About   Help   FAQ
Pik3c2a
Gene Detail
Symbol

Name
ID
Pik3c2a
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
MGI:1203729
Synonyms
PI3KC2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
61.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:116337276-116443458 bp, - strand
From Ensembl annotation of GRCm38

  106183 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20581  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PIK3C2A
Protein SuperFamily: C2 phosphatidylinositol 3-kinase
Gene Tree: Pik3c2a

Human
homologs
PIK3C2A, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5286
neXtProt AC: NX_O00443

Human Synonyms: CPK, PI3-K-C2A, PI3-K-C2(ALPHA)

Human Chr (Location): 11p15.5-p14; chr11:17086561-17207996 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trap allele exhibit chronic renal failure and a range of renal lesions that precedes immune involvement.
 
Interactions
Pik3c2a interacts with 396 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(108)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PIK3C2A ; Xenbase pik3c2a ; ZFIN pik3c2a    NEW 
Molecular
reagents
All nucleic(110) cDNA(109) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000030660 (Evidence)
Entrez Gene 18704 (Evidence)
UniGene 3810
DFCI TC1628963, TC1582204, TC1632701, TC1591804
DoTS DT.101388097, DT.110988062, DT.485466, DT.91340150, DT.110988090
NIA Mouse Gene Index U029163
EC 2.7.1.154
PDB 2B3R
Consensus CDS Project CCDS52371.1
International Mouse Phenotyping Consortium Status Pik3c2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030660 Ensembl Gene Model | MGI Sequence Detail 106183 C57BL/6J ±  kb
transcript ENSMUST00000170430 Ensembl | MGI Sequence Detail 8042 Not Applicable 
polypeptide ENSMUSP00000126092 Ensembl | MGI Sequence Detail 1686 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(527 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR002420 Phosphatidylinositol 3-kinase C2 (PI3K C2) domain
InterPro IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro IPR015433 Phosphatidylinositol Kinase
InterPro IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro IPR001683 Phox homologous domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000012715 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
References
(Earliest) J:33383 Molz L, et al., Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain. J Biol Chem. 1996 Jun 7;271(23):13892-9
(Latest) J:221877 Mountford JK, et al., The class II PI 3-kinase, PI3KC2alpha, links platelet internal membrane structure to shear-dependent adhesive function. Nat Commun. 2015;6:6535
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory