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Pik3c2a
Gene Detail
Symbol

Name
ID
Pik3c2a
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
MGI:1203729
Synonyms
PI3KC2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
61.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:116337276-116443458 bp, - strand
From NCBI annotation of GRCm38

  106183 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20581  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: C2 phosphatidylinositol 3-kinase
Gene Tree: Pik3c2a

Human
homologs
Human Homolog PIK3C2A, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
NCBI Gene ID 5286
neXtProt AC  NX_O00443
Human Synonyms  CPK, PI3-K-C2A, PI3-K-C2(ALPHA)
Human Chr (Location)  11p15.5-p14; chr11:17086561-17207996 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit chronic renal failure and a range of renal lesions that precedes immune involvement.
 
Interactions
Pik3c2a interacts with 397 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process endocytosis, exocytosis, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000030660 (Evidence)
Entrez Gene18704 (Evidence)
DFCITC1582204, TC1591804, TC1628963, TC1632701
EC2.7.1.154
PDB2B3R
Consensus CDS ProjectCCDS52371.1
International Mouse Knockout Project StatusPik3c2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18704 NCBI Gene Model | MGI Sequence Detail 106183 C57BL/6J ±  kb
transcript NM_011083 RefSeq | MGI Sequence Detail 8042 C57BL/6 
polypeptide Q61194 UniProt | EBI | MGI Sequence Detail 1686 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(6) UniProt(9)
Polymorphisms
SNPs within 2kb(527 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR002420 Phosphatidylinositol 3-kinase C2 (PI3K C2) domain
InterPro IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro IPR015433 Phosphatidylinositol Kinase
InterPro IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro IPR001683 Phox homologous domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000012715 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Graphical View of Protein Domain Structure
References
(Earliest) J:33383 Molz L, et al., Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain. J Biol Chem. 1996 Jun 7;271(23):13892-9
(Latest) J:204751 Posor Y, et al., Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate. Nature. 2013 Jul 11;499(7457):233-7
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory