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Magi1 Gene Detail
Summary
  • Symbol
    Magi1
  • Name
    membrane associated guanylate kinase, WW and PDZ domain containing 1
  • Synonyms
    AIP3, Baiap1, BAP1, Gukmi1, WWP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203522
    NCBI Gene: 14924
  • Gene Overview
    MyGene.info: MAGI1
Location & Maps
more
  • Sequence Map
    Chr6:93675455-94283917 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      608463 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 42.70 cM, cytoband D3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAGI1, membrane associated guanylate kinase, WW and PDZ domain containing 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAGI1, membrane associated guanylate kinase, WW and PDZ domain containing 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AIP3, AIP-3, BAIAP1, BAP1, BAP-1, MAGI-1, Magi1d, TNRC19, WWP3
  • Links
    NCBI Gene ID: 9223
    neXtProt AC: NX_Q96QZ7

  • Chr Location
    3p14.1; chr3:65330764-66038836 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    164
  • Gene trapped
    161
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Magi1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057755 VEGA Gene Model | MGI Sequence Detail 608463 C57BL/6J ±  kb
transcript OTTMUST00000141846 VEGA | MGI Sequence Detail 7929 Not Applicable  
polypeptide OTTMUSP00000074058 VEGA | MGI Sequence Detail 1280 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6801 from dbSNP Build 142
Protein
Information
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  • UniProt
    17 Sequences
  • Protein Ontology
    PR:000010083 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
  • PDB
  • InterPro Domains
    IPR020590 Guanylate kinase, conserved site
    IPR008144 Guanylate kinase-like domain
    IPR008145 Guanylate kinase/L-type calcium channel beta subunit
    IPR030033 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
    IPR001478 PDZ domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001202 WW domain
Molecular
Reagents
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  • All nucleic 105
    Genomic 1
    cDNA 104

    Microarray probesets 6
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:44633 Dobrosotskaya I, et al., MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains. J Biol Chem. 1997 Dec 12;272(50):31589-97
  • Latest
    J:207976 Li Q, et al., The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory