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Map3k19 Gene Detail
Summary
  • Symbol
    Map3k19
  • Name
    mitogen-activated protein kinase kinase kinase 19
  • Synonyms
    Ysk4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203481
    NCBI Gene: 22625
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:127815253-127855031 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 55.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    270 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203481
protein coding gene Chr1:127813481-127855613 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016423
protein coding gene Chr1:131036571-131073716 (-)
A/J MGP_AJ_G0016406
protein coding gene Chr1:126153590-126192274 (-)
AKR/J MGP_AKRJ_G0016371
protein coding gene Chr1:129865997-129903097 (-)
BALB/cJ MGP_BALBcJ_G0016366
protein coding gene Chr1:126532009-126572183 (-)
C3H/HeJ MGP_C3HHeJ_G0016192
protein coding gene Chr1:130050200-130089753 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016827
protein coding gene Chr1:135963019-136002916 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014540
protein coding gene Chr1:119513340-119554321 (-)
CAST/EiJ MGP_CASTEiJ_G0015773
protein coding gene Chr1:129015961-129057228 (-)
CBA/J MGP_CBAJ_G0016165
protein coding gene Chr1:140547329-140593625 (-)
DBA/2J MGP_DBA2J_G0016271
protein coding gene Chr1:125190418-125232149 (-)
FVB/NJ MGP_FVBNJ_G0016270
protein coding gene Chr1:123908620-123944087 (-)
LP/J MGP_LPJ_G0016342
protein coding gene Chr1:132388279-132425105 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016295
protein coding gene Chr1:146412359-146451856 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016863
protein coding gene Chr1:129657745-129697440 (-)
PWK/PhJ MGP_PWKPhJ_G0015559
protein coding gene Chr1:124163016-124206023 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015347
protein coding gene Chr1:128609385-128648677 (-)
WSB/EiJ MGP_WSBEiJ_G0015835
protein coding gene Chr1:129607966-129652524 (-)



Homology
more
  • Human Ortholog
    MAP3K19, mitogen-activated protein kinase kinase kinase 19
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAP3K19, mitogen-activated protein kinase kinase kinase 19
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RCK, YSK4
  • Links
    NCBI Gene ID: 80122
    neXtProt AC: NX_Q56UN5
    UniProt: Q56UN5

  • Chr Location
    2q21.3; chr2:134963875-135047468 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051590 Ensembl Gene Model | MGI Sequence Detail 39779 C57BL/6J ±  kb
transcript ENSMUST00000208183 Ensembl | MGI Sequence Detail 4865 Not Applicable  
polypeptide ENSMUSP00000146463 Ensembl | MGI Sequence Detail 1515 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • EC
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
    IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Molecular
Reagents
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  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 20
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory