
protein coding gene Chr7:129026576-129137449 (-)
DBA/2J MGP_DBA2J_G0032714
protein coding gene Chr7:115111801-115213148 (-)
FVB/NJ MGP_FVBNJ_G0032667
protein coding gene Chr7:114962199-115073127 (-)
LP/J MGP_LPJ_G0032808
protein coding gene Chr7:121562492-121667108 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032699
protein coding gene Chr7:130639253-130761721 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033405
protein coding gene Chr7:119020109-119127296 (-)
PWK/PhJ MGP_PWKPhJ_G0031625
protein coding gene Chr7:107988385-108096079 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031472
protein coding gene Chr7:105751995-105861784 (-)
WSB/EiJ MGP_WSBEiJ_G0032030
protein coding gene Chr7:119897078-119999863 (-)



Homology
more
  • Human Ortholog
    PIK3C2A, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIK3C2A, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CPK, PI3-K-C2A, PI3K-C2alpha, PI3K-C2-alpha, PI3-K-C2(ALPHA)
  • Links
    NCBI Gene ID: 5286
    neXtProt AC: NX_O00443
    UniProt: O00443

  • Chr Location
    11p15.1; chr11:17086572-17207996 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele show chronic renal failure and a range of renal lesions that precede immune involvement. Mice heterozygous for a kinase-inactivating allele show defects in platelet formation, platelet membrane morphology and dynamics, and an enrichment of barbell proplatelets.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030660 Ensembl Gene Model | MGI Sequence Detail 106185 C57BL/6J ±  kb
    transcript ENSMUST00000170430 Ensembl | MGI Sequence Detail 8044 Not Applicable  
    polypeptide ENSMUSP00000126092 Ensembl | MGI Sequence Detail 1686 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • PDB
    • EC
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
      IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
      IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
      IPR002420 Phosphatidylinositol 3-kinase, C2 domain
      IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
      IPR015433 Phosphatidylinositol kinase
      IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
      IPR001683 Phox homologous domain
      IPR037705 PI3K-C2-alpha, catalytic domain
      IPR011009 Protein kinase-like domain superfamily
      IPR036871 PX domain superfamily
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
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    • All nucleic 111
      cDNA 110
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:33383 Molz L, et al., Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain. J Biol Chem. 1996 Jun 7;271(23):13892-9
    • Latest
      J:245586 Gulluni F, et al., Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2alpha Scaffolding Function. Cancer Cell. 2017 Oct 09;32(4):444-459.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory