Dtnb
Gene Detail

Symbol Name ID

Dtnb dystrobrevin, beta MGI:1203728

Feature Type

protein coding gene

Genetic Map

Chromosome 12

1.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr12:3572381-3781796 bp, + strand From VEGA annotation of GRCm38   209416 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74875  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: distrobrevin
Gene Tree: Dtnb

Human homologs

Human Homolog		DTNB, dystrobrevin, beta
NCBI Gene ID		1838
neXtProt AC		NX_O60941
Human Chr (Location)		2p24; chr2:25600067-25896516 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(101) : Targeted(3) Gene trapped(98)
 

Mice homozygous for a knock-out allele are viable and fertile and show no obvious histological or functional abnormalities in liver and kidney. Mice homozygous for a gene trapped allele are viable, fertile and overtly normal with no significant synaptic or behavioral defects.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Component	cytoplasm, synapse
Function	calcium ion binding, metal ion binding, ...

External Resources: FuncBase

Expression

cDNA source data(61)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(65) Genomic(1) cDNA(63) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037895 (Evidence)
Ensembl Gene Model	ENSMUSG00000071454 (Evidence)
Entrez Gene	13528 (Evidence)
UniGene	286202
DFCI	TC1579938, TC1586064, TC1593455, TC1664212
DoTS	DT.101709937, DT.40180684, DT.60100191, DT.97403287, DT.97403288, DT.97403289
NIA Mouse Gene Index	U013707
Consensus CDS Project	CCDS36396.2, CCDS49015.1
International Mouse Knockout Project Status	Dtnb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037895	VEGA Gene Model | MGI Sequence Detail	209416	C57BL/6J
transcript	OTTMUST00000097707	VEGA | MGI Sequence Detail	2355	Not Applicable
polypeptide	OTTMUSP00000054797	VEGA | MGI Sequence Detail	659	Not Applicable

All sequences(141) RefSeq(6) UniProt(19)

Polymorphisms

PCR(1) : SNPs(551 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017432	Distrobrevin
InterPro	IPR015153	EF-hand domain, type 1
InterPro	IPR015154	EF-hand domain, type 2
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR000433	Zinc finger, ZZ-type
Protein Ontology	PR:000006718	dystrobrevin beta

References

(Earliest) J:46808 Puca AA, et al., Identification and characterization of a novel member of the dystrobrevin gene family. FEBS Lett. 1998 Mar 20;425(1):7-13
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(45)