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Dtnb Gene Detail
Summary
  • Symbol
    Dtnb
  • Name
    dystrobrevin, beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203728
    NCBI Gene: 13528
  • Gene Overview
    MyGene.info: DTNB
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:3572381-3781796 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 1.88 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1212 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203728
protein coding gene Chr12:3572381-3783938 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019558
protein coding gene Chr12:387954-616377 (+)
A/J MGP_AJ_G0019525
protein coding gene Chr12:441473-654793 (+)
AKR/J MGP_AKRJ_G0019495
protein coding gene Chr12:569924-792517 (+)
BALB/cJ MGP_BALBcJ_G0019500
protein coding gene Chr12:468324-680976 (+)
C3H/HeJ MGP_C3HHeJ_G0019306
protein coding gene Chr12:350364-570362 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019950
protein coding gene Chr12:408469-628701 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017574
protein coding gene Chr12:382764-578363 (+)
CAST/EiJ MGP_CASTEiJ_G0018861
protein coding gene Chr12:409411-631548 (+)
CBA/J MGP_CBAJ_G0019277
protein coding gene Chr12:626497-869170 (+)
DBA/2J MGP_DBA2J_G0019390
protein coding gene Chr12:393427-599181 (+)
FVB/NJ MGP_FVBNJ_G0019381
protein coding gene Chr12:414255-621504 (+)
LP/J MGP_LPJ_G0019461
protein coding gene Chr12:418894-642394 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019414
protein coding gene Chr12:453373-688807 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019988
protein coding gene Chr12:354371-571248 (+)
PWK/PhJ MGP_PWKPhJ_G0018627
protein coding gene Chr12:403500-607383 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018418
protein coding gene Chr12:428322-658925 (+)
WSB/EiJ MGP_WSBEiJ_G0018913
protein coding gene Chr12:382819-605378 (+)



Homology
more
  • Human Ortholog
    DTNB, dystrobrevin beta
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DTNB, dystrobrevin beta
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 1838
    neXtProt AC: NX_O60941
    UniProt: O60941

  • Chr Location
    2p23.3; chr2:25377220-25673647 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    11 phenotype references
Mice homozygous for a knock-out allele are viable and fertile and show no obvious histological or functional abnormalities in liver and kidney. Mice homozygous for a gene trapped allele are viable, fertile and overtly normal with no significant synaptic or behavioral defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071454 Ensembl Gene Model | MGI Sequence Detail 209416 C57BL/6J ±  kb
transcript ENSMUST00000164578 Ensembl | MGI Sequence Detail 2355 Not Applicable  
polypeptide ENSMUSP00000126194 Ensembl | MGI Sequence Detail 659 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 65
    Genomic 1
    cDNA 63
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 44
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:46808 Puca AA, et al., Identification and characterization of a novel member of the dystrobrevin gene family. FEBS Lett. 1998 Mar 20;425(1):7-13
  • Latest
    J:201389 Fratini F, et al., Phosphorylation on threonine 11 of beta-dystrobrevin alters its interaction with kinesin heavy chain. FEBS J. 2012 Nov;279(22):4131-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory