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Dtnb Gene Detail
Summary
  • Symbol
    Dtnb
  • Name
    dystrobrevin, beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203728
    NCBI Gene: 13528
  • Gene Overview
    MyGene.info: DTNB
Location & Maps
more
  • Sequence Map
    Chr12:3572381-3781796 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      209416 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 1.88 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    DTNB, dystrobrevin beta
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DTNB, dystrobrevin beta
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 1838
    neXtProt AC: NX_O60941

  • Chr Location
    2p24; chr2:25377198-25673647 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    11 phenotype references
Mice homozygous for a knock-out allele are viable and fertile and show no obvious histological or functional abnormalities in liver and kidney. Mice homozygous for a gene trapped allele are viable, fertile and overtly normal with no significant synaptic or behavioral defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037895 VEGA Gene Model | MGI Sequence Detail 209416 C57BL/6J ±  kb
transcript OTTMUST00000097707 VEGA | MGI Sequence Detail 2355 Not Applicable  
polypeptide OTTMUSP00000054797 VEGA | MGI Sequence Detail 659 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1212 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 64
    Genomic 1
    cDNA 62
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 42
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:46808 Puca AA, et al., Identification and characterization of a novel member of the dystrobrevin gene family. FEBS Lett. 1998 Mar 20;425(1):7-13
  • Latest
    J:201389 Fratini F, et al., Phosphorylation on threonine 11 of beta-dystrobrevin alters its interaction with kinesin heavy chain. FEBS J. 2012 Nov;279(22):4131-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory