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Pik3c2a Gene Detail
Summary
  • Symbol
    Pik3c2a
  • Name
    phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
  • Synonyms
    PI3KC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203729
    NCBI Gene: 18704
  • Gene Overview
    MyGene.info: PIK3C2A
Location & Maps
more
  • Sequence Map
    Chr7:116337265-116443449 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      106185 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PIK3C2A, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIK3C2A, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CPK, PI3-K-C2A, PI3K-C2alpha, PI3K-C2-alpha, PI3-K-C2(ALPHA)
  • Links
    NCBI Gene ID: 5286
    neXtProt AC: NX_O00443

  • Chr Location
    11p15.5-p14; chr11:17086561-17207996 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit chronic renal failure and a range of renal lesions that precedes immune involvement.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058790 VEGA Gene Model | MGI Sequence Detail 106185 C57BL/6J ±  kb
transcript OTTMUST00000144373 VEGA | MGI Sequence Detail 5670 Not Applicable  
polypeptide OTTMUSP00000075257 VEGA | MGI Sequence Detail 1686 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    528 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000012715 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
  • PDB
  • EC
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR000008 C2 domain
    IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
    IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
    IPR002420 Phosphatidylinositol 3-kinase, C2 domain
    IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
    IPR015433 Phosphatidylinositol Kinase
    IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
    IPR001683 Phox homologous domain
    IPR011009 Protein kinase-like domain
    IPR029071 Ubiquitin-related domain
Molecular
Reagents
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  • All nucleic 110
    cDNA 109
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:33383 Molz L, et al., Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain. J Biol Chem. 1996 Jun 7;271(23):13892-9
  • Latest
    J:221877 Mountford JK, et al., The class II PI 3-kinase, PI3KC2alpha, links platelet internal membrane structure to shear-dependent adhesive function. Nat Commun. 2015;6:6535

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory