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Csrp2
Gene Detail
Symbol

Name
ID
Csrp2
cysteine and glycine-rich protein 2
MGI:1202907
Synonyms
Crp2, SmLim
Feature Type
protein coding gene
Genetic Map
Chromosome 10
57.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:110920176-110939514 bp, + strand
From NCBI annotation of GRCm38

  19339 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:111061  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CSRP2
Gene Tree: Csrp2

Human
homologs
CSRP2, cysteine and glycine-rich protein 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1466
neXtProt AC: NX_Q16527

Human Synonyms: CRP2, LMO5, SmLIM

Human Chr (Location): 12q21.1; chr12:76858715-76879046 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(246) : Gene trapped(242) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null allele display increased neointima formation following arterial injury and increased migration of vascular smooth muscle cells in response to PDGF-BB. Mice homozygous for a second null allele display abnormal inflammatory pain responses.
 
Interactions
Csrp2 interacts with 51 markers (Mir10b, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cell differentiation, multicellular organismal development
Component focal adhesion, nucleus
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (161)    Tissues (79)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 143
Northern blot 10
RT-PCR 8
cDNA source data(85)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase csrp2    NEW 
Molecular
reagents
All nucleic(88) Genomic(1) cDNA(86) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000020186 (Evidence)
Entrez Gene 13008 (Evidence)
UniGene 2020
DFCI TC1576681
DoTS DT.494812, DT.94403574
NIA Mouse Gene Index U011996
Consensus CDS Project CCDS24165.1
International Mouse Phenotyping Consortium Status Csrp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13008 NCBI Gene Model | MGI Sequence Detail 19339 C57BL/6J ±  kb
transcript NM_007792 RefSeq | MGI Sequence Detail 889 C57BL/6 
polypeptide P97314 UniProt | EBI | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(359 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000005959 cysteine and glycine-rich protein 2
Graphical View of Protein Domain Structure
References
(Earliest) J:32734 Jain MK, et al., Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells. J Biol Chem. 1996 Apr 26;271(17):10194-9
(Latest) J:219552 Chen CH, et al., Cysteine-rich protein 2 alters p130Cas localization and inhibits vascular smooth muscle cell migration. Cardiovasc Res. 2013 Dec 1;100(3):461-71
All references(53)
Other
accession IDs
MGI:2143863

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory